• Istituto di Biologia e Patologia Molecolari

Publications 2024

A comprehensive analysis of SARS-CoV-2 missense mutations indicates that all possible amino acid replacements in the viral proteins occurred within the first two-and-a-half years of the pandemic.
Balasco N, Damaggio G, Esposito L, Colonna V, Vitagliano L.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2024;266(Pt 1). doi: 10.1016/j.ijbiomac.2024.131054.

A Comprehensive Analysis of the Structural Recognition between KCTD Proteins and Cullin 3.
Balasco N, Esposito L, Smaldone G, Salvatore M, Vitagliano L.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(3). doi: 10.3390/ijms25031881.

A tripartite circRNA/mRNA/miRNA interaction regulates glutamatergic signaling in the mouse brain.
Silenzi V, D'Ambra E, Santini T, D'Uva S, Setti A, Salvi N, Nicoletti C, Scarfò R, Cordella F, Mongiardi B, Cavezza D, Liessi N, Ferrucci L, Ragozzino D, Armirotti A, Di Angelantonio S, De Leonibus E, Bozzoni I, Morlando M.
CELL REPORTS. 2024;43(10). doi: 10.1016/j.celrep.2024.114766.

Alcohol Consumption and Breast and Ovarian Cancer Development: Molecular Pathways and Mechanisms.
Fanfarillo F, Caronti B, Lucarelli M, Francati S, Tarani L, Ceccanti M, Piccioni MG, Verdone L, Caserta M, Venditti S, Ferraguti G, Fiore M.
CURRENT ISSUES IN MOLECULAR BIOLOGY. 2024;46(12). doi: 10.3390/cimb46120866.

An antisense-long-noncoding-RNA modulates p75NTR expression levels during neuronal polarization.
De Paolis V, Paolillo N, Siri T, Grosso A, Lorello V, Spina C, Caporali G, La Regina F, Vignoli B, Giorgi C.
ISCIENCE. 2024;28(1). doi: 10.1016/j.isci.2024.111566.

An inherited TBX3 alteration in a prenatal case of ulnar-mammary syndrome: Clinical assessment and functional characterization in Drosophila melanogaster.
Bottillo I, D'Alessandro A, Ciccone Maria P, Cestra G, Di Giacomo G, Silvestri E, Castori M, Brancati F, Lenzi A, Paiardini A, Majore S, Cenci G, Grammatico P.
JOURNAL OF CELLULAR PHYSIOLOGY. 2024;(12). doi: 10.1002/jcp.31440.

Antibiotics treatment promotes vasculogenesis in the brain of glioma-bearing mice.
Rosito M, Maqbool J, Reccagni A, Giampaoli O, Sciubba F, Antonangeli F, Scavizzi F, Raspa M, Cordella F, Tondo L, Di Angelantonio S, Trettel F, Miccheli A, D'Alessandro G, Limatola C.
CELL DEATH & DISEASE. 2024;15(3). doi: 10.1038/s41419-024-06578-w.

AurkA/TPX2 co-overexpression in nontransformed cells promotes genome instability through induction of chromosome mis-segregation and attenuation of the p53 signalling pathway.
Naso FD, Polverino F, Cilluffo D, Latini L, Stagni V, Asteriti IA, Rosa A, Soddu S, Guarguaglini G.
BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE. 2024;1870(4). doi: 10.1016/j.bbadis.2024.167116.

Binding of steroid substrates reveals the key to the productive transition of the cytochrome P450 OleP.
Costanzo A, Fata F, Freda I, De Sciscio ML, Gugole E, Bulfaro G, Di Renzo M, Barbizzi L, Exertier C, Parisi G, D'Abramo M, Vallone B, Savino C, Montemiglio LC.
STRUCTURE. 2024;32(9). doi: 10.1016/j.str.2024.06.005.

Capturing the fusion of two ancestries and kinship structures in Merovingian Flanders.
Sasso S, Saag L, Spros R, Beneker O, Molinaro L, Biagini SA, Lehouck A, De Vijver KV, Hui R, D'Atanasio E, Kushniarevich A, Kabral H, Metspalu E, Guellil M, Ali MQA, Geypen J, Hoebreckx M, Berk B, De Winter N, Driesen P, Pijpelink A, Van Damme P, Scheib CL, Deschepper E, Deckers P, Snoeck C, Dewilde M, Ervynck A, Tambets K, Larmuseau MHD, Kivisild T.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(27). doi: 10.1073/pnas.2406734121.

Catalytic specificity and crystal structure of cystathionine γ-lyase from Pseudomonas aeruginosa.
Pedretti M, Fernández-Rodríguez C, Conter C, Oyenarte I, Favretto F, Di Matteo A, Dominici P, Petrosino M, Martinez-Chantar ML, Majtan T, Astegno A, Martínez-Cruz LA.
SCIENTIFIC REPORTS. 2024;14(1). doi: 10.1038/s41598-024-57625-7.

CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma.
Cuollo L, Di Cristofano S, Sandomenico A, Iaccarino E, Oliver A, Zingoni A, Cippitelli M, Fionda C, Petillo S, Kosta A, Tassinari V, Teresa Petrucci M, Fazio F, Ruvo M, Santoni A, Raimondo D, Soriani A.
ISCIENCE. 2024;27(5). doi: 10.1016/j.isci.2024.109814.

Coffee Bioactive N-Methylpyridinium: Unveiling Its Antilipogenic Effects by Targeting De Novo Lipogenesis in Human Hepatocytes.
Giannotti L, Stanca E, Di Chiara Stanca B, Spedicato F, Massaro M, Quarta S, Del Rio D, Mena P, Siculella L, Damiano F.
MOLECULAR NUTRITION & FOOD RESEARCH. 2024;68(21). doi: 10.1002/mnfr.202400338.

Conformational and dynamic properties of the KH1 domain of FMRP and its fragile X syndrome linked G266E variant.
Catalano F, Santorelli D, Astegno A, Favretto F, D'Abramo M, Del Giudice A, De Sciscio ML, Troilo F, Giardina G, Di Matteo A, Travaglini-Allocatelli C.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. 2024;1872(4). doi: 10.1016/j.bbapap.2024.141019.

Contribution of AurkA/TPX2 Overexpression to Chromosomal Imbalances and Cancer.
Polverino F, Mastrangelo A, Guarguaglini G.
CELLS. 2024;13(16). doi: 10.3390/cells13161397.

Core-extended Naphthalene Diimide dyads as light-up probes with targeted cytotoxicity toward tumor cells.
Manet IG, Doria F, Pirota V, Freccero M, Salvati E, Manoli F, Risoldi C, Zizza P, Biroccio A, Rizzo A.
ChemRxiv. 2024. doi: 10.26434/chemrxiv-2024-n178z.

CRF transcription factors in the trade-off between abiotic stress response and plant developmental processes.
Gentile D, Serino G, Frugis G.
FRONTIERS IN GENETICS. 2024;15. doi: 10.3389/fgene.2024.1377204.

Cul-4 inhibition rescues spastin levels and reduces defects in hereditary spastic paraplegia models.
Sardina F, Carsetti C, Giorgini L, Fattorini G, Cestra G, Rinaldo C.
Brain. 2024 Oct 3;147(10):3534-3546. doi: 10.1093/brain/awae095.

Cumulative dose from recurrent CT scans: exploring the DNA Damage Response in human non-transformed cells.
Valente D, Gentileschi MP, Valenti A, Burgio M, Soddu S, Bruzzaniti V, Guerrisi A, Verdina A.
Int J Mol Sci. 2024 Jun 27;25(13):7064. doi: 10.3390/ijms25137064.

Cyanide Insensitive Oxidase Confers Hydrogen Sulfide and Nitric Oxide Tolerance to Pseudomonas aeruginosa Aerobic Respiration.
Nastasi MR, Caruso L, Giordano F, Mellini M, Rampioni G, Giuffre' A, Forte E.
ANTIOXIDANTS. 2024;13(3). doi: 10.3390/antiox13030383.

Development of Loop-Mediated Isothermal Amplification (LAMP) Assays for the Rapid Detection of Toxigenic Aspergillus flavus and A. carbonarius in Nuts.
Mellikeche W, Ricelli A, Casini G, Gallo M, Baser N, Colelli G, Maria D'Onghia A.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(7). doi: 10.3390/ijms25073809.

Discovering Dually Active Anti-cancer Compounds with a Hybrid AI-structure-based Approach.
Roggia M, Natale B, Amendola G, Grasso N, Di Maro S, Taliani S, Castellano S, Reina SCR, Salvati E, Amato J, Cosconati S.
JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2024;64(21):8299-8309. doi: 10.1021/acs.jcim.4c01132.

Effect of Cholesterol-Lowering Variants in ANGPTL3 and APOB Genes on Liver Disease.
Di Costanzo A, Pirona I, Buonaiuto S, D'Erasmo L, Bini S, Tramontano D, Covino S, Maiorca C, Minicocci I, Sponziello M, Baratta F, Commodari D, Colonna V, Via A, Arca M.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2024;84(18):1767-1770. doi: 10.1016/j.jacc.2024.08.013.

Endothelin-1 receptor blockade impairs invasion patterns in engineered 3D high-grade serous ovarian cancer tumoroids.
Pape J, Cheema U, Tocci P, Sestito R, Masi I, Loizidou M, Bagnato A, Rosano' L.
CLINICAL SCIENCE. 2024;(22). doi: 10.1042/cs20240371.

Enhanced Growth and Contrasting Effects on Arsenic Phytoextraction in Pteris vittata through Rhizosphere Bacterial Inoculations.
Antenozio ML, Giannelli G, Fragni R, Baragaño D, Brunetti P, Visioli G, Cardarelli M.
Plants (Basel). 2024 Jul 24;13(15):2030. doi: 10.3390/plants13152030.

ESI MS Studies of T. Brucei Trypanothione Reductase and its Reactions With Selected Metal Compounds.
Zineddu S, Geri A, Ilari A, Colotti G, Exertier C, Fiorillo A, Antonelli L, Messori L.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. 2024;27(36). doi: 10.1002/ejic.202400499.

Evaluating the potential of non-immunosuppressive cyclosporin analogs for targeting Toxoplasma gondii cyclophilin: Insights from structural studies.
Favretto F, Jiménez-Faraco E, Catucci G, Di Matteo A, Travaglini-Allocatelli C, Sadeghi SJ, Dominici P, Hermoso JA, Astegno A.
PROTEIN SCIENCE. 2024;33(10). doi: 10.1002/pro.5157.

Evidence of Gd substitution for Y in YBCO films with Gd excess.
Reale P, Pinto V, Cayado P, Celentano G, Armenio AA, Rufoloni A, Santoni A, D'Acapito F.
JOURNAL OF ALLOYS AND COMPOUNDS. 2024;983. doi: 10.1016/j.jallcom.2024.173921.

Exploring the conformational space of the mobile flap in Sporosarcina pasteurii urease by cryo-electron microscopy.
Mazzei L, Tria G, Ciurli S, Cianci M.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2024;283(Pt 3). doi: 10.1016/j.ijbiomac.2024.137904.

EXTOD-Immune: a randomised controlled trial to investigate whether a remotely monitored, home-based exercise intervention can reduce disease activity in people with type 1 diabetes.
Quickfall M, Cocks M, Long HM, Di Rosa F, Andrews R, Narendran P, Hesketh K, Wadley AJ.
BMJ OPEN SPORT & EXERCISE MEDICINE. 2024;10(3). doi: 10.1136/bmjsem-2024-002144.

First report of Aspergillus species in green pistachio of Bronte.
Mellikeche W, Casini G, Gallo M, D'Onghia AM, Colelli G, Ricelli A.
PHYTOPATHOLOGIA MEDITERRANEA. 2024;63(1):103-110. doi: 10.36253/phyto-14949.

Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis.
Exertier C, Salerno A, Antonelli L, Fiorillo A, Ocello R, Seghetti F, Caciolla J, Uliassi E, Masetti M, Fiorentino E, Orsini S, Di Muccio T, Ilari A, Bolognesi ML.
JOURNAL OF MEDICINAL CHEMISTRY. 2024;67(1):402-419. doi: 10.1021/acs.jmedchem.3c01439.

Genetic history of Cambridgeshire before and after the Black Death.
Hui R, Scheib CL, D'Atanasio E, Inskip SA, Cessford C, Biagini SA, Wohns AW, Ali MQA, Griffith SJ, Solnik A, Niinemae H, Ge XJ, Rose AK, Beneker O, O'Connell TC, Robb JE, Kivisild T.
SCIENCE ADVANCES. 2024;10(3). doi: 10.1126/sciadv.adi5903.

HD-Zip II transcription factors control distal stem cell fate in Arabidopsis roots by linking auxin signaling to the FEZ/SOMBRERO pathway.
Possenti M, Sessa G, Alfè A, Turchi L, Ruzza V, Sassi M, Morelli G, Ruberti I.
DEVELOPMENT (CAMB.). 2024;(8). doi: 10.1242/dev.202586.

HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling.
Terri M, Sandoval P, Bontempi G, Montaldo C, Tomero-Sanz H, de Turris V, Trionfetti F, Pascual-Antón L, Clares-Pedrero I, Battistelli C, Valente S, Zwergel C, Mai A, Rosanò L, del Pozo MÁ, Sánchez-Álvarez M, Cabañas C, Tripodi M, López-Cabrera M, Strippoli R.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2024;43(1). doi: 10.1186/s13046-023-02930-8.

HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscape.
Zamperla MG, Illi B, Barbi V, Cencioni C, Santoni D, Gagliardi S, Garofalo M, Zingale GA, Pandino I, Sbardella D, Cipolla L, Sabbioneda S, Farsetti A, Ripamonti C, Fossati G, Steinkuhler C, Gaetano C, Atlante S.
CLINICAL EPIGENETICS. 2024;16(1). doi: 10.1186/s13148-024-01725-8.

Hydrogen sulfide production does not affect antibiotic resistance in Pseudomonas aeruginosa.
Caruso L, Mellini M, Catalano Gonzaga O, Astegno A, Forte E, Di Matteo A, Giuffre' A, Visca P, Imperi F, Leoni L, Rampioni G.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2024;68(4). doi: 10.1128/aac.00075-24.

Identification of the pyridoxal 5?-phosphate allosteric site in human pyridox(am)ine 5?-phosphate oxidase.
Barile A, Graziani C, Antonelli L, Parroni A, Fiorillo A, Luigi di Salvo M, Ilari A, Giorgi A, Rosignoli S, Paiardini A, Contestabile R, Tramonti A.
PROTEIN SCIENCE (ONLINE). 2024;33(2). doi: 10.1002/pro.4900.

Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis.
Sozzi S, Manni I, Ercolani C, Diodoro MG, Bartolazzi A, Spallotta F, Piaggio G, Monteonofrio L, Soddu S, Rinaldo C, Valente D.
J Exp Clin Cancer Res. 2024 Sep 28;43(1):265. doi: 10.1186/s13046-024-03189-3.

Inflammation promotes stomach epithelial defense by stimulating the secretion of antimicrobial peptides in the mucus.
Vllahu M, Voli A, Licursi V, Zagami C, D'Amore A, Traulsen J, Woelffling S, Schmid M, Crickley R, Lisle R, Link A, Tosco A, Meyer TF, Boccellato F.
Gut Microbes. 2024 Jan-Dec;16(1):2390680. doi: 10.1080/19490976.2024.2390680.

Interaction between miR-142-3p and BDNF Val/Met Polymorphism Regulates Multiple Sclerosis Severity.
Dolcetti E, Musella A, Balletta S, Gilio L, Bruno A, Stampanoni Bassi M, Lauritano G, Buttari F, Fresegna D, Tartacca A, Mariani F, Palmerio F, Rovella V, Ferese R, Gambardella S, Giardina E, Finardi A, Furlan R, Mandolesi G, Centonze D, De Vito F.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(10). doi: 10.3390/ijms25105253.

Interleukin-10 contrasts inflammatory synaptopathy and central neurodegenerative damage in multiple sclerosis.
Gilio L, Fresegna D, Stampanoni Bassi M, Musella A, De Vito F, Balletta S, Sanna K, Caioli S, Pavone L, Galifi G, Simonelli I, Guadalupi L, Vanni V, Buttari F, Dolcetti E, Bruno A, Azzolini F, Borrelli A, Fantozzi R, Finardi A, Furlan R, Centonze D, Mandolesi G.
FRONTIERS IN MOLECULAR NEUROSCIENCE. 2024;17. doi: 10.3389/fnmol.2024.1430080.

Interleukin-9 protects from microglia- and TNF-mediated synaptotoxicity in experimental multiple sclerosis.
Guadalupi L, Vanni V, Balletta S, Caioli S, De Vito F, Fresegna D, Sanna K, Nencini M, Donninelli G, Volpe E, Mariani F, Battistini L, Stampanoni Bassi M, Gilio L, Bruno A, Dolcetti E, Buttari F, Mandolesi G, Centonze D, Musella A.
JOURNAL OF NEUROINFLAMMATION. 2024;21(1). doi: 10.1186/s12974-024-03120-9.

Iron capture through CD71 drives perinatal and tumor-associated Treg expansion.
Pacella I, Pinzon Grimaldos A, Rossi A, Tucci G, Zagaglioni M, Potenza E, Pinna V, Rotella I, Cammarata I, Cancila V, Belmonte B, Tripodo C, Pietropaolo G, Di Censo C, Sciumè G, Licursi V, Peruzzi G, Antonucci Y, Campello S, Guerrieri F, Iebba V, Prota R, Di Chiara M, Terrin G, De Peppo V, Grazi GL, Barnaba V, Piconese S.
JCI INSIGHT. 2024;9(15). doi: 10.1172/jci.insight.167967.

Low Genetic Impact of the Roman Occupation of Britain in Rural Communities.
Scheib CL, Hui R, Rose AK, D'Atanasio E, Inskip SA, Dittmar J, Cessford C, Griffith SJ, Solnik A, Wiseman R, Neil B, Biers T, Harknett SJ, Sasso S, Biagini SA, Runfeldt G, Duhig C, Evans C, Metspalu M, Millett MJ, Oconnell TC, Robb JE, Kivisild T.
MOLECULAR BIOLOGY AND EVOLUTION. 2024;41(9). doi: 10.1093/molbev/msae168.

M2 Muscarinic Receptor Stimulation Induces Autophagy in Human Glioblastoma Cancer Stem Cells via mTOR Complex-1 Inhibition.
Guerriero C, Manfredelli M, Matera C, Iuzzolino A, Conti L, Dallanoce C, De Amici M, Trisciuoglio D, Tata AM.
CANCERS. 2024;16(1). doi: 10.3390/cancers16010025.

M2 muscarinic receptors negatively modulate cell migration in human glioblastoma cells.
Guerriero C, Fanfarillo R, Mancini P, Sterbini V, Guarguaglini G, Sforna L, Michelucci A, Catacuzzeno L, Tata AM.
NEUROCHEMISTRY INTERNATIONAL. 2024;174. doi: 10.1016/j.neuint.2023.105673.

miR-125 in breast cancer etiopathogenesis: an emerging role as a biomarker in differential diagnosis, regenerative medicine, and the challenges of personalized medicine.
Piergentili R, Marinelli E, Cucinella G, Lopez A, Napoletano G, Gullo G, Zaami S.
Noncoding RNA. 2024 Feb 21;10(2):16. doi: 10.3390/ncrna10020016.

Modulating the skin mycobiome-bacteriome and treating seborrheic dermatitis with a probiotic-enriched oily suspension.
Truglio M, Sivori F, Cavallo I, Abril E, Licursi V, Fabrizio G, Cardinali G, Pignatti M, Toma L, Valensise F, Cristaudo A, Pimpinelli F, Di Domenico EG.
SCIENTIFIC REPORTS. 2024;14(1). doi: 10.1038/s41598-024-53016-0.

Multifunctional FFP2 Face Mask for White Light Disinfection and Pathogens Detection using Hybrid Nanostructures and Optical Metasurfaces.
Zaccagnini F, De Biase D, Bovieri F, Perotto G, Quagliarini E, Bavasso I, Mangino G, Iuliano M, Calogero A, Romeo G, Singh DP, Pierini F, Caracciolo G, Petronella F, De Sio L.
SMALL. 2024;20(38). doi: 10.1002/smll.202400531.

Neutrophil-activating secretome characterizes palbociclib-induced senescence of breast cancer cells.
Favaretto G, Rossi MN, Cuollo L, Laffranchi M, Cervelli M, Soriani A, Sozzani S, Santoni A, Antonangeli F.
Cancer Immunol Immunother. 2024 May 2;73(6):113. doi: 10.1007/s00262-024-03695-5.

New evidence of the timing of arsenic accumulation and expression of arsenic-response genes in field-grown Pteris vittata plants under different arsenic concentrations.
Antenozio ML, Capobianco G, Allevato E, Marabottini R, Stazi SR, Bonifazi G, Serranti S, Brunetti P, Cardarelli M.
Environ Pollut. 2024 Aug 31;361:124873. doi: 10.1016/j.envpol.2024.124873.

Non-coding RNAs of mitochondrial origin: roles in cell division and implications in cancer.
Piergentili R, Sechi S.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;(13). doi: 10.3390/ijms25137498.

Nose-to-brain selective drug delivery to glioma via ferritin-based nanovectors reduces tumor growth and improves survival rate.
Marrocco F, Falvo E, Mosca L, Tisci G, Arcovito A, Reccagni A, Limatola C, Bernardini R, Ceci P, D'Alessandro G, Colotti G.
Cell Death Dis. 2024 Apr 13;15(4):262. doi: 10.1038/s41419-024-06653-2.

Novel insights into the role of Discoidin domain receptor 2 (DDR2) in cancer progression: a new avenue of therapeutic intervention.
Trono P, Ottavi F, Rosano' L.
Matrix Biol. 2024 Jan;125:31-39. doi: 10.1016/j.matbio.2023.12.003.

One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse.
Malatesta M, Fornasier E, Di Salvo ML, Tramonti A, Zangelmi E, Peracchi A, Secchi A, Polverini E, Giachin G, Battistutta R, Contestabile R, Percudani R.
NATURE COMMUNICATIONS. 2024;15(1). doi: 10.1038/s41467-024-47466-3.

Oxidative Stress in Transthyretin-Mediated Amyloidosis: An Exploratory Study.
Fiore M, Cambieri C, Libonati L, Moret F, D'Andrea E, Di Certo MG, Passananti C, Gabanella F, Corbi N, Garibaldi M, Chimenti C, Alfarano M, Ferraguti G, Francati S, Inghilleri M, Ceccanti M.
ANTIOXIDANTS. 2024;13(8). doi: 10.3390/antiox13080998.

Pharmacological blockade of 2-AG degradation ameliorates clinical, neuroinflammatory and synaptic alterations in experimental autoimmune encephalomyelitis.
Guadalupi L, Mandolesi G, Vanni V, Balletta S, Caioli S, Pavlovic A, De Vito F, Fresegna D, Sanna K, Vitiello L, Nencini M, Tartacca A, Mariani F, Rovella V, Schippling S, Ruf I, Collin L, Centonze D, Musella A.
NEUROPHARMACOLOGY. 2024;252. doi: 10.1016/j.neuropharm.2024.109940.

Preliminary spectroscopic investigation of a potential Mars analog site: Lake Bagno dell'Acqua, Pantelleria, Italy.
Bruschini E, Ferrari M, Mazzoni C, Fazi S, Chiocci FL, Mazzini I, Costanzo G, De Angelis S, De Sanctis MC, Altieri F, Brossier J, Ammannito E.
PLANETARY AND SPACE SCIENCE. 2024;245. doi: 10.1016/j.pss.2024.105893.

Preserving Genome Integrity: Unveiling the Roles of ESCRT Machinery.
La Torre M, Burla R, Saggio I.
CELLS. 2024;13(15). doi: 10.3390/cells13151307.

Preventive exercise and physical rehabilitation promote long‐term potentiation‐like plasticity expression in patients with multiple sclerosis.
Bassi S, Gilio M, Buttari L, Dolcetti F, Bruno E, Galifi A, Azzolini G, Borrelli F, Mandolesi A, Gentile G, Antonietta, De Vito, Musella F, Simonelli A, Centonze I, Iezzi D, Ennio.
EUROPEAN JOURNAL OF NEUROLOGY. 2024;31(3). doi: 10.1111/ene.16071.

Pursuing Polypharmacology: Benzothiopyranoindoles as G-Quadruplex Stabilizers and Topoisomerase I Inhibitors for Effective Anticancer Strategies.
Salerno S, Barresi E, Roggia M, Natale B, Marzano S, Hyeraci M, Reina SCR, Baglini E, Amato J, Salvati E, Dalla Via L, Da Settimo F, Cosconati S, Taliani S.
ACS MEDICINAL CHEMISTRY LETTERS. 2024;15(11):1875-1883. doi: 10.1021/acsmedchemlett.4c00313.

Re-emergence of T lymphocyte-mediated synaptopathy in progressive multiple sclerosis.
Sanna K, Bruno A, Balletta S, Caioli S, Nencini M, Fresegna D, Guadalupi L, Dolcetti E, Azzolini F, Buttari F, Fantozzi R, Borrelli A, Stampanoni Bassi M, Gilio L, Lauritano G, Vanni V, De Vito F, Tartacca A, Mariani F, Rovella V, Musella A, Centonze D, Mandolesi G.
FRONTIERS IN IMMUNOLOGY. 2024;15. doi: 10.3389/fimmu.2024.1416133.

Self-Assembled Materials Based on Fully Aromatic Peptides: The Impact of Tryptophan, Tyrosine, and Dopa Residues.
Balasco N, Altamura D, Scognamiglio PL, Sibillano T, Giannini C, Morelli G, Vitagliano L, Accardo A, Diaferia C.
LANGMUIR. 2024;40(2):1470-1486. doi: 10.1021/acs.langmuir.3c03214.

Short-Term Memory Deficit Associates with miR-153-3p Upregulation in the Hippocampus of Middle-Aged Mice.
Stabile F, Torromino G, Rajendran S, Del Vecchio G, Presutti C, Mannironi C, De Leonibus E, Mele A, Rinaldi A.
MOLECULAR NEUROBIOLOGY. 2024;61(5):3031-3041. doi: 10.1007/s12035-023-03770-5.

Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain.
Denaro S, Pasquinucci L, Turnaturi R, Alberghina C, Longhitano L, Giallongo S, Costanzo G, Spoto S, Grasso M, Zappala A, Li Volti G, Tibullo D, Vicario N, Parenti R, Parenti C.
MOLECULAR NEUROBIOLOGY. 2024;61(5):2672-2685. doi: 10.1007/s12035-023-03717-w.

SIRT1 Serum Concentrations in Lipodystrophic Syndromes.
Salvatori L, Magno S, Ceccarini G, Tozzi R, Contini S, Pelosini C, Santini F, Gnessi L, Mariani S.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(9). doi: 10.3390/ijms25094785.

Sorcin in Cancer Development and Chemotherapeutic Drug Resistance.
Exertier C, Antonelli L, Fiorillo A, Bernardini R, Colotti B, Ilari A, Colotti G.
Cancers (Basel). 2024 Aug 9;16(16):2810. doi: 10.3390/cancers16162810.

Staphylococcus aureus colonizing the skin microbiota of adults with severe atopic dermatitis exhibits genomic diversity and convergence in biofilm traits.
Sivori F, Cavallo I, Truglio M, De Maio F, Sanguinetti M, Fabrizio G, Licursi V, Francalancia M, Fraticelli F, La Greca I, Lucantoni F, Camera E, Mariano M, Ascenzioni F, Cristaudo A, Pimpinelli F, Di Domenico EG.
BIOFILM. 2024;8. doi: 10.1016/j.bioflm.2024.100222.

Structural and Dynamic-Based Characterization of the Recognition Patterns of E7 and TRP-2 Epitopes by MHC Class I Receptors through Computational Approaches.
Balasco N, Tagliamonte M, Buonaguro L, Vitagliano L, Paladino A.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(3). doi: 10.3390/ijms25031384.

Structural studies of KCTD1 and its disease-causing mutant P20S provide insights into the protein function and misfunction.
Balasco N, Ruggiero A, Smaldone G, Pecoraro G, Coppola L, Pirone L, Pedone EM, Esposito L, Berisio R, Vitagliano L.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2024;277(Pt 4). doi: 10.1016/j.ijbiomac.2024.134390.

Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1.
Spizzichino S, Di Fonzo F, Marabelli C, Tramonti A, Chaves-Sanjuan A, Parroni A, Boumis G, Liberati FR, Paone A, Montemiglio LC, Ardini M, Jakobi AJ, Bharadwaj A, Swuec P, Tartaglia GG, Paiardini A, Contestabile R, Mai A, Rotili D, Fiorentino F, Macone A, Giorgi A, Tria G, Rinaldo S, Bolognesi M, Giardina G, Cutruzzolà F.
Mol Cell. 2024 Jul 25;84(14):2682-2697.e6. doi: 10.1016/j.molcel.2024.06.016.

Synthesis of photoluminescent 2D self-assembled silver thiolate nanoclusters for sensors and biomolecule support.
Caschera D, Brugnoli B, Primitivo L, De Angelis M, Righi G, Pilloni L, Campi G, Imperatori P, Pentimalli M, Masi A, Liscio A, Rea G, Suber L.
Inorg Chem. 2024 Feb 26;63(8):3724-3734. doi: 10.1021/acs.inorgchem.3c03738.

Targeted allele-specific FGFR2 knockdown via human recombinant ferritin nanoparticles for personalized treatment of Crouzon syndrome.
Tiberio F, Salvati M, Polito L, Tisci G, Vita A, Parolini O, Massimi L, Di Pietro L, Ceci P, Tamburrini G, Arcovito A, Falvo E, Lattanzi W.
MOLECULAR THERAPY NUCLEIC ACIDS. 2024;(1). doi: 10.1016/j.omtn.2024.102427.

Targeting staphylococcal enterotoxin B binding to CD28 as a new strategy for dampening superantigen-mediated intestinal epithelial barrier dysfunctions.
Amormino C, Russo E, Tedeschi V, Fiorillo MT, Paiardini A, Spallotta F, Rosanò L, Tuosto L, Kunkl M.
FRONTIERS IN IMMUNOLOGY. 2024;15. doi: 10.3389/fimmu.2024.1365074.

Telomeres: an organized string linking plants and mammals.
DI PIETRO E, Burla R, LA TORRE M, González-García MP, DELLO IOIO R, Saggio I.
BIOLOGY DIRECT. 2024;(1). doi: 10.1186/s13062-024-00558-y.

The COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives.
Gaetano C, Atlante S, Gottardi Zamperla M, Barbi V, Gentilini D, Illi B, Malavolta M, Martelli F, Farsetti A.
GEROSCIENCE. 2024;(1). doi: 10.1007/s11357-024-01406-7.

The genomic portrait of the Picene culture provides new insights into the Italic Iron Age and the legacy of the Roman Empire in Central Italy.
Ravasini F, Kabral H, Solnik A, de Gennaro L, Montinaro F, Hui R, Delpino C, Finocchi S, Giroldini P, Mei O, Beck De Lotto MA, Cilli E, Hajiesmaeil M, Pistacchia L, Risi F, Giacometti C, Scheib CL, Tambets K, Metspalu M, Cruciani F, D'Atanasio E, Trombetta B.
GENOME BIOLOGY. 2024;25(1). doi: 10.1186/s13059-024-03430-4.

The impact of oxidative stress on the epigenetics of fetal alcohol spectrum disorders.
Terracina S, Tarani L, Ceccanti M, Vitali M, Francati S, Lucarelli M, Venditti S, Verdone L, Ferraguti G, Fiore M.
Antioxidants (Basel). 2024 Mar 28;13(4):410. doi: 10.3390/antiox13040410.

The Ins and Outs of Homeodomain-Leucine Zipper/Hormone Networks in the Regulation of Plant Development.
Sessa G, Carabelli M, Sassi M.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(11). doi: 10.3390/ijms25115657.

The ubiquitous pyridoxal 5′‐phosphate‐binding protein is also an RNA‐binding protein.
Graziani C, Barile A, Parroni A, di Salvo ML, De Cecio I, Colombo T, Babor J, de Crécy‐Lagard V, Contestabile R, Tramonti A.
PROTEIN SCIENCE. 2024;33(12). doi: 10.1002/pro.5242.

The Z isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target.
Graziani C, Barile A, Antonelli L, Fiorillo A, Ilari A, Vetica F, di Salvo ML, Paiardini A, Tramonti A, Contestabile R.
THE FEBS JOURNAL. 2024;(22). doi: 10.1111/febs.17274.

The alpha-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases.
Iuzzolino A, Pellegrini FR, Rotili D, Degrassi F, Trisciuoglio D.
Cell Mol Life Sci. 2024 Apr 23;81(1):193. doi: 10.1007/s00018-024-05227-x.

The beta-arrestin1/endothelin axis bolsters ovarian fibroblast-dependent invadosome activity and cancer cell metastatic potential.
Del Rio D, Masi I, Caprara V, Ottavi F, Albertini Petroni G, Salvati E, Trisciuoglio D, Giannitelli SM, Bagnato A, Mauri E, Spadaro F, Rosanò L.
Cell Death Dis. 2024 May 22;15(5):358. doi: 10.1038/s41419-024-06730-6.

Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer.
Neeb A, Figueiredo I, Bogdan D, Cato L, Stober J, Jiménez-Vacas JM, Gourain V, Lee II, Seeger R, Muhle-Goll C, Gurel B, Welti J, Nava Rodrigues D, Rekowski J, Qiu X, Jiang Y, Di Micco P, Mateos B, Bielskutė S, Riisnaes R, Ferreira A, Miranda S, Crespo M, Buroni L, Ning J, Carreira S, Bräse S, Jung N, Gräßle S, Swain A, Salvatella X, Plymate SR, Al-Lazikani B, Long HW, Yuan W, Brown M, Cato ACB, de Bono JS, Sharp A.
MOLECULAR CANCER THERAPEUTICS. 2024;23(6). doi: 10.1158/1535-7163.MCT-23-0354.

To erase or not to erase: non-canonical catalytic functions and non-catalytic functions of members of histone lysine demethylase families.
Di Nisio E, Manzini V, Licursi V, Negri R.
Int J Mol Sci. 2024 Jun 24;25(13):6900. doi: 10.3390/ijms25136900.

Unusual Age-Dependent Behavior of Leukocytes Telomere Length in Friedreich's Ataxia.
Scarabino D, Veneziano L, Nethisinghe S, Mantuano E, Fiore A, Granata G, Solanky N, Zanni G, Cavalcanti F, Corbo RM, Giunti P.
MOVEMENT DISORDERS. 2024;(11). doi: 10.1002/mds.29976.

Using art and history to communicate immunology to a broad audience.
Di Rosa F.
Nat Rev Immunol. 2024 Sep 16. doi: 10.1038/s41577-024-01090-w.

Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila.
Pilesi E, Tesoriere G, Ferriero A, Mascolo E, Liguori F, Argirò L, Angioli C, Tramonti A, Contestabile R, Volonté C, Vernì F.
CELL DEATH & DISEASE. 2024;15(6). doi: 10.1038/s41419-024-06787-3.

YAP signaling orchestrates the endothelin-1-guided invadopodia formation in high-grade serous ovarian cancer.
Tocci P, Caprara V, Roman C, Sestito R, Rosano' L, Bagnato A.
BIOSCIENCE REPORTS. 2024;(12). doi: 10.1042/BSR20241320.

Zwitterionic nanoparticles for thermally activated drug delivery in hyperthermia cancer treatment.
Colli C, Masi I, Jacchetti E, Santoni S, Sponchioni M, Colosimo BM, Rosanò L, Raimondi MT, Mauri E, Moscatelli D.
NANOSCALE. 2024;16(26):12635-12649. doi: 10.1039/d4nr00723a.