• Istituto di Biologia e Patologia Molecolari

The Institute of Molecular Biology and Pathology (IBPM) develops research in fundamental biology, with biotechnological applications in biomedicine, the environment and agrifood using interdisciplinary and multidisciplinary approaches.

IBPM laboratories are hosted within Sapienza University of Rome




Teresa Colombo

go to video


‘Immunology: the charme of diversity’

23 october - 9 november 2023
CNR headquarters, Roma

The COVID-19 I-book

A project co-edited by Barbara Illi and Valeria Poli
go to: Barbara Illi’s interview





MISSION    The IBPM develops research in the following areas

  • Structural bases of protein and nucleic acid function, particularly in regulation of the expression of genes and genomes, of structural and regulatory proteins, and of molecules involved in the immune response;
  • Molecular mechanisms of evolution and differentiation in animal and plants and biotechnological and biomedical applications;
  • Design, synthesis, biosynthesis, purification and characterization of biologically active molecules: development of innovative chemical and molecular methods; characterization of their mechanisms of action; implications in human health.


Tom Wahlig Foundation for spastic hereditary paraplegy
Francesca Sardina

DSB-CNR awards to starting scientists
Eugenia D'Atanasio
Anna Frappaolo

Fondazione Veronesi research fellowship
Francesca Sardina

Rome city council award “RomaRose - Non solo 8 marzo”
Rossella Lucà

go to awards


Nose-to-brain selective drug delivery to glioma via ferritin-based nanovectors reduces tumor growth and improves survival rate.
Marrocco F, et al. Cell Death Dis. 2024 Apr 13

Cul-4 inhibition rescues spastin levels and reduces defects in hereditary spastic paraplegia models.
Sardina F, et al. Brain. 2024 Mar 29

Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis.
Exertier C, et al.. J Med Chem. 2024 Jan 11

The genomic echoes of the last Green Sahara on the Fulani and Sahelian people
E. D'Atanasio et al. Curr Biology 2023

HAX1 is a novel binding partner of Che-1/AATF. Implications in oxidative stress cell response
Pisani C et al. Biochim Biophys Acta Mol Cell Res. 2024 Jan

The long noncoding RNA nHOTAIRM1 is necessary for differentiation and activity of iPSC-derived spinal motor neurons
Tollis P et al. Cell Death Dis. 2023

PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment.
Maresca C et al. Commun Biol 2023

AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation.
Asteriti IA et al. Life Sci Alliance 2023

The interaction of ß-arrestin1 with talin1 driven by endothelin A receptor as a feature of a5ß1 integrin activation in high-grade serous ovarian cancer.
Masi I et al. Cell Death Dis 2023

Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production.

Pellegrini et al. Autophagy. 2023

The full-length Auxin Response Factor 8 isoform ARF8.1 controls pollen cell wall formation and directly regulates TDF1, AMS and MS188 expression.
Ghelli et al. Plant J. 2023

Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells.
Ansari et al. Cancer Gene Ther. 2023