Istituto di Biologia e Patologia Molecolari CNR - Consiglio Nazionale delle Ricerche
 
 
EVENTS
 
 
 
 
 
 
NEWS

Press release 29/09/2025
A new key gene for heart health discovered
Pietro Laneve

Featured image, FocalPlane, 15/08/2025
Ludovica Altieri

Calls and positions

Calls
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Thesis projects
 
 
MISSION    The IBPM develops research in the following areas
  • Structural bases of protein and nucleic acid function, particularly in regulation of the expression of genes and genomes, of structural and regulatory proteins, and of molecules involved in the immune response;
  • Molecular mechanisms of evolution and differentiation in animal and plants and biotechnological and biomedical applications;
  • Design, synthesis, biosynthesis, purification and characterization of biologically active molecules: development of innovative chemical and molecular methods; characterization of their mechanisms of action; implications in human health.
 

The Institute of Molecular Biology and Pathology (IBPM) develops research in fundamental biology, with biotechnological applications in biomedicine, the environment and agrifood using interdisciplinary and multidisciplinary approaches.

IBPM laboratories are hosted within Sapienza University of Rome



The CNR Structural Biology Network
CNR Structural Biology Network

 
IBPM HIGHLIGHTS
 
 
 
 
RESEARCH AWARDS

From Pantelleria to Mars. In a Sicilian lake, the origin of life is being explored
Giovanna Costanzo

EuroSPG4 Project on YouTube
The project “Spastin recovery as a new therapeutic approach for Hereditary Spastic Paraplegia (HSP)” selected for the fundraising campaign of Euro-HSP, the European Federation of HSP patients
Cinzia Rinaldo

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Tom Wahlig Foundation for spastic hereditary paraplegy
Francesca Sardina

DSB-CNR awards to starting scientists
Eugenia D'Atanasio
Anna Frappaolo

go to awards
 
 
RECENT PUBLICATIONS

α-tubulin N-acetyltransferase 1 regulates NCOA4-mediated ferritinophagy and protects cancer cells from ferroptosis.
Pellegrini FR, Iuzzolino A, et al. D. Cell Mol Biol Lett. 2026 Jun 12. doi: 10.1186/s11658-026-00964-2. Epub ahead of print. PMID: 42286479.

The ATC12 small molecule inhibits the Aurora-A/TPX2 interaction and impairs the proliferation of breast cancer cells.
Boi D, Fianco G, Polverino F et al. Cell Death Dis. 2026 Mar 24;17(1):356. doi: 10.1038/s41419-026-08579-3.

LncRNA HSCHARME is altered in human cardiomyopathies and promotes stem cell-derived cardiomyogenesis via splicing regulation.
Buonaiuto G, Desideri F, et al. Nat Commun. 2025;16(1):7880. doi: 10.1038/s41467-025-62754-2.

Fast, Comprehensive, and User Customizable Macromolecule Interface Analysis with FACE2FACE.
Di Micco P, Incarnato M, et al. J Chem Inf Model. 2025. doi: 10.1021/acs.jcim.5c00771.

The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts
Masi I, Ottavi F, et al. J Exp Clin Cancer Res. 2025. doi: 10.1186/s13046-025-03327-5.

Cytoplasmic accumulation of a splice variant of hnRNPA2/B1 contributes to FUS-associated toxicity in a mouse model of ALS.
Rossi S, Milani M, et al. Cell Death Dis. 2025 Mar 29;16(1):219. doi: 10.1038/s41419-025-07538-8.