• Istituto di Biologia e Patologia Molecolari

Publications 2013

Arciello M, Gori M, Maggio R, Barbaro B, Tarocchi M, Galli A, Balsano C.
Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis.
Int J Mol Sci. 2013 Nov 7;14(11):22052-66.

Morlando M, Rosa A, Caffarelli E , Fatica A and I Bozzoni
Non coding RNA in muscle differentiation and disease.
microRNA Journal (in press). 2013
Di Carlo V, Grossi E, Laneve P, Morlando M, Dini Modigliani S, Ballarino M, Bozzoni I, Caffarelli E
TDP-43 Regulates the Microprocessor Complex Activity during in vitro Neuronal Differentiation
Molecular Neurobiology (in press). 2013

Kostiainen MA, Hiekkataipale P, Laiho A, Lemieux V, Seitsonen J, Ruokolainen J, Ceci P.
Electrostatic assembly of binary nanoparticle superlattices using protein cages.
Nat Nanotechnol. 2013 Jan;8(1):52-6. doi: 10.1038/nnano.2012.220

Abenavoli L, Scarpellini E, Rouabhia S, Balsano C, Luzza F.
Probiotics in non-alcoholic fatty liver disease: which and when.
Ann Hepatol. 2013; 12: 357-363.
Arciello M, Balsano C.
Pathogenesis of hepatocellular carcinoma: new ideas for a targeted therapy. Hot Topics in Viral Hepatitis. Sex, liver disease, and response to antiviral therapy
Women in hepatology – 2nd ed. 2013; 27.
Conti B, Minutolo A, Arciello M, Balsano C.
Are Hedgehog and Wnt/ß-catenin pathways involved in hepatitis C virus-mediated EMT?
J Hepatol. 2013; 58: 636-637. 

Tiziana Santini, Luana Turchi, Giulia Ceccarelli, Carmen Di Franco, Elena Beccari
Transcriptional analysis of ftsZ within the dcw cluster in Bacillus mycoides
BMC Microbiol. ; 13 (1): 27

Di Silvio, E., Di Matteo A., Malatesta F., Travaglini-Allocatelli C.
Recognition and binding of apocytochrome c to to P. aeruginosa CcmI, a component of cytochrome c maturation machinery.
Biochim Biophys Acta.  Article in press.

Chiarella, S., Federici, L., Di Matteo, A., Brunori, M., Gianni, S.
The folding pathway of a functionally competent C-terminal domain of nucleophosmin: Protein stability and denatured state residual structure
Biochemical and Biophysical Research Communications;  35: 64-8

Chiarella, S., De Cola, A., Scaglione, G.L., Carletti, E., Graziano, V., Barcaroli, D., Lo Sterzo, C., Di Matteo, A., Di Ilio, C., Falini, B., Arcovito, A., De Laurenzi, V., Federici, L.
Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA
Nucleic Acids Research;  41 (5):  3228-3239.

R. Saladino ,  G. Botta ,  S. Pino ,  G. Costanzo, E. Di Mauro
Materials for the Onset. A story of necessity and chance.  
Frontiers In Bioscience;  18:  1275-1289

E. Di Mauro, R. Saladino , E. N. Trifonov
The path to Life`s origins. Remaining hurdles.
Journal Of Biomolecular Structure & Dynamics; ahead of print

V.B.Borisov, E.Forte, A.Davletshin, D.Mastronicola, P.Sarti and A.Giuffrè
Cytochrome bd Oxidase from Escherichia coli displays high catalase activity: an additional defense against oxidative stress
FEBS Lett. ;  in press.

N.Krako, M.C.Magnifico, M.Arese, G.Meli, E.Forte, A.Lecci, A.Manca, A.Giuffrè, D.Mastronicola, P.Sarti and A.Cattaneo
Characterization of mitochondrial dysfunctions in the 7PA2 cell model of Alzheimer’s Disease
J. Alzheimers Dis.;  in press.

P.Sarti, M.C.Magnifico, F.Altieri, D.Mastronicola and M.Arese
New evidence for cross talk between melatonin and mitochondria mediated by a circadian-compatible interaction with nitric oxide.
Int J Mol Sci. ; 14:  11259-76.

Federman N, de la Fuente V, Zalcman G, Corbi N, Onori A, Passananti C, Romano A.
Nuclear factor kB-dependent histone acetylation is specifically involved in persistent forms of memory.
J Neurosci.; 33(17):  7603-14

Onori A, Pisani C, Strimpakos G, Monaco L, Mattei E, Passananti C, Corbi N.
UtroUp is a novel six zinc finger artificial transcription factor that recognises 18 base pairs of the utrophin promoter and efficiently drives utrophin upregulation.
BMC Mol Biol.;  14: 3.

Zampieri M, Guastafierro T, Calabrese R; Ciccarone F, Bacalini MG, Reale A, Perilli M, Passananti C, Caiafa P.
ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites.
Biochem J. 2012;441(2): 645-52.

De Girolamo L, Stanco D, Salvatori L, Coroniti G, Arrigoni E, Silecchia G, Russo MA, Niada S, Petrangeli E, Brini AT.
Stemness and osteogenic and adipogenic potential are differently impaired in subcutaneous and visceral adipose derived stem cells (ASCs) isolated from obese donors.
Int J Immunopathol Pharmacol.;  26 (1 Suppl).
Tafani M, Pucci B, Russo A, Schito L, Pellegrini L, Perrone GA, Villanova L, Salvatori L, Ravenna L, Petrangeli E, Russo MA.
Modulators of HIF1a and NFkB in Cancer Treatment: Is it a Rational Approach for Controlling Malignant Progression
Front Pharmacol.;  4: 13.
Sylvain Robin, Marzia Arese, Elena Forte, Paolo Sarti, Olga Kolaj-Robin, Alessandro Giuffrè, Tewfik Soulimane.  
Functional Dissection of the Multi-Domain Di-Heme Cytochrome c550 from Thermus thermophilus.
PloS one; e55129

Cecchetti V, Altamura MM, Brunetti P, Petrocelli V, Falasca G, Ljung K, Costantino P, Cardarelli M. 
Auxin controls Arabidopsis anther dehiscence by regulating endothecium lignification and jasmonic acid biosynthesis.
Plant J., 74:411-422.

Lubrano C, Genovesi G, Specchia P, Costantini D, Mariani S, Petrangeli E, Lenzi A, Gnessi L.
Obesity and metabolic comorbidities: environmental diseases?
Oxid Med Cell Longev. 2013;2013:640673.
Tafani M, Pucci B, Russo A, Schito L, Pellegrini L, Perrone GA, Villanova L, Salvatori L, Ravenna L, Petrangeli E, Russo MA.
Modulators of HIF1a and NFkB in Cancer Treatment: Is it a Rational Approach for Controlling Malignant Progression?
Front Pharmacol. 2013 Feb 12;4:13.
Manganaro L, Michienzi S, Vinci V, Falzarano R, Saldari M, Granato T., Viggiani V, Frati L, Anastasi E.
Serum level combined with CE CT imaging improves the monitoring management of woman affected by epithelial ovarian cancer.
ONCOLOGY REPORTS, ISSN: 1791-2431. 2013; doi: 10.3892/or.2013.2682.
Anastasi E, Granato T., Falzarano R, Storelli P, Ticino A, Frati L, Benedetti Panici PL, Porpora MG
The use of HE4, CA125 and CA72-4 biomarkers for differential diagnosis between ovarian cancer, ovarian endometrioma and other benign ovarian masses.
JOURNAL OF OVARIAN RESEARCH, vol. 6, ISSN: 1757-2215. 2013; doi: 10.1186/1757-2215-6-44.
Anastasi E, Manganaro L, Granato T., Benedetti Panici PL, Frati L, Porpora MG
Is CA72.4 a useful biomarker in differential diagnosis between ovarian endometrioma and epithelial ovarian cancer?.
DISEASE MARKERS, vol. 35; p. 331-335, ISSN: 0278-0240. 2013; doi: 10.1155/2013/984641.
Arabidopsis HD-Zip II transcription factors control apical embryo development and meristem function.
Turchi L, Carabelli M, Ruzza V, Possenti M, Sassi M, Peñalosa A, Sessa G, Salvi S, Forte V, Morelli G, Ruberti I.
Development. 2013 May;140(10):2118-29 
The bHLH proteins BEE and BIM positively modulate the shade avoidance syndrome in Arabidopsis seedlings.
Cifuentes-Esquivel N, Bou-Torrent J, Galstyan A, Gallemí M, Sessa G, Salla Martret M, Roig-Villanova I, Ruberti I, Martínez-García JF.
Plant J. 2013 Sep;75(6):989-1002. 
Dynamics of the shade-avoidance response in Arabidopsis.
Ciolfi A, Sessa G, Sassi M, Possenti M, Salvucci S, Carabelli M, Morelli G, Ruberti I.
Plant Physiol. 2013 Sep;163(1):331-53. 
Giri R, Morrone A, Toto A, Brunori M, Gianni S
Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system.
Proc Natl Acad Sci U S A. 2013; 110, 149422-149427
Eildal JN, Hultqvist G, Balle T, Stuhr-Hansen N, Padrah S, Gianni S, Strømgaard K, Jemth P.
Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations. 
J. Am. Chem. Soc. 2013; 135, 12998-13007
V.Bahadur*, D.Mastronicola*, H.K.Tiwari, Y.Kumar, M.Falabella, L.P.Pucillo, P.Sarti, A.Giuffrè, B.K.Singh
O2-dependent efficacy of novel piperidine/piperazine-based chalcones against the human parasite.
Giardia intestinalis Antimicrob Agents Chemother 2013 Nov 11. 
Colotti G, Baiocco P, Fiorillo A, Boffi A, Poser E, Chiaro FD, Ilari A.
Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs. 
Future Med Chem. 2013;5:1861-75 
Colotti G, Ilari A, Fiorillo A, Baiocco P, Cinellu MA, Maiore L, Scaletti F, Gabbiani C, Messori L.
Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes. 
Chem. Med. Chem. 2013 Aug 23. 
Baiocco P, Poce G, Alfonso S, Cocozza M, Porretta GC, Colotti G, Biava M, Moraca F, Botta M, Yardley V, Fiorillo A, Lantella A, Malatesta F, Ilari A.
Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography. 
Chem. Med. Chem. 2013, 8:1175-83. 
Ardini M, Fiorillo A, Fittipaldi M, Stefanini S, Gatteschi D, Ilari A, Chiancone E.
Kineococcus radiotolerans Dps forms a heteronuclear Mn-Fe ferroxidase center that may explain the Mn-dependent protection against oxidative stress. 
Biochim Biophys Acta. 2013, 1830:3745-55. 
Trnková L, Ricci D, Grillo C, Colotti G, Altieri F.
Green tea catechins can bind and modify ERp57/PDIA3 activity.
Biochim Biophys Acta. 2013; 1830: 2671-82. 
P. Sarti, M.C.Magnifico, F.Altieri, D.Mastronicola, M.Arese
New Evidence for Cross Talk between Melatonin and Mitochondria Mediated by a Circadian-Compatible Interaction with Nitric Oxide.
Int J Mol Sci. 2013;14:11259-76.
Ilari A, Alaleona F, Tria G, Petrarca P, Battistoni A, Zamparelli C, Verzili D, 
interaction with the high-affinity uptake protein ZnuA provide insight into the management of periplasmic zinc.
Biochim Biophys Acta. 2013;1840:535-544. 
Fiorini A, Koudriavtseva T, Bucaj E, Coccia R, Foppoli C, Giorgi A, Schininà ME, Di Domenico F, De Marco F, Perluigi M.
Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis.
PLoS One. 2013; 8(6): e65184, pag.1-12
Falvo E, Tremante E, Fraioli R, Leonetti C, Zamparelli C, Boffi A, Morea V, Ceci P, Giacomini P.
Antibody-drug conjugates: targeting melanoma with cisplatin encapsulated in protein-cage nanoparticles based on human ferritin.
Nanoscale. 2013; Oct 23. DOI: 10.1039/C3NR04268E
Colotti G, Ilari A, Boffi A, Morea V. Metals and Metal derivatives in Medicine. 
Mini Rev Med Chem. 2013, 13: 211-221.
Ascenzi, P., and Gianni S.
On the functional role of reaction intermediates: rediscovering "chronosteric effects" thirty years later.
IUBMB Life, 2013; 65, 836-844
Perli E, Giordano C, Pisano A, Montanari A, Campese AF, Reyes A, Ghezzi D, Nasca A, Tuppen HA, Orlandi M, Di Micco P, Poser E, Taylor RW, Colotti G, Francisci S, Morea V, Frontali L, Zevianoi M, d’Amati G. 
The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells.
EMBO Mol Med. 2013; 

Fiore M, Mattiuzzo M, Mancuso G, Totta P, Degrassi F. (2013).
The pesticide dichlorvos disrupts mitotic division by delocalizing the kinesin Kif2a from centrosomes.
Environ Mol Mutagen. 54:250-260.
Basso E, Fiore M, Leone S, Degrassi F, Cozzi R. (2013).
Effects of resveratrol on topoisomerase II-a activity: induction of micronuclei and inhibition of chromosome segregation in CHO-K1 cells.
Mutagenesis 28: 243-248. 
Prodosmo A, De Amicis A, Nisticò C, Gabriele M, Di Rocco G, Monteonofrio L, Piane M, Cundari E, Chessa L, Soddu S. (2013).
p53 centrosomal localization diagnoses ataxia-telangiectasia homozygotes and heterozygotes.
J Clin Invest. 123: 1335-42. 
Sorino C, Bruno T, Desantis A, Di Certo MG, Iezzi S, De Nicola F, Catena V, Floridi A, Chessa L, Passananti C, Cundari E, Fanciulli M. (2013)
Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization.
J Biol Chem. 288: 23348-57.
Amato R, Scumaci D, D'Antona L, Iuliano R, Menniti M, Di Sanzo M, Faniello MC, Colao E, Malatesta P, Zingone A, Agosti V, Costanzo FS, Mileo AM, Paggi MG, Lang  F, Cuda G, Lavia P, Perrotti N. (2013).
Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells.
Oncogene. 32:4572-4578. 
La Regina G, Bai R, Rensen WM, Di Cesare E, Coluccia A, Piscitelli F, Famiglini V, Reggio A, Nalli M, Pelliccia S, Da Pozzo E, Costa B, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Santoni A, Li J, Miranda Cona M, Chen F, Ni Y, Brancale A, Dondio G, Vultaggio S, Varasi M, Mercurio C, Martini C, Hamel E, Lavia P, Novellino E, Silvestri R. (2013).
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.
J Med Chem 56:123-149. 
De Turris V., Guarguaglini G. and Lavia P. (2013)
Immunofluorescence Methods in Studies of the GTPase RAN and Its Effectors in Interphase and in Mitotic Cells. In Ras Signaling: Methods and Protocols
Meth Mol Biol, vol. 1120, DOI 10.1007/978-1-62703-791-4-16 (in press)
Piersanti S, Tagliafico E, Saggio I. (2013)
DNA microarray to analyze adenovirus-host interactions.
Methods Mol Biol. 1089: 89-104. 
Piersanti S, Astrologo L, Licursi V, Costa R, Roncaglia E, Gennetier A, Ibanes S, Chillon M, Negri R, Tagliafico E, Kremer EJ, Saggio I. (2013)
PLoS One. 8(7):e69808. 
Guan XL, Cestra G, Shui G, Kuhrs A, Schittenhelm RB, Hafen E, Gisou van der Goot F, Robinett CC, Gatti M, Gonzalez-Gaitan M, Wenk MR. (2013).
Biochemical membrane lipidomics during Drosophila development. Dev. Cell, 24: 98-111
Raffa GD, Cenci G, Ciapponi L, Gatti M. (2013).
Organization and evolution of Drosophila terminin: similarities and differences between Drosophila and human telomeres.
Frontiers in Oncology. 3: 112/7 (invited review). 
Cipressa F, Romano S, Centonze S, zur Lage PI, Vernì F, Dimitri P, Gatti M, Cenci G. (2013).
Effete, a Drosophila chromatin-associated ubiquitin-conjugating enzyme that affects both telomere- and heterochromatin-induced position effect variegation.
Genetics 195: 147-58
Raffa GD, Cenci G, Ciapponi L, Gatti M. (2013)
Organization and maintenance of Drosophila telomeres: the roles of terminin and non-terminin proteins.
Tsitologiia. 55: 204-208 (invited review).
Lee H, McManus CJ, Cho DY, Eaton M, Renda F, Somma MP, Cherbas L, May G, Powell S, Zhang D, Zhan L, Resch A, Andrews J,  Celniker S, Cherbas P, Przytycka TM, Gatti M, Oliver B, Graveley B, MacAlpine D. (2013).
DNA copy number evolution in Drosophila modENCODE cell lines.
Genome Biology, in press
Marzio A, Merigliano C, Gatti M, Vernì F. (2013)
Sugar and chromosome stability: Clastogenic effects of sugars in vitamin B6-deficient cells
PLoS Genetics, in press