Tel :
Fax :
fabrizio.antonangeli@cnr.it
Fax :
fabrizio.antonangeli@cnr.it
FABRIZIO ANTONANGELI
Researcher
Institute of Molecular Biology and Pathology - National Research Council
Department of Molecular Medicine
Sapienza University of Rome - Viale Regina Elena 291 Rome 00161
Researcher
Institute of Molecular Biology and Pathology - National Research Council
Department of Molecular Medicine
Sapienza University of Rome - Viale Regina Elena 291 Rome 00161
| I am interested in studying the mechanisms that regulate cellular stress and tissue homeostasis, in particular focusing on: - The role of cellular senescence as stress response. - The immune response of Natural Killer (NK) cells against drug-induced senescent tumor cells. - The molecular pathways (apoptosis, NF-κB) that regulate cell stress response. - Microbiota and NK cell cross-talk. |
| 1) Antonangeli F et al., Front Immunol 2020 2) D’Alessandro G*, Antonangeli F* et al., Eur J Immunology 2020 May;50(5):705-711 *contributed equally 3) Antonangeli F et al., J Leukoc Biol 2019 Jun;105(6):1275-1283 4) Antonangeli F et al., Front Immunol 2017 Nov 20;8:1583 5) Antonangeli F et al., OncoImmunology 2016 Aug 5;5(10):e1218105 6) Ponzetta A, Benigni G, Antonangeli F et al., Cancer Res 2015 Nov 15;75(22):4766-77 7) Rossi M and Antonangeli F Mediators Inflamm 2015;2015:259325 8) Rossi M and Antonangeli F Int J Cell Biol 2014;2014:473857 |
| WithIn IBPM Dr.ssa Francesca Di Rosa With IBPM Associate Members Prof.ssa Angela Santoni - Department of Molecular Medicine, Sapienza University of Rome With Other Institutions Prof.ssa Alessandra Soriani - Sapienza University of Rome Prof.ssa Cristina Limatola - Sapienza University of Rome |
| Education and Research Experiences • 2020-ongoing Researcher, National Research Council of Italy (CNR), Institute of Molecular Biology and Pathology • 2018-2019 Research Fellow, Sapienza University of Rome, Department of Molecular Medicine, Molecular Immunology and Immunopathology Laboratory • 2018 Fellowship from Istituto Pasteur Italia - Fondazione Cenci Bolognetti • 2011-2017 Research Associate at the Department of Molecular Medicine, Sapienza University of Rome, Molecular Immunology and Immunopathology Lab • 2010-2011 Research Associate at the University of Manchester, Faculty of Life Sciences • 2010 PhD in Cellular Sciences and Technologies, Sapienza University of Rome. Thesis title: “Novel roles of c-FLIP protein in tissue homeostasis” • 2004-2005 Fellowship at the Biology Department of University of Roma Tre • 2004 Graduated summa cum laude in Biological Sciences, University of Roma Tre. Thesis title: “Heterologous expression of mouse spermine oxidase site-directed mutants in E. coli” Grants - 2019 I have been awarded a 3,000 € grant from Sapienza University of Rome for the research project “The anti-tumor therapeutic efficacy of palbociclib is mediated by the induction of cellular senescence and its immune surveillance” - 2019 Author of a research project (40,000 € grant) regarding the administration of a pro-senescence drug for tumor immunotherapy approved by Pfizer Inc - 2016 I have been awarded a 2,000 € grant from Sapienza University of Rome for the research project “Role of p57 in the pathophysiology of multiple myeloma cells” Field of Expertise: Role of cellular senescence in tissue homeostasis and Natural Killer cell-mediated immune surveillance of tumor cells Skills and competences: Multi-parametric flow cytometry, Fluorescence and confocal microscopy, DNA-cloning and Real-Time PCR, Western blot, Cell culture, Animal care, NK cell biology (purification, de-granulation assay, NKG2D ligands), Cellular stress and senescence Publications: 24 peer-reviewed published articles (8 first author, 2 senior author, 7 review articles). Overall H-index (from Scopus): 11. Invited Guest Editor for the research topic “Cellular stress and inflammation: How the immune system drives tissue homeostasis” Frontiers in Immunology |