• Istituto di Biologia e Patologia Molecolari

PAOLA ROVELLA

Education
 
2015: MSc in Biology (bio-molecular programme) Calabria University, Rende, Italy.
2010: BSc in Biological Sciences, Calabria University, Rende, Italy.
 
Research experience
 
March 2018 - ongoing: Research fellow, Institute of Molecular Biology and Pathology (IBPM), CNR, Rome 
AIRC Project: The multifaceted Aurora-A/TPX2 complex in chromosome stability, tumorigenesis and anti-cancer therapy
 
June 2017-November 2017: Research fellow, Istitute Pasteur Italy-Fondazione Cenci Bolognetti, c/o Biology and Biotechnology Department “Charles Darwin”, University La Sapienza, Rome.
Project: Cytokinesis analysis after a knock-down of chromatin proteins in human cells.
 
October 2016-May 2017: Collaboration with Bionova Technologies s.r.l. at the Nikon microscopy reference Center for Southern and Central Italy, IBPM-CNR and Biology and Biotechnology Department “Charles Darwin”, University La Sapienza, Rome. 
Topic: New software development and optimisation in microscopy image acquisition and analysis. 
 
March 2016-September 2016: Post-graduate research training, IBPM-CNR
AIRC Project: Pharmacogenomics: methodological approaches to study anti-mitotic drugs and their modulation by endogenous genes in human cancer cells.
 
Pubblications 
 
-Verrico A., Rovella P., Di Francesco L., Damizia M., Sasah Staid D., Le Pera L., Schininà M.E., and Lavia P. Importin-ß/karyopherin-ß1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region. Oncogene (under revision) 
-La Regina G., Bai R., Coluccia A., Naccarato V., Famiglini V., Verrico A., Rovella P., Mazzoccoli C., Da Pozzo E., Cavallini C., Martini C., Vultaggio S., Dondio G., Varasi M., Mercurio C., Hamel E., Lavia P and Silvestri R. New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors. Eur J Med Chem. (2018) 152:283-297
 
-Di Francesco L.+, Verrico A.+, Asteriti IA, Rovella P., Cirigliano P., Guarguaglini G., Schininà M.E. and Lavia P. Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays. Sci Rep. (2018) 8:1850. 
 
-Di Cesare E., Verrico A., Miele A., Giubettini M., Rovella P., Coluccia A., Famiglini V., La Regina G., Cundari E., Silvestri R. and Lavia P. Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules. Oncotarget. (2017) 8:19738-19759. 
 
Keywords: nuclear trasport receptors, mitosis, anti-mitotic drugs, microscopy