• Istituto di Biologia e Patologia Molecolari

FRANCESCA SARDINA

EDUCATION
 
2015: PhD Degree in Medical Biotechnology, University of Siena.
2009: MSc Degree in Biotechnology for Industry and Scientific Research, University of Palermo.
2007: BSc Degree in Biotechnology, University of Palermo.
 
 
SCIENTIFIC POSITIONS AND RESEARCH EXPERIENCE
 
2018-2019 EMBO Short-Term fellow, Sheffield Institute for Translational Neuroscience - University of Sheffield (UK).
Project: “The HIPK2 kinase/spastin axis in Hereditary Spastic Paraplegia (HSP)”.
 
2017-2018: Postdoctoral fellow, CNR-Institute of Molecular Biology and Pathology (IBPM), Rome.
Project (Telethon): “The role of HIPK2 kinase in regulation of the spastin protein in proliferating cells and in neurons”.
 
2014-2016: Postdoctoral fellow, Dept. of Molecular Medicine, University La Sapienza, Rome.
Project (AIRC): “Role of the DNA damage response in hedgehog-MYCN dependent proliferation of cerebellar stem cells and granule precursor cells”.
 
2010-2014: PhD student, Dept. of Molecular Medicine, University La Sapienza, Rome.
PhD Thesis project: “The MRN complex controls MYCN-dependent replication stress and is a potential therapeutic target for MYCN-amplified neuroblastoma”.
 
2009-2010: Post-graduate research training, CNR-Institute of Biomedicine and Molecular Immunology (IBIM) Palermo.
Project: “The effects of the novel NF-?B inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in combination with the selective COX-2 inhibitor celecoxib, in human hepatoma cells”.
 
 
PUBLICATIONS
-M. Petroni*, F. Sardina*, P. Infante, A. Bartolazzi, E. Locatelli, F. Fabretti, S. Di Giulio, C. Capalbo, B. Cardinali, A. Coppa, A. Tessitore, V. Colicchia, M. Sahún-Roncero, F. Belardinilli, L. Di Marcotullio, S. Soddu, M. Comes Franchini, E. Petricci, A. Gulino, G. Giannini "MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors". Cell Death Dis,2018, 30;9(9):895. Impact factor 5.63. (*first co-authors)
-V. Colicchia, M. Petroni, G. Guarguaglini, F. Sardina, M. Sahun Roncero, M. Carbonari, B. Ricci, C. Heil, C. Capalbo, F. Belardinilli, A. Coppa, G. Peruzzi, I. Screpanti, P. Lavia, A. Gulino, G. Giannini “PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma" Oncogene, 2017, 36: 4682-4691. Impact factor 6.85.
- M. Petroni, F. Sardina, C. Heil, M. Sahún-Roncero, V. Colicchia, V. Veschi , S. Albini, D. Fruci,  B. Ricci, A. Soriani, L. Di Marcotullio, I. Screpanti, A. Gulino, G. Giannini “The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress”. Cell Death Differ.  2016, 23: 197-206. Impact factor 8.
-M. Cervello, D. Bachvarov, A. Cusimano, F. Sardina, A. Azzolina, L. Lampiasi, L. Giannitrapani, J.A. McCubrey, G. Montalto “COX-2-dependent and COX-2-independent mode of action of Celecoxib in human liver cancer cells”.  OMICS: Journal of Integrative Biology, 15:383-392. Impact factor 2.37.
 
Keywords: Neurobiology; Apoptosis; DNA Damage Response.