• Istituto di Biologia e Patologia Molecolari

The Institute

The IBPM is a strongly multidisciplinary research Institute hosted at Sapienza University, formed by 49 research scientists, 16 technical and administrative staff, and several fixed-term researchers, post-doctoral fellows, PhDs and graduate students. 


The IBPM develops cutting-edge research on complex biological processes by integrating a wide range of disciplines, including chemistry, molecular and cell biology, genetics, biochemistry, structural biology, bioinformatics, molecular pathology and immunology.
The multidisciplinarity of IBPM
The IBPM was founded in 2003 with the merging of three CNR Research Centres established at the University of Rome "La Sapienza":
-  the Centre of Molecular Biology, founded by Prof. Alessandro Rossi Fanelli in 1965, 
- the Centre of Evolutionary Genetics, started in 1969 under the direction of Prof. Giuseppe Montalenti, 
- the Centre of Nucleic Acids, founded in 1970 by Prof. Giorgio Tecce, its inspirational Director for over twenty years.  
In 2003, researchers from the former CNR Institute of Biomedical Technology (ITBM), active in translational research, also  joined the IBPM and formed the laboratory of Molecular Pathology.  
In 2013, a research unit from the CNR Institute of Biomolecular Chemistry (ICB) also joined, bringing to IBPM the expertise for in-house design and synthesis of relevant molecules.
Research interests
Major research areas at IBPM cover the design and synthesis of bioactive compounds, the characterization of macromolecules and cellular systems, and a wide range of genetic and molecular studies on animals and plants, including engineered organisms. 
IBPM has achieved important results in studies of the structure and function of nucleic acids and proteins, genetic and epigenetic mechanisms regulating gene expression and genome organization, control of cellular differentiation and cell division, the mechanisms of immune memory, and the interactions between organisms and the environment. A major strength is in the development of multidisciplinary strategies and diversified methodologies using highly informative model systems. Biotechnological and nanotechnological applications are being  pursued in the fields of human health, environment, agrifood. 
The location of IBPM within La Sapienza University fosters collaborations and scientific synergies with several University departments. Teaching and training activities are an integral part of the institute's life.

The IBPM develops research in the following areas:
• Structural bases of protein and nucleic acid function, particularly in regulation of the expression of genes and genomes, of structural and regulatory proteins, and of molecules involved in the immune response;
• Molecular mechanisms of evolution and differentiation in animal and plants and biotechnological and biomedical applications; 
• Design, synthesis, biosynthesis, purification and characterization of biologically active molecules: development of innovative chemical and molecular methods; characterization of their mechanisms of action; implications in human health.