• Istituto di Biologia e Patologia Molecolari

Publications 2019

Verrico A, Rovella P, Di Francesco L, Damizia M, Staid DS, Le Pera L, Schininà ME, Lavia P. 2019.
Importin-ß/karyopherin-ß1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region.
Oncogene 2019 Sep 6. doi: 10.1038/s41388-019-0989-x. [Epub ahead of print]

Pavlova GA, Popova JV, Andreyeva EN, Yarinich LA, Lebedev MO, Razuvaeva AV, Dubatolova TD, Oshchepkova AL, Pellacani C, Somma MP, Pindyurin AV, Gatti M. 2019,
RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis.
PLoS Genet. 15: e1008371.

Pavlova GA, Razuvaeva AV, Popova JV, Andreyeva EN, Yarinich LA, Lebedev MO, Pellacani C, Bonaccorsi S, Somma MP, Gatti M, Pindyurin AV. 2019.
The role of Patronin in Drosophila mitosis.
BMC Mol Cell Biol. 20 (Suppl 1):7. doi:10.1186/s12860-019-0189-0.

Pisciottani A, Biancolillo L, Ferrara M, Valente D, Sardina F, Monteonofrio L, Camerini S, Crescenzi M, Soddu S, Rinaldo C. 2019.
HIPK2 phosphorylates the microtubule-severing enzyme Spastin at S268 for abscission.
Cells 8(7). pii: E684.

Willan J, Cleasby AJ, Flores-Rodriguez N, Stefani F, Rinaldo C, Pisciottani A, Grant E, Woodman P, Bryant HE, Ciani B. 2019.
ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage.
Oncogenesis 8(5):29.

Doria F, Salvati E, Pompili L, Pirota V, D'Angelo C, Manoli F, Nadai M, Richter SN, Biroccio A, Manet I, Freccero M. 2019.
Dyads of G-quadruplex ligands triggering DNA damage response and tumour cell growth inhibition at subnanomolar concentration.
Chemistry 25:11085-97.

Traversi, Gianandrea; Staid, David Sasah; Fiore, Mario; Percario, Zulema; Trisciuoglio, Daniela; Antonioletti, Roberto; Morea, Veronica; Degrassi, Francesca; Cozzi, Renata.
A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting gamma-tubulin.
Cell division (London)

De Mori R, Severino M, Mancardi MM, Anello D, Tardivo S, Biagini T, Capra V, Casella A, Cereda C, Copeland BR, Gagliardi S, Gamucci A, Ginevrino M, Illi B, Lorefice E, Musaev D, Stanley V, Micalizzi A, Gleeson JG, Mazza T, Rossi A, Valente EM.
Agenesis of the putamen and globus pallidus caused by recessive mutations in the homeobox gene GSX2.
Brain (Online)

Scarabino D, Peconi M, Pelliccia F, Corbo RM.
Analysis of the Association Between TERC and TERT Genetic Variation and Leukocyte Telomere Length and Human Lifespan-A Follow-Up Study.
Genes (Basel)

Petrosino, Maria; Pasquo, Alessandra; Novak, Leonore; Toto, Angelo; Gianni, Stefano; Mantuano, Elide; Veneziano, Liana; Minicozzi, Velia; Pastore, Annalisa; Puglisi, Rita; Capriotti, Emidio; Chiaraluce, Roberta; Consalvi, Valerio.
Characterization of human frataxin missense variants in cancer tissues.
Human mutation: 1400-1413

Montemiglio, Linda Celeste; Testi, Claudia; Ceci, Pierpaolo; Falvo, Elisabetta; Pitea, Martina; Savino, Carmelinda; Arcovito, Alessandro; Peruzzi, Giovanna; Baiocco, Paola; Mancia, Filippo; Boffi, Alberto; des Georges, Amedee; Vallone, Beatrice.
Cryo-EM structure of the human ferritin-transferrin receptor 1 complex.
Nature communications

Montanari A, Leo M, De Luca V, Filetici P, Francisci S.
Gcn5 histone acetyltransferase is present in the mitoplasts.
Biology open: 1-9

Malagrinò, Francesca; Zuhra, Karim; Mascolo, Ludovica; Mastronicola, Daniela; Vicente, João B.; Forte, Elena; Giuffrè, Alessandro.
Hydrogen sulfide oxidation: Adaptive changes in mitochondria of SW480 colorectal cancer cells upon exposure to hypoxia.
Oxidative medicine and cellular longevity (Online)8102936

Fantechi, Elvira; Innocenti, Claudia; Ferretti, Anna Maria; Falvo, Elisabetta; Ceci, Pierpaolo; Pineider, Francesco; Sangregorio, Claudio.
Increasing the Magnetic Anisotropy of a Natural System: Co-Doped Magnetite Mineralized in Ferritin Shells.
Journal of nanoscience and nanotechnology (Print): 4964-4973

Micaela Caserta1, Tal D. Ben-Soussan 2, Valerio Vetriani3, Sabrina Venditti3 and Loredana Verdone1.
Influence of Quadrato Motor Training on Salivary proNGF and proBDNF.
Frontiers in neuroscience (Print)

Nardella C, Boi D, di Salvo ML, Barile A, Stetefeld J, Tramonti A, Contestabile R.
Isolation of a Complex Formed Between Acinetobacter baumannii HemA and HemL, Key Enzymes of Tetrapyrroles Biosynthesis.
Frontiers in Molecular Biosciences

Mocavini I, Pippa S, Licursi V, Paci P, Trisciuoglio D, Mannironi C, Presutti C, Negri R.
JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer.
Cancer science

Scarabino D (1), Veneziano L (2), Peconi M (3), Frontali M (2), Mantuano E (2), Corbo RM (4).
Leukocyte telomere shortening in Huntington's disease.
Journal of the neurological sciences: 25-29

Ardiccioni, Chiara; Arcovito, Alessandro; Della Longa, Stefano; van der Linden, Peter; Bourgeois, Dominique; Weik, Martin; Montemiglio, Linda Celeste; Savino, Carmelinda; Avella, Giovanna; Exertier, Cecile; Carpentier, Philippe; Prange, Thierry; Brunori, Maurizio; Colloc'h, Nathalie; Vallone, Beatrice.
Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments.
IUCrJ: 832-842

Laneve, Pietro; Rea, Jessica; Caffarelli, Elisa.
Long Noncoding RNAs: Emerging Players in Medulloblastoma.
Frontiers in Pediatrics

Zuhra, Karim; Tome, Catarina S.; Masi, Letizia; Giardina, Giorgio; Paulini, Giulia; Malagrino, Francesca; Forte, Elena; Vicente, Joao B.; Giuffre, Alessandro.
N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells.
Cells828

Exertier, Cecile; Milazzo, Lisa; Freda, Ida; Montemiglio, Linda Celeste; Scaglione, Antonella; Cerutti, Gabriele; Parisi, Giacomo; Anselmi, Massimiliano; Smulevich, Giulietta; Savinos, Carmelinda; Vallone, Beatrice.
Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating.
Scientific reports (Nature Publishing Group)

Zuhra, Karim; Sousa, Pedro M.F.; Paulini, Giulia; Lemos, Ana Rita; Kalme, Zenta; Bisenieks, Imants; Bisenieks, Egils; Vigante, Brigita; Duburs, Gunars; Bandeiras, Tiago M.; Bandeiras, Tiago M.; Saso, Luciano; Giuffrè, Alessandro; Vicente, João B.
Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods.
Scientific reports (Nature Publishing Group)684

Parisi, Giacomo; Montemiglio, Linda Celeste; Giuffrè, Alessandro; Macone, Alberto; Scaglione, Antonella; Cerutti, Gabriele; Exertier, Cécile; Savino, Carmelinda; Vallone, Beatrice;.
Substrate-induced conformational change in cytochrome P450 OleP.
The FASEB journal: 1787-1800

Mascolo, Elisa; Barile, Anna; Mecarelli, Lorenzo Stufera; Amoroso, Noemi; Merigliano, Chiara; Massimi, Arianna; Saggio, Isabella; Hansen, Torben; Tramonti, Angela; Di Salvo, Martino Luigi; Barbetti, Fabrizio; Contestabile, Roberto; Verni, Fiammetta.
The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity.
Scientific reports (Nature Publishing Group)

Guiducci G, Paone A, Tramonti A, Giardina G, Rinaldo S, Bouzidi A, Magnifico MC, Marani M, Menendez JA, Fatica A, Macone A, Armaos A, Tartaglia GG, Contestabile R, Paiardini A, Cutruzzolà F.
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.
nucleic acid research

Loria, Rossella; Giliberti, Claudia; Bedini, Angelico; Palomba, Raffaele; Caracciolo, Giulio; Ceci, Pierpaolo; Falvo, Elisabetta; Marconi, Raffaella; Falcioni, Rita; Bossi, Gianluca; Strigari, Lidia.
Very low intensity ultrasounds as a new strategy to improve selective delivery of nanoparticles-complexes in cancer cells.
Journal of experimental & clinical cancer research (Online)

The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells.
Favia A, Salvatori L, Nanni S, Iwamoto-Stohl LK, Valente S, Mai A, Scagnoli F, Fontanella RA, Totta P, Nasi S, Illi B.
Sci Rep. 2019 Nov 4;9(1):15925. doi: 10.1038/s41598-019-52291-6.

Targeting Endothelin-1 Receptor/ß-Arrestin-1 Axis in Ovarian Cancer: From Basic Research to a Therapeutic Approach.
Front Endocrinol (Lausanne) 2019.

ß-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer
Tocci P, et al. Nat Commun 2019 (no affiliation IBPM).Tocci P, et al.

Sechi S.; Frappaolo A.; Karimpour-Ghahnavieh A.; Gottardo M.; Burla R.; Francesco L.D.; Szafer-Glusman E.; Schinina E.; Fuller M.T.; Saggio I.; Riparbelli M.G.; Callaini G.; Giansanti M.G.
Drosophila Doublefault protein coordinates multiple events during male meiosis by controlling mRNA translation.
Development (Camb.)