My group is interested in neurodegenerative disorders caused by loss of motor neurons. Recently Drosophila melanogaster, which probably represents one of the most easily genetically manipulatable model organisms, has emerged as a valuable model system in the study of neurodegeneration. In particular, flies carrying mutations in genes essential for motor neuron survival show a reduced life span and defective locomotive behaviors. |
1. Lee SE, Kim Y, Han JK, Park H, Lee U, Na M, Jeong S, Chung C, Cestra G* and Chang S. “nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology” Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6749-54.. Epub 2016 May 25. 2. Di Salvio M, Piccinni V, Gerbino V, Mantoni F, Camerini S, Lenzi J, Rosa A, Chellini L, Loreni F, Carrì M T, Bozzoni I, Cozzolino M and Cestra G.“Pur-alpha functionally interacts with FUS carrying ALS-associated mutations” (2015) Cell Death Dis. 2015 Oct 22;6 3. Rossi S, Serrano A, Gerbino V, Giorgi A, Di Francesco L, Nencini M, Bozzo F, Schininà ME, Bagni C, Cestra G, Carrì MT, Achsel T, Cozzolino M. “Nuclear accumulation of mRNAs underlies G4C2-repeat-induced translational repression in a cellular model of C9orf72 ALS”. J Cell Sci. 2015 May 1;128(9):1787-99 4. Guan XL, Cestra G, Shui G, Kuhrs A, Schittenhelm RB, Hafen E, van der Goot FG, Robinett CC, Gatti M, Gonzalez-Gaitan M, Wenk MR. “Biochemical membrane lipidomics during Drosophila development” (20013) Dev Cell. 14;24(1):98-111. Epub 2012 Dec 20. 5. Morciano P, Carrisi C, Capobianco L, Mannini L, Burgio G, Cestra G, De Benedetto GE, Corona DF, Musio A, Cenci G. “A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity” (2009) Hum Mol Genet 18(21):4180-8. Epub 2009 Aug 4. 6. Tosoni D and Cestra G. “CAP (Cbl Associated Protein) regulates receptor mediated endocytosis” (2009) FEBS Letters 583(2):293-300. 7. Cestra G, Kwiatkowski A, Salazar M, Gertler F and De Camilli P. “Tuba, a GEF for Cdc42, links dynamin to actin regulatory proteins” (2005) Methods in Enzymology 404, 537-45. 8. Gong LW, Di Paolo G, Diaz E, Cestra G, Diaz ME, Lindau M, De Camilli P and Toomre D. “Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion” (2005) PNAS 102(14):5204-9. 9. Cestra G, Toomre D., Chang S and De Camilli P. “The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton” (2005) PNAS 102(5):1731-6. 10. Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman K, Sondek J, Gertler FB, and De Camilli P. “Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton” (2003) Journal of Biological Chemistry 278, 49031-43. |
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