• Istituto di Biologia e Patologia Molecolari


Tel :06 4991 2994-2556
Fax :06 4991 2964
antonella.palena@uniroma1.it
ANTONELLA Palena
Research Technician

'Genetica' c.o DEPT. OF BIOLOGY AND BIOTECHNOLOGY 'Charles Darwin'
campus SAPIENZA University of Rome
p.le Aldo Moro, 5 - 00185 Roma - Italy

Bucciarelli E, Pellacani C, Naim V, Palena A, Gatti M, Somma MP. Drosophila Dgt6 interacts with Ndc80, Msps/XMAP215, and gamma-tubulin to promote kinetochore-driven MT formation. Curr Biol. 2009 Nov 17;19(21):1839-45

 

Somma M.P., Ceprani F., Bucciarelli E., Naim V., De Arcangelis V., Piergentili R., Palena A., Ciapponi L., Giansanti M.G., Pellacani C., Petrucci R., Cenci G., Vernì F., Fasulo B., Goldberg M.L., Di Cunto F., Gatti M. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. PLoS Genet. Jul 18;4(7):e1000126, (2008).

 

Tritarelli A, Oricchio E, Ciciarello M, Mangiacasale R, Palena A, Lavia P, Soddu S, Cundari E. p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation. Mol Biol Cell. 2004 Aug; 15(8):3751-7.

 

Di Fiore B, Ciciarello M, Mangiacasale R, Palena A, Tassin AM, Cundari E, Lavia P. Mammalian RanBP1 regulates centrosome cohesion during mitosis. J Cell Sci. 2003 Aug 15;116(Pt 16):3399-411. Erratum in: J Cell Sci. 2003 Sep 1;116(Pt 17):3659

 

De Luca A, Mangiacasale R, Severino A, Malquori L, Baldi A, Palena A, Mileo AM, Lavia P, Paggi MG. E1A deregulates the centrosome cycle in a Ran GTPase-dependent manner. Cancer Res. 2003 Mar 15;63(6):1430-7.

 

Palena A, Mangiacasale R, Magnano AR, Barberi L, Giordano R, Spadafora C, Lavia P. E2F transcription factors are differentially expressed in murine gametes and early embryos. Mech Dev. 2000 Oct; 97(1-2):211-5.

 

Di Fiore B, Palena A, Felsani A, Palitti F, Caruso M, Lavia P. Cytosine methylation transforms an E2F site in the retinoblastoma gene promoter into a binding site for the general repressor methylcytosine-binding protein 2 (MeCP2). Nucleic Acids Res. 1999 Jul 15;27(14):2852-9.

 

Di Fiore B, Guarguaglini G, Palena A, Kerkhoven RM, Bernards R, Lavia P. Two E2F sites control growth-regulated and cell cycle-regulated transcription of the Htf9-a/RanBP1 gene through functionally distinct mechanisms. J Biol Chem. 1999 Apr 9;274(15):10339-48.

 

Battistoni A, Guarguaglini G, Degrassi F, Pittoggi C, Palena A, Di Matteo G, Pisano C, Cundari E, Lavia P. Deregulated expression of the RanBP1 gene alters cell cycle progression in murine fibroblasts. J Cell Sci. 1997 Oct; 110 ( Pt 19):2345-57.

 

Kosteas T, Palena A, Anagnou NP. Molecular cloning of the breakpoints of the hereditary persistence of fetal hemoglobin type-6 (HPFH-6) deletion and sequence analysis of the novel juxtaposed region from the 3' end of the beta-globin gene cluster. Hum Genet. 1997 Sep; 100(3-4):441-5.

 

Ciminelli BM, Pompei F, Malaspina P, Hammer M, Persichetti F, Pignatti PF, Palena A, Anagnou NP, Guanti G, Jodice C, et al. Recurrent simple tandem repeat mutations during human Y-chromosome radiation in Caucasian subpopulations. J Mol Evol. 1995 Dec; 41(6):966-73.

 

Palena A, Blau A, Stamatoyannopoulos G, Anagnou NP. Eastern European (delta-beta) zero-thalassemia: molecular characterization of a novel 9.1-kb deletion resulting in high levels of fetal hemoglobin in the adult. Blood. 1994 Jun 15;83(12):3738-45.

 

Frontali M, Malaspina P, Rossi C, Jacopini AG, Vivona G, Pergola MS, Palena A, Novelletto A. Epidemiological and linkage studies on Huntington's disease in Italy. Hum Genet. 1990 Jul;85(2):165-70.

CURRENT POSITION

Research technician  - Technical assistant  to research activities of  the group led by Dr. Patrizia Somma.

Main research activities - molecular and cellular biology approaches  to  investigate eukaryotic cell division, in  particular mitosis, using the fruitfly Drosohila melanogaster as model system.

Different  experimental procedures  (PCR, dsRNA synthesis, insects and mammalian cell cultures, RNA interference,  IF preparations)  to deeply study and analize  functions and behaviours of different proteins involved in mitotic process: spindle assembly, cytokinesis, chromosome segregation.

 

Partecipation to IBPM secretarial work, i.e. management of  human resources by:  

-      setting up all the procedures for  temporary posistions at  the Institute: drafting of public calls and attending  their whole progress;

-      being responsible for IBPM staff attendance registration and management service; monthly updating to the Central Staff Office through the informatic system

 

SHORT CV

Education and positions:

1987                   Degree in Biological Sciences (110/110), University of Naples "Federico II".

1987 - 1988      Post - laurea training at Dept. of Genetics, General and Molecular Biology, University of Naples "Federico II".

1988 - 1989   Fellowship funded by Italian Association Huntington Corea Research at Biology Dept., II University of Rome Tor Vergata.

1989 - 1990    CNR fellowship at Cybernetics Institute (Cellular Systems section) - National Research Council - Arco Felice, Naples.

1990 - 1996   Post- doctoral fellowship at Department of Basic Sciences, University of Crete School of Medicine, Heraklion, Greece

1997 - 2002    Temporary position as research technician at Evolutionary Genetics Center Rome - National Research Council c/o Dr. Lavia lab

2003 - 2010   Partecipation as lab technician to reasearch activities of Prof. Gatti and Dr. Somma group; official temporary position as administration officer at the newborn Institute of Molecular Biology and Pathology;

2010 - 2012      permanent position as administration officer at the Institute of Molecular Biology and Pathology;

2013 - present   permanent position as research technician at the Institute of Molecular Biology and Pathology, c/o Dr. Patrizia Somma laboratory