• Istituto di Biologia e Patologia Molecolari

Tel :+390644340632
Fax :+390644340632
Full Professor

Sapienza University of Rome
Department of Molecular Medicine
Viale Regina Elena, 291, Roma 00161

Over the last 20 years, the main interests of Prof. Santoni have been focused on understanding several aspects of NK cell biology. In particular she has been involved in studying the role of the intracellular signaling pathways triggered by several surface activation/adhesion receptors in NK cell functions, first demonstrating that integrins function as signaling receptors in NK cells. More recently she has been interested in analyzing the molecular mechanisms regulating the expression of NK cell activating receptor ligands on both normal and neoplastic cells. She has first proposed that NK cells may represent an immunosurveillance mechanism eliminating senescent cells.


1Ardolino M, Zingoni A, Cerboni C, Cecere F, Soriani A, Iannitto ML, Santoni A. DNAM-1 ligand expression on Ag-stimulated T lymphocytes is mediated by ROS- dependent activation of DNA-damage response: relevance for NK-T cell interaction. Blood. 2011;117:4778-86. 


2Sciumè G, De Angelis G, Benigni G, Ponzetta A, Morrone S, Santoni A, Bernardini G. CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow. Blood. 2011;117: 4467-75.


3Stabile H, Carlino C, Mazza C, Giliani S, Morrone S, Notarangelo LD, Notarangelo LD, Santoni A, Gismondi A. Impaired NK-cell migration in WAS/XLT patients: role of Cdc42/WASp pathway in the control of chemokine-induced beta integrin high-affinity state. Blood. 2010;115:2818-26.


4Fionda C, Soriani A, Malgarini G, Iannitto ML, Santoni A, Cippitelli M. Heat shock protein-90 inhibitors increase MHC class I-related chain A and B ligandexpression on multiple myeloma cells and their ability to trigger NK cell  degranulation. J Immunol. 2009;183:4385-94.


5Cerboni C, Ardolino M, Santoni A, Zingoni A. Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells. Blood. 2009;113:2955-64.


6Soriani A, Zingoni A, Cerboni C, Iannitto ML, Ricciardi MR, Di Gialleonardo V, Cippitelli M, Fionda C, Petrucci MT, Guarini A, Foà R, Santoni A. ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple  Myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood. 2009 ;113:3503-11.


7Parretta E, Cassese G, Santoni A, Guardiola J, Vecchio A, Di Rosa F. Kinetics of in vivo proliferation and death of memory and naive CD8 T cells: parameter estimation based on 5-bromo-2'-deoxyuridine incorporation in spleen, lymph nodes, and bone marrow. J Immunol. 2008;180:7230-9.


8Bernardini G, Scium‚àö¬Æ G, Bosisio D, Morrone S, Sozzani S, Santoni A.CCL3 and CXCL12 regulate trafficking of mouse bone marrow NK cell subsets.  Blood. 2008;111:3626-34.


9Cassese G, Parretta E, Pisapia L, Santoni A, Guardiola J, Di Rosa F. Bone marrow CD8 cells down-modulate membrane IL-7Ralpha expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment. Blood. 2007;110:1960-9.


10Cerboni C, Zingoni A, Cippitelli M, Piccoli M, Frati L, Santoni A. Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis. Blood. 2007;110:606-15.


Occupation or position held

since 1993 Coordinator of Ph.D. Program in Immunology, from 2011 named Immunological, Haematological and Rheumatologic Sciences, “Sapienza” University of Rome

Since 2010 Head of the Department of Molecular Medicine – “Sapienza” University of Rome

since 2009 Scientific Director of the Pasteur Institute, Cenci Bolognetti Foundation, Rome

since 2009 Member of the Patent Committee, “Sapienza” University of Rome

since 2006 Coordinator of PhD program in Molecular Biology and Medicine, “Sapienza” University of Rome

since 2005 Member of AIRC Advisory Board

since 2003 Vice President of Master Program in Medical Biotechnologies, “Sapienza” University of Rome

since 2003 Head of Molecular Pathology section, IBPM CNR Institute, Rome

since 2001 Principal Investigator of the Centre of Excellence “Molecular Biology. and Medicine” (BEMM) “Sapienza” University of Rome

Educational activity

since 1989 Full Professor, Chair of Immunology and Immunopathology, SSD MED/04, Medical School, “Sapienza” University of Rome.

Main activities and responsabilities (last 5 years)

2011-2013 Member of ERC Starting grant Committee Panel Infection and Immunity

2011-2010 Member of Grant Committee PRIN – Ministry of University and Research (MIUR) -

2011-1993 Head of Ph.D. Course of Immunology, “Sapienza” University of Rome

Since 2007 Member of the National Research Committee of Health Ministry

2009-1994 Member, Scientific Council "Istituto Pasteur - Fondazione Cenci Bolognetti", “Sapienza” University of Rome

2007-2004 Member of EMBO Long Term Fellowship Committee


Author of more than 250 publications in highly qualified international journals.