• Istituto di Biologia e Patologia Molecolari

The Institute of Molecular Biology and Pathology (IBPM) develops research in fundamental biology, with biotechnological applications in biomedicine, the environment and agrifood using interdisciplinary and multidisciplinary approaches.

IBPM laboratories are hosted within Sapienza University of Rome




 

100th ANNIVERSARY OF THE CNR FOUNDATION
https://centenario.cnr.it

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EVENTS
 
 
 
 
 
 
 
 
 
MISSION    The IBPM develops research in the following areas
  • Structural bases of protein and nucleic acid function, particularly in regulation of the expression of genes and genomes, of structural and regulatory proteins, and of molecules involved in the immune response;
  • Molecular mechanisms of evolution and differentiation in animal and plants and biotechnological and biomedical applications;
  • Design, synthesis, biosynthesis, purification and characterization of biologically active molecules: development of innovative chemical and molecular methods; characterization of their mechanisms of action; implications in human health.
 
 
IBPM HIGHLIGHTS
 
 
APRIL 16, 2025

The CNR Structural Biology Network
 

 
 
EXHIBITION

Vaccination, a time machine
Royal Society Summer Exhibition 2024, Londra
Francesca Di Rosa
 
 
RESEARCH AWARDS

EuroSPG4 Project on YouTube
The project “Spastin recovery as a new therapeutic approach for Hereditary Spastic Paraplegia (HSP)” selected for the fundraising campaign of Euro-HSP, the European Federation of HSP patients

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Tom Wahlig Foundation for spastic hereditary paraplegy
Francesca Sardina

DSB-CNR awards to starting scientists
Eugenia D'Atanasio
Anna Frappaolo

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RECENT PUBLICATIONS

The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts
Ilenia Masi et al. Journal of Experimental & Clinical Cancer Research 2025

The genomic portrait of the Picene culture provides new insights into the Italic Iron Age and the legacy of the Roman Empire in Central Italy.
Ravasini F et al. Genome Biol. 2024 Nov 21; doi: 10.1186/s13059-024-03430-4

Using art and history to communicate immunology to a broad audience
Francesca Di Rosa, Nat Rev Immunol 2024
https://rdcu.be/dT5KH

Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1.
Spizzichino S, et al. Mol Cell. 2024

Cytoplasmic accumulation of a splice variant of hnRNPA2/B1 contributes to FUS-associated toxicity in a mouse model of ALS.
Rossi S, Milani M, Della Valle I, Bisegna S, Durante V, Addesse M, D'Avorio E, Di Salvio M, Serafino A, Cestra G, Apolloni S, D'Ambrosi N, Cozzolino M. Cell Death Dis. 2025 Mar 29;16(1):219. doi: 10.1038/s41419-025-07538-8.

An antisense-long-noncoding-RNA modulates p75NTR expression levels during neuronal polarization.
De Paolis V, Paolillo N, Siri T, Grosso A, Lorello V, Spina C, Caporali G, La Regina F, Vignoli B, Giorgi C. iScience. 2024 Dec 10;28(1):111566. doi: 10.1016/j.isci.2024.111566.