• Istituto di Biologia e Patologia Molecolari

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Sapienza University of Rome
Istitute of Molecular Biology and Pathology CNR
Dipartimento di Biologia e Biotecnologie ex Edificio di Genetica - P.le A.Moro 5 00185 Roma
My research in Drosophila and human cells, is focused on understanding the mechanisms that control the mitosis to prevent the onset and maintenance of cancers.
Specifically, I’m studying the mitotic role of  many moonlighting proteins.
C. Pellacani*, E. Bucciarelli*, F. Renda, D. Hayward, A. Palena, J. Chen, S. Bonaccorsi, J. G. Wakefield, M. Gatti, M. P. Somma. 2016. Splicing Factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation. (*equal contribution)
Elife, 26;7. pii: e40325. doi: 10.7554/eLife.40325 (ISSN 2050-084X). 
Renda F, Pellacani C, Strunov A, Bucciarelli E, Naim V, Bosso G, Kiseleva E, Bonaccorsi S, Sharp DJ, Khodjakov A, Gatti M, Somma MP.2017. The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure.
PLoS Genetics, 13(5):e1006784. doi: 10.1371/journal.pgen.1006784.(ISSN 1553-7390)
Palumbo V, Pellacani C, Heesom KJ, Rogala KB, Deane CM, Mottier-Pavie V, Gatti M, Bonaccorsi S, Wakefield JG. 2015. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex. 
Current Biology, 13: 1777-83. (ISSN 0960-9822)
D. Hayward, J. Metz, C. Pellacani, J. G. Wakefield. 2014. Synergy between multiple microtubule generating pathways confers robustness to Centrosome-Driven Mitotic Spindle Formation. 
Developmental Cell, 28: 81-93.(ISSN 15345807)
Kim MY, Bucciarelli E, Morton DG, Williams BC, Blake-Hodek K, Pellacani C, Von Stetina JR, Hu X, Somma MP, Drummond-Barbosa D, Goldberg ML. 2012. Bypassing the Greatwall-Endosulfine Pathway: Variable Requirements for a Pivotal Cell Cycle Regulatory Module in Drosophila melanogaster and Caenorhabditis elegans. 
Genetics, 191: 1181-97. (ISSN 00166731, 19432631)
M. Gatti; E. Bucciarelli; R. Lattao; C. Pellacani; V. Mottier-Pavie; M.G. Giansanti; M.P. Somma; S. Bonaccorsi. 2012. The relative roles of centrosomal and kinetochore-driven microtubules in Drosophila spindle formation. 
Experimental Cell Research, 318: 1375-80. (ISSN 10902422, 00144827)
D'Angiolella V., Donato V., Jeong Y., Forester F., Kudo, Y., Pellacani C., Saraf A., Florens L., Washburn M., Pagano M. 2012. The Cyclin F-Ribonucleotide Reductase M2 axis controls genome stability and DNA repair. 
Cell, 149: 1023-34. (ISSN 10974172, 00928674)
Bucciarelli E.*, Pellacani C.*, Naim V., Palena A., Gatti M., Somma M.P. 2009. Drosophila Dgt6 interacts with Ndc80, Msps/XMAP215 and gamma-tubulin to promote kinetochore-driven MT formation. 
Current Biology, 19: 1839-45. (ISSN  0960-9822)
(*equal contribution) 
Somma, M.P., F. Ceprani, E. Bucciarelli, V. Naim, V. De Arcangelis, R. Piergentili, A. Palena, L. Ciapponi, M.G. Giansanti, C. Pellacani, R. Petrucci, G. Cenci, F. Verni, B. Fasulo, M.L. Goldberg, F. Di Cunto, and M. Gatti. 2008. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference.  
PLoS Genetics. 4: e1000126. (ISSN 1544-9173,1545-7885)
Maria Patrizia Somma
Elisabetta Bucciarelli
Maurizio Gatti, Dip. Biologia e Biotechnologie “Charles Darwin”, Sapienza
Laura Ciapponi, Dip. Biologia e Biotechnologie “Charles Darwin”, Sapienza
Silvia Bonaccorsi, Dip. Biologia e Biotechnologie “Charles Darwin”, Sapienza
Michael L. Goldberg, Dept. of Molecular Biology & Genetics, Cornell University
Ithaca, NY, USA
James G. Wakefield, Associate Professor of Integrative Cellular Biology
University of Exeter, Exeter, UK
2005 - 2009 - Ph.D, Genetica e Biologia Cellulare, University of Tuscia, Viterbo 
2004 – Achievement of the license to practice as Biologist, University of Roma “La Sapienza”, Italy 
2004 – Master’s Degree in Biological Sciences , University of Roma “La Sapienza”, Italy 110/110 Summa cum Laude 
2016-present  Contract Researcher at IBPM, CNR. 
2015-16 Post-doc Research fellow, Sapienza. 
2014-15 Post-doc Research fellow, Sapienza. 
2013-14 Post-doc fellows Ist. Pasteur. 
2012-13 Post-doc Research fellow, Sapienza. 
2012 Post-doc fellow, Ist. Pasteur. 
2011-12 Visiting post-doc fellow, NYU, NY, USA (Prof. M. Pagano). 
2010-11 Post-doc Research fellow, Sapienza. 
2009-10 Post-doc Research fellow, Sapienza. 
2004-05 Pre-doc fellows, Ist. Pasteur.