Antitumor effects of type I IFN in HPV-transformed cells. IFN-induced genes, cell cycle progression, apoptosis and senescence studies. MicroRNA profiling in mucosal or cutaneous HPV-induced tumorigenesis

Studies of signal transduction pathways in monocyte-machrophages treated with Nef of HIV.

Education/Training

- 1973-1978 Degree in Chemistry with 110/110, School of Chemistry, University of Naples, Italy,

- 1975-1978 Internal Student, Institute of Biochemistry, School of Medicine and Surgery, University of Naples, Italy

Post-doctoral training

-1978/1981 Fellowship Institute of Biochemistry, School of Medicine and Surgery, University of Naples

-1981/1982 Fellowship Laboratory of Virology, Istituto Superiore di Sanità, Rome, 

-1982/1990 Fellowship Consiglio Nazionale delle Ricerche, Rome

Employment and Experience

-From 4/6/2010 up to date, Associate Professor MED-04 General Pathology - Department of Medical-Surgical Sciences and Biotechnologies; from 1/1/2005 to 3/6/2010 Associate Professor MED-04 General Pathology - Department of Experimental Medicine, Sapienza University of Rome, Italy

-Past position: Technologist of Consiglio Nazionale delle Ricerche, Institute of Biomedical Technologies, Rome - from 09/1990 to 02/2003 and Institute of Molecular Biology and Pathology, Rome -from 02/2003 to 12/2004

-From 1981 to 2003: Guest Scientist of Laboratory of Virology, Istituto Superiore di Sanità. From 2003 to date: Guest Scientist of Department of Infectious, Parasitic and Immuno-mediate Diseases, Istituto Superiore di Sanità, Rome, Italy.

-From 1/1/2005 to date: Associate professor to the Institute of Molecular Biology and Pathology,Consiglio Nazionale delle Ricerche, Rome

Teaching activities

- Biochemistry, School of Biotechnology,  Sapienza University, Rome (from 1997/1998 to 2004/2005)

- Immunology , School of Medicine and Surgery (now School of Pharmacy and Medicine)- Degree in Medicine and Surgery, Sapienza University of Rome (2003-04 to date)

- General Pathology, School of Nursing, Technics of Biomedical Laboratory, Dental Hygiene, 2002-03 to date

- Scientific Coordinator of PhD in Innovative Technologies in Traslational Medicine, Department of Medical-Surgical Sciences and Biotechnologies, School of Pharmacy and Medicine(2011-12),

- President of Corso di Laurea Magistrale in Scienze Infermieristiche ed ostetriche B, Lazio Sud - School of Pharmacy and Medicine, Sapienza University of Rome (2011-12)

Professional Societies:

-International Society for Interferon and Cytokine Research

-European Society of Virology

-Italian Society of Immunology and Allergology

-Italian Society of Virology

Editorial Board member of Current Medicinal Chemistry (Impact Factor: 5.207), Bentham Science Publishers Ltd

Editorial board member of World International Journal of Translational Medicine (Impact Factor: 3.51) Bio Med Central Ltd

-Principal Investigator in CNR and Ministero Salute projects (i.e. Applicazioni cliniche della ricerca oncologica (1992-1996) CNR; CNR-Agenzia 2000; Progetto di ricerca finalizzata 2002-03 Ministero  Salute: ”Strategie di immunoterapia contro genotipi di HPV oncogeni e non oncogeni”).

-Co-applicant in various AIRC, AIDS and MIUR projects from 1981 to date.

-National Coordinator of MIUR, PRIN 2005 "Development of new therapeutic strategies against human herpesvirus and papilloma virus infections and their diseases"

-National Coordinator of MIUR, PRIN 2008 "Studies on the molecular mechanisms of Human Papilloma Viruses infection and associated diseases”

- Principal Investigator of Research Projects Sapienza,, Ateneo Federato, Ricerche Universitarie a.a. 2005-2011

Author of 80 peer-reviewed publications