• Istituto di Biologia e Patologia Molecolari

Tel :0649910548
Fax :
Linda Celeste Montemiglio

Istitute of Molecular Biology and Pathology - National Research Council
Department of Biochemical Sciences -A. Rossi Fanelli.
Sapienza University of Rome - Edificio di Chimica Biologica Piano terra, stanza T4 P.le A. Moro 5 - 00185 Roma

My scientific activity is focused on the structural and functional characterization of proteins involved in biological processes crucial for the development of cancer and those involved in the biosynthesis of antibiotics endowed with potential biotechnological applications. I also study how to engineer proteins to produce smart nano-vehicles for selective drug delivery for nanomedicine application. The goal of my research is identifying potential drug targets, drug makers and drug delivery proteins and defining their biomolecular profile to understand how they work and how to control their functions, using a transversal and multidisciplinary approach encompassing molecular biology, biochemistry, biophysics, structural biology and bioinformatics.

Ardiccioni C, Arcovito A, Della Longa S, van der Linden P, Bourgeois D, Weik M, Montemiglio LC, Savino C, Avella G, Exertier C, Carpentier P, Prangé T, Brunori M, Colloc’h N, Vallone B (2019) Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments. IUCrJ, 6(5), 1-11, 2019 Sept, ISSN 2052-2525; doi: 10.1107/S2052252519008157.

Testi C, Boffi A, Montemiglio LC (2019) Structural analysis of the transferrin receptor multifaceted ligand(s) interface. Biophys Chem, 254, 106242, 2019 Aug 1, ISSN 0301-4622; doi: 10.1016/j.bpc.2019.106242. 

Exertier C, Milazzo L, Freda I, Montemiglio LC, Scaglione A, Cerutti G, Parisi G, Anselmi M, Smulevich G, Savino C, Vallone B (2019) Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating. Sci Rep, 9(1), 5326, 2019 Mar 29, ISSN 2045-2322; doi: 10.1038/s41598-019-41780-3.

*Montemiglio LC, *Testi C, Ceci P, Falvo E, Pitea M, Savino C, Arcovito A, Peruzzi G, Baiocco P, Mancia F, Boffi A, des Georges A, Vallone B (2019) Cryo-EM structure of the human ferritin–transferrin receptor 1 complex. Nat Commun, 10(1), 1121, 2019 Mar 8, ISSN 2041-1723; doi: 10.1038/s41467-019-09098-w.

*Parisi G, *Montemiglio LC, Scaglione A, Sciara G, Savino C, Vallone B (2019) Substrate-induced conformational changes in the cytochrome P450 OleP. FASEBJ, 33(2):1787-1800, 2019 Feb, ISSN 1530-6860; doi: 10.1096/fj.201800450RR.

Calisti L, Trabuco MC, Boffi A, Testi C, Montemiglio LC, des Georges A, Benni I, Ilari A, Taciak B, Białasek M, Rygiel T, Król M, Baiocco P, Bonamore A (2018) Engineered ferritin for lanthanide binding. PLoS One, 13(8), e0201859, 2018 Aug 13, ISSN 1932-6203; doi: 10.1371/journal.pone.0201859.

Ferrante C, Batignani G, Fumero G, Pontecorvo E, Virga A, Montemiglio LC, Cerullo G, Vos MH, Scopigno T (2018) Resonant broadband stimulated Raman scattering in myoglobin. J Raman Spectrosc, 49(6), 913-920, 2018 Jun, ISSN 0377-0486; doi: org/10.1002/jrs.5323. 

Scaglione A, Monteonofrio L, Parisi G, Cecchetti C, Siepi F, Rinaldo C, Giorgi A, Verzili D, Zamparelli C, Savino C, Soddu S, Vallone B, Montemiglio LC (2018) Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain. Protein Sci, 27(3), 725-737, 2018 Mar, ISSN 1469-896X; doi: 10.1002/pro.3367.

Colloc'h N, Carpentier P, Montemiglio LC, Vallone B, Prangé T (2017) Mapping Hydrophobic Tunnels and Cavities in Neuroglobin with Noble Gas under Pressure. Biophys J, 113(10), 2199-2206, 2017 Nov 21, ISSN 0006-3495; doi: 10.1016/j.bpj.2017.10.014.

Scaglione A, Fullone MR, Montemiglio LC, Parisi G, Zamparelli C, Vallone B, Savino C, Grgurina I (2017) Structure of the adenylation domain Thr1 involved in the biosynthesis of 4-chlorothreonine in Streptomyces sp. OH-5093: protein flexibility and molecular bases of substrate specificity. FEBS J, 284(18), 2981-2999, 2017 Sept, ISSN 1742-4658; doi: 10.1016/j.biopen.2017.03.003.

*Scaglione A, *Montemiglio LC, *Parisi G, Asteriti IA, Bruni R, Cerutti G, Testi C, Savino C, Mancia F, Lavia P, Vallone B (2017) Subcellular localization of the five members of the human steroid 5α-reductase family. Biochimie Open, 4, 99-106, 2017 Jun, ISSN 2214-0085; doi: 10.1111/febs.14163.

de Turris V, Cardoso Trabuco M, Peruzzi G, Boffi A, Testi C, Vallone B, Montemiglio LC, Georges AD, Calisti L, Benni I, Bonamore A, Baiocco P. (2017) Humanized archaeal ferritin as a tool for cell targeted delivery. Nanoscale, 9(2), 647-655, 2017 Jan 5, ISSN 1742-4658; doi: 10.1039/c6nr07129e.

*Montemiglio LC, *Parisi G, Scaglione A, Sciara G, Savino C, Vallone B (2016) Functional analysis and crystallographic structure of clotrimazole bound OleP, a cytochrome P450 epoxidase from Streptomyces antibioticus involved in oleandomycin biosynthesis. Biochim Biophys Acta, 1860(3),465-475, 2016 Mar, ISSN 0304-4165; doi: 10.1016/j.bbagen.2015.10.009.

Barteri M, De Carolis R, Marinelli F, Tomassetti G, Montemiglio LC (2016) Effects of microwaves (900 MHz) on peroxidase systems: a comparison between lactoperoxidase and horseradish peroxidase. Electromagn Biol Med, 35(2), 126-33, ISSN 1536-8378; doi: 10.3109/15368378.2014.1002135.

- Lucia D'Auria, undergraduate student
- Andrea Mangullo, postgraduate student
- Elena Gugole, PhD student
- Ida Freda, PhD student
- Dr Gabriele Cerutti, Post Doc
- Dr Cécile Exertier, Post Doc
- Dr Carmelinda Savino, CNR-IBPM Researcher
- Prof Beatrice Vallone, University of Rome Sapienza