My research activity is mainly focused on the study of the genetic determinants of aging and human longevity, by following two specular lines of research. On the one hand, investigate susceptibility genes for age-related complex neurodegenerative diseases, in particular Alzheimer's disease (AD) and Mild Cgnitive Impairment (MCI)., which prevent the achievement of advanced ages. On the other, to investigate which genes, interacting with some non-genetic factors, can predispose to longevity,i.e. to reach the extreme ages (90-100 years). Telomere shortening has been associated with aging of organisms, in humans the length of telomeres, is measured most often in leukocytes (Leukocyte Telomere Lengths LTL), is inversely proportional to age. More recently, I investigated the relationship between LTL and AD development, including in the analysis patients with MCI, a clinical entity considered prodromal of AD. Clarifying this relationship, could help define biomarkers useful for measuring progression of the disease, with applications in clinical practice. In fact, the possibility of detecting and following the disease before the onset of the most serious symptoms, could provide a window of opportunity for actions aimed at preventing or delaying the disease. |
1. Scarabino D., Gambina G., Broggio E., Corbo R.M Leukocyte telomere length in mild cognitive impairment and Alzheimer’s disease patients. Exp Gerontol. 2017 Nov;98:143-147. doi: 10.1016/j.exger.2017.08.025. Epub 2017 Aug 19.
4. Scarabino D, Gambina G, Broggio E, Pelliccia F, Corbo RM. Influence of family history of dementia in the development and progression of late-onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2016 Mar;171B(2):250-6. doi:10.1002/ajmg.b.32399.
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Within IBPM: Rosa Maria Corbo, IBPM associate, Sapienza University of Rome, Dipartimento di Biologia e Biotecnologie Charles Darwin External collaborations: Gambina G., Brogio E.,(Alzheimer's Disease Center, Department of Neuroscience, University and Hospital of Verona) Businaro R. (Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University) Maida C., Gaudio M.R. S. Giovanni –(Addolorata Hospital, Rome) Mantuano E.,Veneziano L., (CNR Institute of Translational Pharmacology (IFT))
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Education:
1986-1989: PhD Fellowship in Applied Molecular Sciences at the Scuola Normale Superiore, Pisa,Biotechnologies Programme. 1984: Degree in Biology cum Laude, Sapienza University, Rome.
2017- to date: CNR Researcher, Institute of Molecular Biology and Pathology (IBPM), Rome. 2003-2017: CNR Researcher,Institute of Cell Biology and Neurobiology (IBCN) Campus “A.Buzzati-Traverso”, Monterotondo (Rome). 1999-2002: Researcher (permanent position) ENITECNOLOGIE SpA (ENI Group) Monterotondo (Rome).
1988-1989: Visiting researcher at University of California, Berkeley (Ca, USA), (lab head: Ignatio Tinoco)
1986-1989: PhD student, Scuola Normale Superiore, Pisa (lab head: Giuseppina Barsacchi)
1985. Post-graduate training at the Center of Evolutionary Genetics, CNR, Rome
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