• Istituto di Biologia e Patologia Molecolari

Pubblicazioni 2008

Denti M. A., Incitti T., Sthandier O., Nicoletti C., De Angelis F.G., Rizzato E., Auricchio A., Musarò A. and Bozzoni I.  
Life-long benefit of AAV/antisense-mediated exon skipping in dystrophic mice,.
Human gene therapy;19: 601-608

Saladino R., V. Neri,  C. Crestini,  G. Costanzo, M. Graciotti, E. Di Mauro.  
Synthesis and Degradation of Nucleic Acid Components by Formamide and Iron Sulphur Minerals.
Journal of the American Chemical Society (Print);130: 15512-15518

Franceschini S; Ilari A; Verzili D; Zamparelli C; Antaramian A; Rueda A; Valdivia HH; Chiancone E; Colotti G.
Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor.
The FASEB journal;22: 295-306

Ciciriello F., G. Costanzo, S. Pino, C. Crestini, R. Saladino,  E. Di Mauro.  
Molecular complexity favors the evolution of ribopolymers.
Biochemistry (Easton);47: 2732-2742

Vernarecci S, Ornaghi P, Bâgu A, Cundari E, Ballario P, Filetici P.
Gcn5p plays an important role in centromere kinetochore function in budding yeast.
Molecular and cellular biology (Print);28: 988-996

Di Felice F, Chiani F, Camilloni G.
Nucleosomes represent a physical barrier for cleavage activity of DNA topoisomerase I in vivo.
Biochemical journal (Lond., 1984);409: 651-656

Cecchetti V.; Altamura M.M.; Falasca G.; Costantino P.; Cardarelli M.
Auxin Regulates Arabidopsis Anther Dehiscence, Pollen Maturation, and Filament Elongation.
The Plant cell;20: 1760-1774

Maggi S; Massidda O; Luzi G; Fadda D; Paolozzi L; Ghelardini P.
Division protein interaction web: identification of a phylogenetically conserved common interactome between Streptococcus pneumoniae and Escherichia coli.
Microbiology (N.Y.);154: 3042-3052

Grenga L; Luzi G; Paolozzi L; Ghelardini P.
The Escherichia coli FtsK functional domains involved in its interaction with its divisome protein partners.
FEMS microbiology letters;287: 163-167

Ferretti E.; De Smaele E.; Miele E.; Laneve P.; Po A.; Pelloni M.; Paganelli A.; Di Marcotullio L.; Greco A.; Caffarelli E.; Screpanti I.; Bozzoni I.; Gulino A.
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells.
EMBO journal (Print);27: 2616-2627

Pino S., F. Ciciriello, G. Costanzo, E. Di Mauro.  
Nonenzymatic RNA Ligation in Water.

Morlando M., Ballarino M., Gromak N., Pagano F., Bozzoni I. and Proudfoot N.
Primary microRNA transcripts are processed co-transcriptionally,.
Nature structural biology

Puttini S, Lekka M, Dorchies OM, Saugy D, Incitti T, Ruegg UT, Bozzoni I, Kulik AJ, and Mermod N.  
Gene-mediated restoration of normal myofiber elasticity in dystrophic muscles.
Molecular therapy (Print)

Ferretti E., De Smaele E., Po A., Di Marcotullio L., Tosi E.,. Espinola M. S., Di Rocco C., Riccardi R., Giangaspero F., Farcomeni A., Nofroni I., Laneve P., Gioia U., Caffarelli E., Bozzoni I., Screpanti I., Gulino A.
MicroRNA profiling in human medulloblastoma.
International journal of cancer (Print)

Laneve P; Gioia U; Ragno R; Altieri F; Di Franco C; Santini T; Arceci M; Bozzoni I; Caffarelli E.
The tumor marker human placental protein 11 is an endoribonuclease.
The Journal of biological chemistry (CD-ROM);283: 34712-34719

A R Ciarbelli  (1); A Ciolfi (1); S Salvucci (1); V Ruzza (1); M Possenti (2); M Carabelli (1); A Fruscalzo (1); G Sessa (1); G Morelli (2); I Ruberti (1).
The Arabidopsis Homeodomain-leucine Zipper II gene family: diversity and redundancy.
Plant molecular biology;68: 465-478

L Farina 1; A De Santis 1; S Salvucci 2; G Morelli 3; Ruberti I 2.  
Embedding mRNA stability in correlation analysis of time-series gene expression data.
PLoS computational biology;4: 1-12

MC Palumbo 1; L Farina 2; A De Santis 2; A Giuliani 3; A Colosimo 1; G Morelli 4; I Ruberti 5.  
Collective behavior in gene regulation: Post-transcriptional regulation drives temporal compartmentalization of the yeast metabolic cycle.
The FEBS journal (Print);275: 2364-2371

Safrany J., Haasz V., Mate Z., Ciolfi A., Feher B., Oravecz A., Stec A., DallmannG., Morelli G., Ulm R. and Nagy F.
Identification of a novel cis-regulatory element for UV-B-induced transcription in Arabidopsis.
Plant journal (Print);54: 402-414

Soucek L, Whitfield J, Martins C, Finch A, Murphy D, Sodir N, Karnezis A, Brown Swigart L, Nasi S. and Evan G.
Modelling Myc inhibition as a cancer therapy.
Nature (Lond.);455: 679-683

Desantis A; Onori A; Di Certo MG; Mattei E; Fanciulli M; Passananti C;  Corbi N.
Novel activation domain derived from Che-1 cofactor coupled with the artificial protein Jazz drives utrophin upregulation.
Neuromuscular disorders

Giorgi A, Mignogna G, Bellapadrona G, Gattoni M, Chiaraluce R, Consalvi V,Chiancone E, Stefanini S.
The unusual co-assembly of H- and M-chains in the ferritin molecule from the Antarctic teleosts Trematomus bernacchii and Trematomus newnesi.
Archives of biochemistry and biophysics (Print);478: 69-74

Fiorini F, Stefanini S, Valenti P, Chiancone E, De Biase D.
Transcription of the Listeria monocytogenes fri gene is growth-phase dependent and is repressed directly by Fur, the ferric uptake regulator.
Gene (Amst.);410: 113-121

Catacchio B, D'Orazio M, Battistoni A, Chiancone E.
The dimeric assembly of Photobacterium leiognathi and Salmonella typhimurium SodC1 Cu,Zn superoxide dismutases is affected differently by active site demetallation and pH: an analytical ultracentrifuge study.
Archives of biochemistry and biophysics (Print);471: 77-84

Pacello F, Ceci P, Ammendola S, Pasquali P, Chiancone E, Battistoni A.
Periplasmic Cu,Zn superoxide dismutase and cytoplasmic Dps concur in protecting Salmonella enterica serovar Typhimurium from extracellular reactive oxygen species.

Feis A, Lapini A, Catacchio B, Brogioni S, Foggi P, Chiancone E, Boffi A, Smulevich G.
Unusually strong H-bonding to the heme ligand and fast geminate recombination dynamics of the carbon monoxide complex of Bacillus subtilis truncated hemoglobin.
Biochemistry (Easton);47: 902-910

Fowler MR; Colotti G; Chiancone E; Smith GL; Fearon M.  
Sorcin modulates cardiac L-type Ca(2+) current by functional interaction with the alpha(1C) subunit in rabbits.
Experimental physiology (Print);93: 1233-1238

Giuffrè A; Moschetti T; Vallone B; Brunori M.
Is neuroglobin a signal transducer?.
IUBMB life (Print);60: 410-413

Vicente JB; Scandurra FM; Forte E; Brunori M; Sarti P; Teixeira M; Giuffrè A.
Kinetic characterization of the Escherichia coli nitric oxide reductase flavorubredoxin.
Methods in enzymology (Print);437: 47-62

Giuffrè A; Moschetti T; Vallone B; Brunori M.
Neuroglobin: enzymatic reduction and oxygen affinity.
Biochemical and biophysical research communications (Print);367: 893-898

Di Matteo A; Scandurra FM; Testa F; Forte E; Sarti P; Brunori M; Giuffrè A.  
The O2-scavenging flavodiiron protein in the human parasite Giardia intestinalis.
The Journal of biological chemistry (Print);283: 4061-4068

Ilari A, Franceschini S, Bonamore A, Arenghi F, Botta B, Macone A, Pasquo A, Bellucci L, Boffi A.  
Structural basis of enzymatic S-norcoclaurine biosynthesis.
The Journal of biological chemistry (Print);284

Ilari A, Boffi A.
Structural studies on flavohemoglobins.
Methods in enzymology (Print);436: 187-202

Ilari A; Bonamore A; Franceschini S; Fiorillo A; Boffi A; Colotti G.
The X-ray structure of N-methyltryptophan oxidase reveals the structural determinants of substrate specificity.
Proteins (Print);71: 2065-2075

Stefanelli P; Colotti G; Neri A; Salucci ML; Miccoli R; Di Leandro L; Ippoliti R.
Molecular characterization of nitrite reductase gene (aniA) and gene product in Neisseria meningitidis isolates: is aniA essential for meningococcal survival?.
IUBMB life (Print);60: 629-636

Tramonti A; De Canio M; De Biase D.
GadX/GadW-dependent regulation of the Escherichia coli acid fitness island: transcriptional control at the gadY-gadW divergent promoters and identification of four novel 42-bp GadX/GadW-specific binding sites.
Molecular microbiology (Print);70: 965-982

Parrini C, Bemporad F, Baroncelli A, Gianni S, Travaglini-Allocatelli C, Kohn JE, Ramazzotti M, Chiti F, Taddei N.
The folding process of acylphosphatase from Escherichia coli is remarkably accelerated by the presence of a disulfide bond.
Journal of Molecular Biology;379: 1107-1118

Borgia A, Gianni S, Brunori M, Travaglini-Allocatelli C.
Fast folding kinetics and stabilization of apo-cytochrome c.
FEBS letters (Print);582: 1003-1007

Ivarsson Y, Travaglini-Allocatelli C, Brunori M, Gianni S.
Folding and misfolding in a naturally occurring circularly permuted PDZ domain.

Jemth P, Johnson CM, Gianni S, Fersht AR.
Demonstration by burst-phase analysis of a robust folding intermediate in the FF domain.
Protein engineering (Print);21: 207-214

Ivarsson Y, Travaglini-Allocatelli C, Brunori M, Gianni S.
Mechanisms of protein folding.
European biophysics journal;37: 721-728

Ivarsson Y, Travaglini-Allocatelli C, Morea V, Brunori M, Gianni S.
The folding pathway of an engineered circularly permuted PDZ domain.
Protein engineering, design & selection (Print);21: 155-160

Fontana M; Giovannitti F; Pecci L.
The protective effect of hypotaurine and cysteine sulphinic acid on peroxynitrite-mediated oxidative reactions.
Free radical research;42: 320-330

Giardina G, Rinaldo S, Johnson KA, Di Matteo A, Brunori M, Cutruzzolà F.
NO sensing in Pseudomonas aeruginosa: structure of the transcriptional regulator DNR.
Journal of Molecular Biology;378: 1002-1015

Angelucci F, Miele AE, Boumis G, Dimastrogiovanni D, Brunori M, Bellelli A.
Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase.
Proteins (Print);72: 936-945

Perluigi M, Giorgi A, Blarzino C, De Marco F, Foppoli C, Di Domenico F, Butterfield DA, Schininà ME, Cini C, Coccia R.
Proteomic analysis of protein expression and specific protein oxidation in human papillomavirus transformed keratinocytes upon UVB irradiation.
Journal of Cellular and Molecular Medicine (Print)

Calosci, N., Chi, C.N., Richter, B., Camilloni, C., Engstrom, A, Eklund, L, Travaglini-Allocatelli, C., Gianni, S., Vendruscolo, M., Jemth, P.
Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins.
Proceedings of the National Academy of Sciences of the United States of America

Lacal PM; Morea V; Ruffini F; Orecchia A; Dorio AS; Failla CM; Soro S; Tentori L; Zambruno G; Graziani G; Tramontano A; D'Atri S.
Inhibition of endothelial cell migration and angiogenesis by a vascular endothelial growth factor receptor-1 derived peptide.
European journal of cancer (1990);44: 1914-1921

Villani ME; Morea V; Consalvi V; Chiaraluce R; Desiderio A; Benvenuto E; Donini M.
Humanization of a highly stable single-chain antibody by structure-based antigen-binding site grafting.
Molecular immunology;45: 2474-2485

Panetta G; Arcovito A; Morea V; Bellelli A; Miele AE.
Hb(alphaalpha,betabeta): A novel fusion construct for a dimeric, four-domain hemoglobin.
Biochimica et biophysica acta. Proteins and proteomics;1784: 1462-1470

Soro S; Orecchia A; Morbidelli L; Lacal PM; Morea V; Ballmer-Hofer K; Ruffini F; Ziche M; D'Atri S; Zambruno G; Tramontano A; Failla CM.
A proangiogenic peptide derived from vascular endothelial growth factor receptor-1 acts through alpha5beta1 integrin.
Blood;111: 3479-3488

Montanari A; Besagni C; De Luca C; Morea V; Oliva R; Tramontano A; Bolotin-Fukuhara M; Frontali L; Francisci S.
Yeast as a model of human mitochondrial tRNA base substitutions: investigation of the molecular basis of respiratory defects.
RNA (Camb., Print);14: 275-283

Rensen WM, Mangiacasale R, Ciciarello M, Lavia P.  
The GTPase Ran: regulation of cell life and potential roles in cell transformation.
Frontiers in bioscience (Print);13: 4097-4121

Torosantucci L, De Luca M, Guarguaglini G, Lavia P, Degrassi F.  
Localized RanGTP accumulation promotes microtubule nucleation at kinetochores in  somatic mammalian cells.
Molecular biology of the cell;19: 1873-1882

De Luca M, Brunetto L, Asteriti IA, Giubettini M, Lavia P, Guarguaglini G.  
Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity.
Oncogene (Basingstoke);27: 6539-6549

Decordier I, Cundari E, Kirsch-Volders M.
Mitotic checkpoints and the maintenance of the chromosome karyotype.
Mutation research. Genetic toxicology and environmental mutagenesis (Print);651: 3-13

Stagni V, di Bari MG, Cursi S, Condò I, Cencioni MT, Testi R, Lerenthal Y, Cundari E, Barilà D.
ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells.
Blood;111: 829-837

Musarò M; Ciapponi L; Fasulo B; Gatti M; Cenci G.
Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint.
Nature genetics (Print);40: 362-366

Gao S.; Giansanti MG.; Buttrick GJ.; Ramasubramanyan S.; Auton A.; Gatti M.; Wakefield JG.  
Australin: A Chromosomal Passenger Protein required specifically for Drosophila male meiosis.
The Journal of cell biology;180: 521-535

Giansanti MG.; Bucciarelli E.; Bonaccorsi S.; Gatti M.  
Drosophila Spd-2 is an essential centriole component required for PCM recruitment and astral microtubule nucleation.
Current biology;18: 303-309

M.P. Somma; F. Ceprani; E. Bucciarelli; V. Naim; V. De Arcangelis; R. Piergentili; A. Palena; L. Ciapponi; M.G. Giansanti; C. Pellacani; R. Petrucci; G. Cenci; F. Vernì; B. Fasulo; M.L. Goldberg; F. Di Cunto; M. Gatti.  
Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference.
PLOS genetics;4

Szafer-Glusman E.; Giansanti MG.; Nishihama R.; Pringle J.; Gatti M.; Fuller MT.
A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes.
Current biology;23: 1426-1431

Scacchi R, Gambina G, Moretto G, Corbo RM.
Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine.

Corbo RM; Ulizzi L; Piombo L; Scacchi R.
Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma and APOE) on human fertility.
Biogerontology (Dordrecht);9: 317-323

Scacchi R; Gambina G; Broggio E; Ruggeri M; Corbo RM.
C-338A polymorphism of the endothelin-converting enzyme (ECE-1) gene and the susceptibility to sporadic late-onset Alzheimer's disease and coronary artery disease.
Disease markers (Print);24: 175-179

Fioriti D, Mischitelli M, Di Monaco F, Di Silverio F, Petrangeli E, Russo G, Giordano A, Pietropaolo V.
Cancer stem cells in prostate adenocarcinoma: a target for new anticancer strategies.
Journal of cellular physiology (Print);216: 571-575

Petrangeli E., L. Lenti, B. Buchett1, P. Chinzari, P. Sale, L. Salvatori, L. Ravenna, E. Lococo , E. Morgante, A. Russo, L. Frati, F. Di Silverio  and  M. A. Russo.  
Lipido-Sterolic Extract of Serenoa repens (LSESr, Permixon®) treatment affects human prostate cancer cell membrane organization.
Journal of cellular physiology (Print)

Fruci D, Giacomini P, Nicotra MR, Forloni M, Fraioli R, Saveanu L, van Endert P, Natali PG.
Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues.
Journal of cellular physiology (Print);216: 742-749

Kurzik-Dumke U, Hörner M, Czaja J, Nicotra MR,.  
Progression of colorectal cancers correlates with overexpression and loss of polarization of expression of the htid-1 tumor suppressor.
International Journal of Molecular Medicine;21: 19-31

Pasquo A, Bonamore A, Franceschini S, Macone A, Boffi A, Ilari A.
Cloning, expression, crystallization and preliminary X-ray data analysis of norcoclaurine synthase from Thalictrum flavum.
Acta crystallographica. Section F;64: 281-283

Savino,C.; Miele,A.E.; Sciara,G.; Kendrew,S.G.; Vallone,B.
Cloning, epression, purification, crystallization and preliminary X-ray crystallographic analyis of C-12 Hydroxylase EryK from Saccharoplyspora erythraea.
Protein and peptide letters (Print);15: 1138-1141

Cacchiarelli D, Santoni D, Bozzoni I.
miRNAs as prime players in a combinatorial view of evolution.

M Carabelli (1); M Possenti (2); G Sessa (1); A Ciolfi (1); M Sassi (1); G Morelli (2); I Ruberti (1).  
A novel regulatory circuit underlying plant response to canopy shade.
Plant signalling & behavior (Online);3: 137-139

Ciciriello F, Costanzo G, Pino S, Di Mauro E.
Spontaneous generation revisited at the molecular level.

G. Costanzo, F. Ciciriello, S. Pino, D. Pesce, M. Graciotti, E. Di Mauro.  
Water: From the Nonenzymatic Phosphorylation of Nucleosides to the Nonenzymatic Ligation of Oligonucleotides. Orig Life Evol Biosph.

. F. Ciciriello, G. Costanzo, S. Pino,  E. Di Mauro.  
Spontaneous generation revisited at the molecular level.

Claudio Passananti; Maria Grazia Di Certo; Nicoletta Corbi, Annalisa Onori.
Nucleic acid codifying for a utrophin transcription specific regulating protein, protein codified thereby and uses thereof.

Irene Bozzoni, Elisa Caffarelli, Pietro Laneve.
Purification, cloning and biochemical characterization of XendoU, endoribonucleasic activity involved in small nuclear RNA  splicing-independent  biosynthesis in Xenopus laevis.

Di Certo MG1; Batassa EM2,3; Casella I4; Serafino A5; Floridi A6,7; Passananti C8,9; Molinari P4#; Mattei E.1,9#.  
Delayed internalization and lack of recycling in a beta2-adrenergic receptor fused to the G protein alpha-subunit.
BMC cell biology (Online);9: 56

T Bruno; S Iezzi; F De Nicola; M Di Padova; A Desantis; M Scarsella; M G Di Certo; C Leonetti; A Floridi; C Passananti; M Fanciulli.  
Che-1 activates XIAP expression in response to DNA damage.
Cell death and differentiation;15: 515-520

Buontempo S; Barbato C; Bruno T; Corbi N; Ciotti MT; Floridi A; Fanciulli M; Passananti C.
Che-1 enhances cyclin-dependent kinase 5 expression and interacts with the active kinase-complex.
NeuroReport (Oxf.);19: 531-535

Al-Lazikani B; Hill EE; Morea V.
Protein structure prediction.

Ilari A, Savino C.
Protein structure determination by x-ray crystallography.
Methods in molecular biology (Clifton N.J., Online);452: 63-87

Parretta E.; Cassese G.; Santoni A.; Guardiola J.; Vecchio A.; Di Rosa F.
Kinetics of in vivo proliferation and death of memory and naive CD8 T cells: parameter estimation based on 5-bromo-2'-deoxyuridine incorporation in spleen, lymph nodes, and bone marrow.
The journal of immunology (1950. Online);180: 7230-7239

R Iannacone (1); F Mittempergher (2); G Morelli (3); G Panio (1); A Perito (1); I Ruberti (2); G Sessa (2); F Cellini (1).  
Influence of an Arabidopsis dominant negative athb2 mutant on tomato plant development.
Acta horticulturae;789: 263-276

Colotti G; Zamparelli C; Verzili D; Ilari A; Chiancone E.
Calcium binding proteins;3: 14-17


I Ruberti (1); M Carabelli (1); M Possenti (2); G Sessa (1); A Ciolfi (1); M Sassi (1); G Morelli (2).  
Regulatory networks for the shade avoidance response.

V Forte*;  S Baima*;  M Possenti*;  B Felici**; I Ruberti***; G Morelli*.  
Identification of ACL5 as a target of HD-ZIP III transcription factors.

Mattioli, R.; Marchese, D.; D'Angeli, S.; Altamura, M.M.; Costantino, P.; Trovato, M.
Modulation of intracellular proline levels affects flowering time and inflorescence architecture in Arabidopsis.
Plant molecular biology;66: 277-288

E. Bucciarelli, C. Pellacani, V. Naim, A. Palena, M. Gatti, M. Somma.  
The Drosophila Dgt6 Protein Interacts with Msps/ XMAP215 to Promote Kinetochore-Driven MT Formation.
Molecular biology of the cell (Online);19

Pollicita M, Muscoli C, Sgura A, Biasin A, Mollace V,Tanzarella C, Del Duca C, Rodinò P, Perno CF, Scopelliti F, Aquaro.  
NAC reduces apoptosis and telomeres shortening subsequent to HIV-1 exposure in an astrocytoma cell line.