• Istituto di Biologia e Patologia Molecolari

Pubblicazioni 2023

Stereocontrolled synthesis of new iminosugar lipophilic derivatives and evaluation of biological activities.
De Angelis M, Primitivo L, Sappino C, Centrella B, Lucarini C, Lanciotti L, Petti A, Odore D, D'Annibale A, Macchi B, Stefanizzi V, Cirigliano A, Rinaldi T, Righi G, Ricelli A.
Carbohydr Res. 2023 Dec;534:108984. doi: 10.1016/j.carres.2023.108984.

Distinct mitotic functions of Nucleolar and Spindle-Associated Protein 1 (NuSAP1) are controlled by two consensus SUMOylation sites.
Damizia M, Altieri L, Costanzo V, Lavia P.
Cells. 2023 Oct 30;12(21):2545. doi:10.3390/cells12212545.

RNA-based strategies for cancer therapy: in silico design and evaluation of ASOs for targeted exon skipping.
Pacelli C, Rossi A, Milella M, Colombo T, Le Pera L.
Int J Mol Sci. 2023 Oct 3;24(19):14862. doi: 10.3390/ijms241914862.

ALFI: Cell cycle phenotype annotations of label-free time-lapse imaging data from cultured human cells.
Antonelli L, Polverino F, Albu A, Hada A, Asteriti IA, Degrassi F, Guarguaglini G, Maddalena L, Guarracino MR.
Sci Data. 2023 Oct 4;10(1):677. doi: 10.1038/s41597-023-02540-1.

Dbx2, an aging-related homeobox gene, inhibits the proliferation of adult neural progenitors. Stem Giuliani A, Licursi V, Nisi PS, Fiore M, D'Angelo S, Biagioni S, Negri R, Rugg-Gunn PJ, Cacci E, Lupo G.
Cell Rev Rep. 2023 Nov;19(8):2837-2851. doi: 10.1007/s12015-023-10600-7.

C9orf72 toxic species affect ArfGAP-1 function.
Rossi S, Di Salvio M, Balì M, De Simone A, Apolloni S, D'Ambrosi N, Arisi I, Cipressa F, Cozzolino M, Cestra G.
Cells. 2023 Aug 5;12(15):2007. doi: 10.3390/cells12152007.

Doxorubicin and other anthracyclines in cancers: activity, chemoresistance and its overcoming.
Mattioli R, Ilari A, Colotti B, Mosca L, Fazi F, Colotti G.
Mol Aspects Med. 2023 Oct;93:101205. doi: 10.1016/j.mam.2023.101205.

Circulating miRNAs as a tool for early diagnosis of endometrial cancer-implications for the fertility-sparing process: clinical, biological, and legal aspects.
Piergentili R, Gullo G, Basile G, Gulia C, Porrello A, Cucinella G, Marinelli E, Zaami S.
Int J Mol Sci. 2023 Jul 12;24(14):11356. doi: 10.3390/ijms241411356.

High incidence of AZF duplications in clan-structured Iranian populations detected through Y chromosome sequencing read depth analysis.
Hajiesmaeil M, Ravasini F, Risi F, Magnarini G, Olivieri A, D'Atanasio E, Galehdari H, Trombetta B, Cruciani F.
Sci Rep. 2023 Jul 22;13(1):11857. doi: 10.1038/s41598-023-39069-7.

Recent insight about HE4 role in ovarian cancer oncogenesis.
Anastasi E, Farina A, Granato T, Colaiacovo F, Pucci B, Tartaglione S, Angeloni A.
Int J Mol Sci. 2023 Jun 22;24(13):10479. doi: 10.3390/ijms241310479.

Sorcin promotes migration in cancer and regulates the EGF-dependent EGFR signaling pathways. Tito C, Genovese I, Giamogante F, Benedetti A, Miglietta S, Barazzuol L, Cristiano L, Iaiza A, Carolini S, De Angelis L, Masciarelli S, Nottola SA, Familiari G, Petrozza V, Lauriola M, Tamagnone L, Ilari A, Calì T, Valdivia HH, Valdivia CR, Colotti G, Fazi F.
Cell Mol Life Sci. 2023 Jul 13;80(8):202. doi: 10.1007/s00018-023-04850-4.

Reversing vemurafenib-resistance in primary melanoma cells by combined romidepsin and type I IFN treatment through blocking of tumorigenic signals and induction of immunogenic effects.
Fragale A, Stellacci E, Romagnoli G, Licursi V, Parlato S, Canini I, Remedi G, Buoncervello M, Matarrese P, Pedace L, Ascione B, Pizzi S, Tartaglia M, D'Atri S, Presutti C, Capone I, Gabriele L.
Int J Cancer. 2023 Sep 1;153(5):1080-1095. doi: 10.1002/ijc.34602.

Epigenetic therapy against cancer: toward new molecular targets and technologies.
Sousa Â, Soares CP, Chin CM, Trisciuoglio D, Valdes-Mora F.
Front Cell Dev Biol. 2023 May 24;11:1218986. doi:10.3389/fcell.2023.1218986.

How epigenetics impacts on human diseases.
Farsetti A, Illi B, Gaetano C.
Eur J Intern Med. 2023 Aug;114:15-22. doi: 10.1016/j.ejim.2023.05.036.

A gene-nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila.
Pilesi E, Angioli C, Graziani C, Parroni A, Contestabile R, Tramonti A, Vernì F.
J Cell Physiol. 2023 Jul;238(7):1558-1566. doi: 10.1002/jcp.31033.

H3 Lysine 4 methylation is required for full activation of genes involved in alpha-ketoglutarate availability in the nucleus of yeast cells after diauxic shift.
Di Nisio E, Danovska S, Condemi L, Cirigliano A, Rinaldi T, Licursi V, Negri R.
Metabolites. 2023 Mar 31;13(4):507. doi: 10.3390/metabo13040507.

Targeted protein degradation for infectious diseases: from basic biology to drug discovery.
Espinoza-Chávez RM, Salerno A, Liuzzi A, Ilari A, Milelli A, Uliassi E, Bolognesi ML.
ACS Bio Med Chem Au. 2022 Dec 15;3(1):32-45. doi: 10.1021/acsbiomedchemau.2c00063.

Investigation of the entry pathway and molecular nature of s1 receptor ligands.
Pascarella G, Antonelli L, Narzi D, Battista T, Fiorillo A, Colotti G,Guidoni L, Morea V, Ilari A.
Int J Mol Sci. 2023 Mar 28;24(7):6367. doi:10.3390/ijms24076367.

Lamotrigine rescues neuronal alterations and prevents seizure-induced memory decline in an Alzheimer's disease mouse model.
Rizzello E, Pimpinella D, Pignataro A, Titta G, Merenda E, Saviana M, Porcheddu GF, Paolantoni C, Malerba F, Giorgi C, Curia G, Middei S, Marchetti C.
Neurobiol Dis. 2023 Jun 1;181:106106. doi: 10.1016/j.nbd.2023.106106.

The multiple mitotic roles of the ASPM Orthologous proteins: insight into the etiology of ASPM-dependent microcephaly.
Razuvaeva AV, Graziadio L, Palumbo V, Pavlova GA, Popova JV, Pindyurin AV, Bonaccorsi S, Somma MP, Gatti M.
Cells. 2023 Mar 16;12(6):922. doi: 10.3390/cells12060922.

HIPK2 in the physiology of nervous system and its implications in neurological disorders.
Sardina F, Conte A, Paladino S, Pierantoni GM, Rinaldo C.
Biochim Biophys Acta Mol Cell Res. 2023 Jun;1870(5):119465. doi: 10.1016/j.bbamcr.2023.119465.

A diagnostic circulating miRNA signature as orchestrator of cell invasion via TKS4/TKS5/EFHD2 modulation in human gliomas.
Díaz Méndez AB, Sacconi A, Tremante E, Lulli V, Caprara V, Rosanò L, Goeman F, Carosi M, Di Giuliani M, Vari G, Silvani A, Pollo B, Garufi C, Ramponi S, Simonetti G, Ciusani E, Mandoj C, Scalera S, Villani V, Po A, Ferretti E, Regazzo G, Rizzo MG.
J Exp Clin Cancer Res. 2023 Mar 17;42(1):66. doi: 10.1186/s13046-023-02639-8.

The "superoncogene" Myc at the crossroad between metabolism and gene expression in glioblastoma multiforme.
Cencioni C, Scagnoli F, Spallotta F, Nasi S, Illi B.
Int J Mol Sci. 2023 Feb 20;24(4):4217. doi: 10.3390/ijms24044217.

A new insight into MYC Action: control of RNA polymerase ii methylation and transcription
termination.
Scagnoli F, Palma A, Favia A, Scuoppo C, Illi B, Nasi S.
Biomedicines. 2023 Jan 30;11(2):412. doi:10.3390/biomedicines11020412.

New cellular imaging-based method to distinguish the SPG4 subtype of hereditary spastic paraplegia.
Sardina F, Valente D, Fattorini G, Cioffi E, Zanna GD, Tessa A, Trisciuoglio D, Soddu S, Santorelli FM, Casali C, Rinaldo C.
Eur J Neurol. 2023 Jun;30(6):1734-1744. doi: 10.1111/ene.15756.

Aurora B SUMOylation is restricted to centromeres in early mitosis and requires RANBP2.
Di Cesare E, Moroni S, Bartoli J, Damizia M, Giubettini M, Koerner C, Krenn V, Musacchio A, Lavia P.
Cells. 2023 Jan 19;12(3):372. doi: 10.3390/cells12030372. .

Silver thiolate nanoclusters as support for chiral ligands: application in heterogeneous phase asymmetric catalysis.
Primitivo L, De Angelis M, Necci A, Di Pietro F, Ricelli A, Caschera D, Pilloni L, Suber L, Righi G.
Nanoscale Adv. 2022 Dec 24;5(3):627-632. doi: 10.1039/d2na00692h.

Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production.
Pellegrini FR, De Martino S, Fianco G, Ventura I, Valente D, Fiore M, Trisciuoglio D, Degrassi F.
Autophagy. 2023 Jul;19(7):2078-2093. doi: 10.1080/15548627.2023.2170962.

A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression.
Di Nisio E, Licursi V, Mannironi C, Buglioni V, Paiardini A, Robusti G, Noberini R, Bonaldi T, Negri R.
Cancer Gene Ther. 2023 Jun;30(6):822-832. doi: 10.1038/s41417-022-00584-w.

RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.
Sebastiani J, Puxeddu M, Nalli M, Bai R, Altieri L, Rovella P, Gaudio E, Trisciuoglio D, Spriano F, Lavia P, Fionda C, Masci D, Urbani A, Bigogno C, Dondio G, Hamel E, Bertoni F, Silvestri R, La Regina G.
Eur J Med Chem. 2023 Jan 15;246:114997. doi:10.1016/j.ejmech.2022.114997.

Non-transport roles of nuclear import receptors: In need of the right balance.
Damizia M, Altieri L, Lavia P.
Front Cell Dev Biol. 2022 Nov 10;10:1041938. doi: 10.3389/fcell.2022.1041938.

Disclosing complex mutational dynamics at a Y chromosome palindrome evolving through intra- and inter-chromosomal gene conversion.
Bonito M, Ravasini F, Novelletto A, D'Atanasio E, Cruciani F, Trombetta B.
Hum Mol Genet. 32: 65-78. doi: 10.1093/hmg/ddac144.