Laboratory of Genetics @ San Lorenzo Compound – Via degli Apuli 4
EDUCATION
2015 – PhD degree in Genetics and Cell biology, University of Viterbo “Tuscia”
2010 – MSc degree in Medical Biotechnology, University of Rome-2 “Tor Vergata”
2008 – BSc degree in Biotechnology, University of Rome-2 “Tor Vergata”
SCIENTIFIC POSITIONS AND RESEARCH EXPERIENCE
2019-current: CNR post-doctoral position, IBPM – Genetics lab
Project “High content imaging in validation of anti-mitotic drugs” (funded by Regione Lazio)
2016-19: FIRC postdoctoral fellow, IFO-Regina Elena National Cancer Institute, Rome.
Project: “Recruitment of HIPK2 and extrachromosomal H2B at the midbody: dissecting the molecular pathways” (funded by AIRC)
2012-15: PhD student, IFO-Regina Elena National Cancer Institute, Rome.
PhD thesis: HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity
2011-12: Post-graduate fellow, IFO-Regina Elena National Cancer Institute, Rome.
Project: Evaluation of expression and localization of HIPK2 and its mutant derivative during mitosis and cytokinesis
PUBLICATIONS
• Monteonofrio L., D. Valente*, M. Ferrara, S. Camerini, R. Miscione, M. Crescenzi, C. Rinaldo, S. Soddu. HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis. Oncogene (2018) *co-first author
• Barbiero I., D. Valente*, C. Chandola, F. Magi, A. Bergo, L. Monteonofrio, M. Tramarin, M. Fazzari, S. Soddu, N. Landsberger, C. Rinaldo, C. Kilstrup-Nielsen. CDKL5 localizes at the centrosome and midbody and is required for faithful cell division. Sci Rep (2017) *co-first author
• Pierantoni G.M., A. Conte, C. Rinaldo, M. Tornincasa, R. Gerlini, D. Valente, A. Izzo, A. Fusco. Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities. Cell cycle (2016)
• Pierantoni G.M., A. Conte, C. Rinaldo, M. Tornincasa, R. Gerlini, A. Federico, D. Valente, E. Medico, A. Fusco. Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes. Oncotarget (2015)
• Valente D., G. Bossi, A. Moncada, M. Tornincasa, S. Indelicato, S. Piscuoglio, E.D. Karamitopoulou, A. Bartolazzi, G.M. Pierantoni, A. Fusco, S. Soddu, C. Rinaldo. HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity. Oncotarget (2015)
• Battisti S., D. Valente*, L. Albonici, R. Bei, A. Modesti, C. Palumbo. Nutritional stress and arginine auxotrophy confer high sensitivity to chloroquine toxicity in mesothelioma cells. Am J Respir Cell Mol Biol (2012) *co-first author
Keywords: Cytokinesis; Chromosomal Instability; Tumorigenesis