Tel :+39 06 49917536
Fax :+39 096 4457528
davide.valente@cnr.it
Fax :+39 096 4457528
davide.valente@cnr.it
DAVIDE VALENTE
Researcher
Istitute of Molecular Biology and Pathology - National Research Council
Department of Biology and Biotecnology - Charles Darwin
Sapienza University of Rome - sede di Via degli Apuli 4 00185 Roma
Researcher
Istitute of Molecular Biology and Pathology - National Research Council
Department of Biology and Biotecnology - Charles Darwin
Sapienza University of Rome - sede di Via degli Apuli 4 00185 Roma
| As a cell biologist, my primary research area involves exploring pathways associated with tumorigenesis. Specifically, my focus is on investigating the functions of HIPK2, a protein kinase that plays a crucial role in various cellular processes, including DNA damage response, apoptosis, and differentiation. I am particularly interested in studying the contribution of HIPK2 in the initiation and progression of liver and pancreatic cancer. To achieve this, I have developed in vitro and in vivo models to study these types of tumors and I have demonstrated that HIPK2 deficiency can increase the risk of tumorigenesis by cytokinesis failure. In addition to my work on HIPK2, I am also involved in the development of image-based tests that use advanced microscopy techniques. Ongoing projects: 1. Addressing liver fibrosis prevention and treatment by targeting the pro-fibrotic kinase HIPK2 2. Development of image-based assay to evaluate: -Radio-induced DNA damage -p53 mitotic centrosomal localization |
| Sardina F., Valente D., et al. New cellular imaging-based method to distinguish the SPG4 subtype of hereditary spastic paraplegia. European Journal of Neurology, 2023 Pellegrini F.R., et al. Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production. Autophagy, 2023 Valente D., et al. Factors to Consider for the Correct Use of ?H2AX in the Evaluation of DNA Double-Strand Breaks Damage Caused by Ionizing Radiation. Cancers, 2022, 14(24), 6204 Polverino F., et al. The Aurora-A/TPX2 Axis Directs Spindle Orientation in Adherent Human Cells by Regulating NuMA and Microtubule Stability. Current Biology, 2021, 31(3), pp. 658–667.e5 Contadini C., et al. p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway. Cell Death and Disease, 2019, 10(11), 850 Monteonofrio L., Valente D. et al. Extrachromosomal histone h2b contributes to the formation of the abscission site for cell division. Cells, 2019, 8(11), 1391 Monteonofrio L., Valente D.* et al. HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis. Oncogene, 2018, 37(26), pp. 3562–3574 Barbiero I., Valente D*., et al. CDKL5 localizes at the centrosome and midbody and is required for faithful cell division. Scientific Reports, 2017, 7(1), 6228 Valente D., et al. HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity. Oncotarget, 2015, 6(12), pp. 10320–10334 Battisti S., Valente D.*, et al. Nutritional stress and arginine auxotrophy confer high sensitivity to chloroquine toxicity in mesothelioma cells. American Journal of Respiratory Cell and Molecular Biology, 2012, 46(4), pp. 498–506 *co-first author |
| within IBPM: Cinzia Rinaldo Francesca Sardina IBPM NIKON Imaging Platform Trisciuoglio Daniela with other Institutions: Silvia Soddu (Regina Elena Cancer Institute) Francesco Spallotta (Sapienza University) |
| Education - 2015: PhD in Genetics and Molecular Biology (“Tuscia” University of Viterbo) - 2010: Master’s degree in Medical Biotechnology (“Tor Vergata” University of Rome) - 2008: Bachelor’s degree in Biotechnology (“Tor Vergata” University of Rome) Work experience -November 2022-present: Research scientist at CNR - Institute of Molecular Biology and Pathology (IBPM) - April 2020-November 2022: Medical researcher at IRCCS IFO - Regina Elena National Cancer Institute - April 2019-April 2020: Postdoctoral fellow at IBPM-CNR - January 2016-April 2019: Fondazione Italiana Ricerca sul Cancro (FIRC) Post-doctoral fellow at IRCCS IFO - Regina Elena National Cancer Institute - April 2012 – May 2015: PhD student at IRCCS IFO - Regina Elena National Cancer Institute |