• Istituto di Biologia e Patologia Molecolari

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Istitute of Molecular Biology and Pathology - National Research Council
Department of Biology and Biotecnology - Charles Darwin
Sapienza University of Rome - Via degli Apuli 4 00185 Roma
My interests are focused on the study of signal transduction pathways in cancer and neurodegenerative disease. During my PhD studies and post-doc, in the laboratory headed by Prof. Daniela Barilà, I acquired a large experience on signal transduction induced by ATM kinase, a central player in DNA damage response and in maintenance of genomic stability. I contributed to characterize new roles of ATM kinase in cell death signaling pathway, in hypoxia pathway and in ubiquitin dependent pathway. Moreover in collaboration with the laboratory of Dr. Flavio Maina (IBDML, Marseille, France) I investigated the molecular mechanism involved in aberrant Receptor Tyrosine Kinase (RTKs) induced signal transduction during tumor development. From 2013 I gained my research independence at Fondazione S.Lucia in Rome supported by two grant from Italian Ministry of Health, on the role of non-canonical ATM kinase functions in breast cancer progression. From 2019 I have started my own research group at IBPM.  I’m currently investigated signal transduction pathways involved in cancer stem cell maintenance (3D culture model systems), in cancer therapies resistance and in neurodegenerative disease.

1)Mongiardi MP, Radice G, Piras M, Stagni V, Pacioni S, Re A, Putti S, Ferrè F, Farsetti A, Pallini R, Barilà D, Levi A, Falchetti ML. Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation. Oncogene. 2019 Apr 9. doi: 10.1038/s41388-019-0798-2  IF 6.854

2) Antonelli, M., Strappazzon, F., Arisi, I., Brandi, R., D'Onofrio, M., Sambucci, M., Manic, G., Vitale, I.,Barilà D., Stagni, V*. ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy(2017) Oncotarget, 8 (13), pp. 21692-21709. Cited 5 times. DOI: 10.18632/oncotarget.15537 IF 5.168

3) Stagni V.*, Manni, I., Oropallo, V., Mottolese, M., Di Benedetto, A., Piaggio, G., Falcioni, R., Giaccari, D., Di Carlo, S., Sperati, F., Cencioni, M.T., Barilà, D.ATM kinase sustains HER2 tumorigenicity in breast cancer (2015) Nature Communications, 6, art. no. 6886, . Cited 18 times.DOI: 10.1038/ncomms7886 IF 11.470 *Corresponding author

4) Santini, S., Stagni, V., Giambruno, R., Fianco, G., Di Benedetto, A., Mottolese, M., Pellegrini, M., Barilà, D.ATM kinase activity modulates ITCH E3-ubiquitin ligase activity (2014) Oncogene, 33 (9), pp. 1113-1123. Cited 14 times. DOI: 10.1038/onc.2013.52 I.F. 8.459

5) Mongiardi, M.P.*, Stagni, V.*, Natoli, M., Giaccari, D., D'Agnano, I., Falchetti, M.L., Barilà, D., Levi, A. Oxygen sensing is impaired in ATM defective cells (2011) Cell Cycle, 10 (24), pp. 4311-4320. Cited 13 times. DOI: 10.4161/cc.10.24.18663 I.F.4.565*Authors contributed equally to this work.

6) Furlan, A.*, Stagni, V.*, Hussain, A., Richelme, S., Conti, F., Prodosmo, A., Destro, A., Roncalli, M., Barilà, D., Mainá, F.Abl interconnects oncogenic Met and p53 core pathways in cancer cells. (2011) Cell Death and Differentiation, 18 (10), pp. 1608-1616. Cited 50 times.DOI: 10.1038/cdd.2011.23 16 I.F.8.184 *Authors contributed equally to this work.

7) Stagni, V., Mingardi, M., Santini, S., Giaccari, D., Barilà, D.ATM kinase activity modulates cFLIP protein levels: Potential interplay between DNA damage signalling and TRAIL-induced apoptosis (2010) Carcinogenesis, 31 (11), pp. 1956-1963. Cited 27 times. DOI: 10.1093/carcin/bgq193 I.F.5.334

8) Stagni, V., Di Bari, M.G., Cursi, S., Condò, I., Cencioni, M.T., Testi, R., Lerenthal, Y., Cundari, E.,Barilà, D.ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells (2008) Blood, 111 (2), pp. 829-837. Cited 20 times. DOI: 10.1182/blood-2007-04-085399 I.F.10.452

9) Cursi, S., Rufini, A., Stagni, V., Condò, I., Matafora, V., Bachi, A., Bonifazi, A.P., Coppola, L., Superti-Furga, G., Testi, R., Barilà, D.Src kinase phosphorylates Caspase-8 on Tyr380: A novel mechanism of apoptosis suppression (2006) EMBO Journal, 25 (9), pp. 1895-1905. Cited 139 times. DOI: 10.1038/sj.emboj.7601085 I.F. 10.434

10) Cozzolino*, M., Stagni, V.*, Spinardi, L., Campioni, N., Fiorentini, C., Salvati, E., Alemà, S., Salvatore, A.M.P120 catenin is required for growth factor-dependent cell motility and scattering in epithelial cells (2003) Molecular Biology of the Cell, 14 (5), pp. 1964-1977. Cited 68 times.DOI: 10.1091/mbc.E02-08-0469 l I.F. 4.466 *Both authors contributed equally to this work.

H index: 13 (Scopus  ID 6507949155) ORCID ID: 0000-0002-3971-0398 RESEARCH ID: K-6430-2016

Area di ricerca in cell division, genetic instability, cell death and cancer

Silvia Orecchia (master student, University of Rome “Tor Vergata”, Corso di Laurea Magistrale in Biotecnologie) collaboration with Fondazione S.Lucia Rome
- Prof. Daniela Barilà,   University of Rome “Tor Vergata”, Fondazione S.Lucia Rome.

-Prof.Claudio Sette, University of Rome “Cattolica”, Fondazione S.Lucia Rome.

-Prof. Maria Paola Paronetto, University of Rome “Foro Italico”, Fondazione S.Lucia Rome.

-Dr. Flavie Strappazzon, Fondazione S.Lucia Rome.

-Dr.Chiara Gabellini, University of Pisa.

-Dr Chiara Parisi, CNR , IBB

-Dr Manuela Pellegrini, CNR , IBB

-Dr Maria Patrizia Mongiardi, CNR, IBB

-Dr Maria Laura Falchetti, CNR, IBB

-Dr Enrico Cundari, CNR, IBPM

- 2008: PhD degree in Molecular and Cellular Biology, Tor Vergata” University of Rome, Italy
- 2003: Degree in Biological Sciences cum Laude, Sapienza University of Rome

Research positions and activity

-November 2019-present: research scientist appointment at IBPM
-January 2013-november 2019: Researcher at Fondazione S.Lucia, Rome.
-January 2010-december 2012: Post-doc Laboratory of Dr. Daniela Barilà University “Tor Vergata”, Rome, department of Biology, supported by AIRC
-January 2009-december 2009: Winner of post-doc fellowship supported by AIRC Fellowship supported by AIRC “Loredana Gualandi Sabotti fellowship for hepatoma cancer research Fondazione S.Lucia, Rome. Cell signalling unit, headed by Dr. Daniela Barilà
-December 2004-December 2008: PhD program in “Molecular and Cellular Biology”, Cycle XX coordinated by Prof.Gianni Cesareni University of Rome, Tor Vergata, tutor Dr Daniela Barilà, Dulbecco telethon institute (DTI). PhD salary supported by Telethon foundation
-December 2003-November 2004 Fellowship, Dulbecco telethon institute (DTI), University of Tor Vergata Rome, department of Experimental Medicine and Biochemical Sciences, laboratory of Dr Daniela Barilà
-January 2001-November 2003 Pre-graduate and post-graduate internship, CNR, IBCN Rome

Grant and awards:

-January 2019 – December 2021: winner of a Grant as coordinator of 1 unit of the project:”Exploiting the co- and post-transcriptional regulation of gene expression as therapeutic tool for human cancer”, coordinated by Prof. Claudio Sette and founded by Ministry of Health in Italy (2016). Fondazione S.Lucia in Rome represented the Institutional recipient of this grant. RF-2016-0236346. € 150.000 for the unit coordinated by VS (€ 432.000 total)
-January 2013-december 2017: winner of a grant, as Principal Investigator, amount:  € 322.540, 00; project code: GR-2010-2312868, Ministry of Health
-March 2014: winner of BD Biosciences summer 2014 Stem cell award cycle.
-January 2009: winner of Italian Association for Cancer Research (AIRC) one year fellowship.
-September 2004: winner of prize in the memory of the biologist “Antonio Marzullo” for   the best biological thesis 2003  

Teaching activities and Student supervision experience

-September  2018-present; “Docente Titolare”, Teaching activity course of “Nuove terapie molecolari nei tumori” (BIO-18) (2CFU),  CdL Magistrale in BIOLOGIA CELLULARE E MOLECOLARE E SCIENZE BIOMEDICHE., University Tor Vergata, Rome (since a.a. 2018/2019).
-January 2013-december 2016. PhD supervisor of Dr.ssa Martina Antonelli, “Role of ATM kinase in ErbB2 signaling: novel therapeutic target    to hit ErbB2-positive breast cancer stem cells?” PhD program in “Molecular and Cellular Biology”, coordinated by Prof.Gianni Cesareni, University of Rome “Tor Vergata” (XXIX Cycle)