• Istituto di Biologia e Patologia Molecolari

Tel :06-49255246
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Istitute of Molecular Biology and Pathology - National Research Council
EBRI - Rita Levi Montalcini Foundation
Via Regina Elena, 295, Rome, Italy
My research focuses on understanding how neurons communicate and how alterations of neuronal transmission relate to behavioral states in health and disease. Recent work is on:

·    Common alterations of hippocampal neuronal excitability in Alzheimer’s Disease (AD) and Epilepsy
·    Hippocampal synaptic transmission and plasticity in rodent models of AD and autism spectrum disorders
·    The involvement of microRNA-34 in synaptic transmission and its role in stress
  • Rizzello E, Middei S, Marchetti C Synaptic Correlates of Anterograde Amnesia and Intact Retrograde Memory in a Mouse Model of Alzheimer’s Disease. Current Alzheimer Research., 17: 259-268. doi: 10.2174/1567205017666200224122113, 2020.
  • Lupascu CA, Morabito A, Merenda E, Marinelli S, Marchetti C, Migliore R, Cherubini E, Migliore M. A General Procedure to Study Subcellular Models of Transsynaptic Signaling at Inhibitory Synapses Frontiers in Neuroinformatics, 10:23. doi: 10.3389/fninf.2016.00023, 2016.
  • Bianchi D, De Michele P, Marchetti C, Tirozzi B, Cuomo S, Marie H, Migliore M. Effects of increasing CREB-dependent transcription on the storage and recall processes in a hippocampal CA1 microcircuit. Hippocampus, Feb;24(2):165-77, 2014.
  • Romani A, Marchetti C, Bianchi D, Leinekugel X, Poirazi P, Migliore M, Marie H. Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses. Frontiers in Computational Neuroscience, 7:1. DOI: 10.3389/fncom.2013.00001, 2013
  • Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M. On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons Journal of Computational Neuroscience, 33(2): 207-25. doi: 10.1007/s10827-012-0383-y, 2012.
  • Marchetti C, Marie H. Hippocampal synaptic plasticity in Alzheimer's disease: what have we learned so far from transgenic models? Reviews in the Neurosciences; 22(4):373-402, 2011
  • Marchetti C, Tafi E, Marie H. Viral-mediated expression of a constitutively active form of cAMP response element binding protein in the dentate gyrus increases long term synaptic plasticity. 190:21-6, 2011.
  • D’Amelio M, Cavallucci V, Middei S, Marchetti C, Pacioni S, Ferri A, Diamantini A, De Zio D, Carrara P, Battistini L, Moreno S, Marie H, Bacci A, Ammassari-Teule M, and Cecconi F. Non-apoptotic caspase-3 activity triggers synaptic degeneration at the onset of Alzheimer’s Disease. Nature Neuroscience.14: 69-76, 2011.
  • Houeland G., Romani A., Marchetti C., Amato G., Capsoni S., Cattaneo A., Marie H Transgenic mice with chronic NGF deprivation and Alzheimer’s disease-like pathology, display hippocampal region-specific impairments in short- and long-term plasticities. Journal of Neuroscience, 13089-94: 69-76, 2010.
  • Marchetti C., Tafi E., Middei S., Rubinacci MA., Restivo L., Ammassari-Teule M., Marie H. Synaptic Adaptations of CA1 Pyramidal Neurons Induced by a Highly Effective Combinational Antidepressant Therapy. Biological Psychiatry. 67: 146-54, 2010.
As Group Leader at EBRI, I tutor PhD students, Master’s Degree students and post-docs.
Corinna Giorgi (IBPM-CNR and Fondazione EBRI, Rome, Italy)
Silvia Middei (IBCN-CNR, Rome, Italy)
Enrico Cherubini (Fondazione EBRI, Rome, Italy)
Diego Andolina, Luisa Loiacono (Sapienza University, Rome Italy)
Giulia Curia (Università degli Studi di Modena e Reggio Emilia)
Michele Migliore (IBF-CNR Palermo, Italy)


2020-present. CNR permanent researcher, III level.

2013-present. Group leader at EBRI “Rita Levi-Montalcini” Foundation, Rome, Italy.

2007-2012. Senior Post-doctoral Fellow, EBRI “Rita Levi-Montalcini” Foundation (Supervisor: Dr. Hélène Marie)

2005-2006. Post-doctoral Fellow, New York University (Supervisor: Prof. Alex Reyes)

2003-2004. Post-doctoral Fellow, NIH (Supervisor: Dr. Micheal O’Donovan) and Visiting Scholar, New York University (Supervisor: Prof. John Rinzel)

1998-2002. PhD student, International School for Advanced Studies (SISSA), Trieste, Italy (Supervisor: Prof. Andrea Nistri)

1998. Degree in Physics (Master’s level in Biophysics); University of Rome “La Sapienza”.

Scientific Interests and Expertise

  • Hippocampal synaptic transmission and plasticity, alterations in Alzheimer’s Disease (AD), Autism Spectrum Disorders and infantile encephalopathies.
  • Regulation of neuronal excitability and alterations in AD
  • Synaptic transmission and stress-related alterations in the Dorsal Raphe Nucleus
  • My main technical expertise is ex vivo electrophysiology. In my work, I use pharmacological and viral mediated gene transfer to manipulate protein levels and function in neurons of rodents in vivo. We also regularly perform behavioral and molecular biology experiments, as well as computational modeling, in close collaborations with other laboratories.