• Istituto di Biologia e Patologia Molecolari

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Institute of Molecular Biology and Pathology, National Research Council
Sapienza University of Rome, General Physiology Building - first floor
Piazzale Aldo Moro 5, 00185 Rome, Italy
Study of the molecular features of human neoplastic and metabolic diseases:
- identification of a DNA-binding independent transcriptional action of the estrogen receptor (ER) counteracted by retinoic acid receptor on the promoter of the EGF receptor (EGFR) gene, in cervical cancer cells;
- evaluation of EGFR transcription induced by selective ER modulators (SERMs) and the resulting effects on osteoblast differentiation;
- analysis of the role of FSH receptor, of the inflammatory/reparative phenotype, and the effects of antiandrogens in models of prostate cancer;
- evaluation of the molecular and functional features of mesenchymal stem cells isolated from adipose tissue (ASC) of non-obese and obese subjects, providing information concerning the use of ASC in regenerative medicine.
More recently, the research has focused on the study of the interactions between microenvironment and stem cells:
- evaluation of the influence of tissue inflammatory and hypoxic state on mesenchymal stem cells isolated from both subcutaneous and visceral adipose tissue of non-obese and obese individuals to identify new therapeutic strategies for obesity;
- analysis of the contribution of cancer stem cells (CSC) to prostate cancer progression, showing that context-specific microenvironmental signals control the tumorigenicity of CSC.
Currently, the effect of nitric oxide on glioblastoma stem cells (GSCs), and particularly its influence on stemness maintenance as well as GSCs differentiation, is investigated.
Sirtuins 1-7 expression in human adipose-derived stem cells from subcutaneous and visceral fat depots: influence of obesity and hypoxia.
S. Mariani, G. Di Rocco, G. Toietta, M.A. Russo, E. Petrangeli and L. Salvatori.
Endocrine, 57: 455-463, 2017.

HIF3α: the little we know.
L. Ravenna, L. Salvatori and M.A. Russo.
FEBS J, 283: 993-1003, 2016.

Hypoxia promotes the inflammatory response and stemness features in visceral fat stem cells from obese subjects.
E. Petrangeli, G. Coroniti, A.T. Brini, L. de Girolamo, D. Stanco, S. Niada, G. Silecchia, E. Morgante, C. Lubrano, M.A. Russo and L. Salvatori.
J Cell Physiol, 231: 668-679, 2016.

Distinct phenotypes of human prostate cancer cells associate with different adaptation to hypoxia and pro-inflammatory gene expression.
L. Ravenna, L. Principessa, A. Verdina, L. Salvatori, M.A. Russo and E. Petrangeli.
PLoS ONE, 9: e96250, 2014.

Stemness and osteogenic and adipogenic potential are differently impaired in subcutaneous and visceral adipose derived stem cells (ASCs) isolated from obese donors
L. de Girolamo, D. Stanco, L. Salvatori, G. Coroniti, E. Arrigoni, G. Silecchia, M.A. Russo, S. Niada, E. Petrangeli and A.T. Brini.
Int J Immunopathol Pharmacol, 26(1 Suppl): 11-21, 2013.

Cell-to-cell signaling influences the fate of prostate cancer stem cells and their potential to generate more aggressive tumors.
L. Salvatori, F. Caporuscio, A. Verdina, G. Starace, S. Crispi, M.R. Nicotra, A. Russo, R.A. Calogero, E. Morgante, P.G. Natali, M.A. Russo and E. Petrangeli.
PLoS ONE, 7: e31467, 2012.

Action of retinoic acid receptor on EGFR gene transactivation and breast cancer cell proliferation: interplay with the estrogen receptor.
L. Salvatori, L. Ravenna, F. Caporuscio, L. Principessa, G. Coroniti, L. Frati, M.A. Russo and E. Petrangeli.
Biomed Pharmacother, 65: 307-312, 2011.

Aromatase inhibitor exemestane has antiproliferative effects on human mesothelioma cells.
D. Stoppoloni, L. Salvatori, A. Biroccio, C. D'angelo, P. Muti, A. Verdina, A. Sacchi, B. Vincenzi, A. Baldi and R. Galati.
J Thorac Oncol, 6: 583-591, 2011.

Up-regulation of the inflammatory-reparative pathway in human prostate carcinoma.
L. Ravenna, P. Sale, M Di Vito, A. Russo, L. Salvatori, M. Tafani, E. Mari, S. Sentinelli, E. Petrangeli, M. Gallucci, F. Di Silverio, E. Garaci and M.A. Russo.
Prostate, 69: 1245-1255, 2009.

Down-regulation of EGF receptor induced by estrogens and phytoestrogens promotes the differentiation of human U2OS cells.
L. Salvatori, F. Caporuscio, G. Coroniti, G. Starace, L. Frati, M.A. Russo and E. Petrangeli.
J Cell Physiol, 220: 35-44, 2009.

The artificial four zinc finger protein Bagly binds human utrophin promoter A at the endogenous chromosomal site and activates transcription.
A. Onori, A. Desantis, S. Buontempo, M.G. Di Certo, M. Fanciulli, L. Salvatori, C. Passananti and N. Corbi.
Biochem Cell Biol, 85: 358-365, 2007.

Expression and cellular localization of follicle-stimulating hormone receptor in normal human prostate, benign prostatic hyperplasia and prostate cancer.
S. Mariani, L. Salvatori, S. Basciani, M. Arizzi, G. Franco, E. Petrangeli, G. Spera and L. Gnessi.
J Urology, 175: 2072-2077, 2006.

Cell death, proliferation and repair in human myocarditis responding to immunosuppressive therapy.
A. Frustaci, C. Chimenti, M. Pieroni, L. Salvatori, E. Morgante, P. Sale, E. Ferretti, E. Petrangeli, A. Gulino and M.A. Russo.
Mod Pathol, 19: 755-765, 2006.

Oestrogens and selective oestrogen receptor (ER) modulators regulate EGF receptor gene expression through human ER alpha and beta subtypes via an Sp1 site.
L. Salvatori, P. Pallante, L. Ravenna, P. Chinzari, L. Frati, M.A. Russo and E. Petrangeli.
Oncogene, 22: 4875-4881, 2003.

Identification of an estrogen-mediated deoxyribonucleic acid-binding independent transactivation pathway on the epidermal growth factor receptor gene promoter.
L. Salvatori, L. Ravenna, M.P. Felli, M.R. Cardillo, M.A. Russo, L. Frati, A. Gulino and E. Petrangeli.
Endocrinology, 141: 2266-2274, 2000.

Isolation of human type 2 deiodinase gene promoter and characterization of a functional cyclic adenosine monophosphate response element.
G. Canettieri, F.S. Celi, G. Baccheschi, L. Salvatori, M. Andreoli and M. Centanni.
Endocrinology, 141: 1804-1813, 2000.
Barbara Illi, IBPM researcher
Annarita Favia, post-doctoral fellow
Fiorella Scagnoli, PhD student
Sergio Nasi, senior researcher, IBPM associate
Within IBPM:
Barbara Illi
Elisa Caffarelli
Sergio Nasi

With other institutions:
Matteo Antonio Russo, Consorzio MEBIC, San Raffaele University, Rome, Italy
Stefania Mariani, Sapienza University of Rome, Rome, Italy
Giuliana Di Rocco, Regina Elena National Cancer Institute, Rome, Italy
Gabriele Toietta, Regina Elena National Cancer Institute, Rome, Italy
3/2003: PhD in Human Pathology, Sapienza University of Rome.
7/1993: Biology degree, Sapienza University of Rome, 110/110 cum laude.

Current position and research experience
12/2009-today: CNR Researcher, Institute of Molecular Biology and Pathology, investigating the interactions between stem cells and microenvironment.
11/2002-12/2009: Post-doctoral fellow, Sapienza University of Rome, analyzing the effects of steroid hormones in cancer and osteoporosis.
11/1998-10/2002: PhD student in Human Pathology, Sapienza University of Rome, investigating the transactivation of the EGFR promoter induced by estrogens and SERMs.
6/1997: Visiting scientist at the Prostate Research Laboratory, University of Edinburgh.
4/1995-1/1999: CNR fellow, working on the analysis of molecules involved in cancer progression.
9/1993-3/1995: Training post-degree, CNR.

Role in Ministerial Committees
2014: Member of the Scientific Secretariat of the Scientific Committee appointed by the Minister of Health to evaluate the Stamina method of Stamina Foundation.

Referee activity
2012-2014: Referee for the scientific journal PLoS ONE.

2007-2009: Teacher of Biochemistry and Clinical Biochemistry at the Degree Course in Biomedical Laboratory Techniques, Sapienza University of Rome.
1999-present: Supervisor of undergraduate and PhD students working in the laboratory.

Research grants
2002-2003: responsible for Progetto Giovani Ricercatori MURST 2002.
1996-today: participant in 15 projects funded by Ministry of Health, MIUR, pharmaceutical companies.

Papers on international journals: 28
Book chapters: 1
Citation in the acknowledgments of papers on international journals: 1
Meeting abstracts published on international journals: 6
Congress Proceedings: 2
Abstracts of congress presentations: 39
Papers on national journals: 2