ISTRUZIONE E FORMAZIONE
2021: Dottorato di ricerca in Scienze Cardio Nefro Toraciche, Università di Bologna “Alma Mater Studiorum” (33°ciclo)
2016: Laurea Magistrale in Scienze e Tecnologie Genetiche, Università del Sannio
2014: Laurea Triennale in Scienze Biologiche, Università degli Studi di Napoli Federico II
ESPERIENZA DI RICERCA
2022-to date: Assegnista di ricerca, CNR-Istituto di Biologia e Patologia Molecolari (IBPM), Roma.
Progetto: “IMPARA - IMAGING DALLE MOLECOLE ALLA PRECLINICA - PROGRAMMA MUR “PNIR - PROGRAMMA NAZIONALE INFRASTRUTTURE DI RICERCA”
2021-2022: Ricercatore aziendale livello IV S, Carebios srl -Biogem scarl, Ariano Irpino (AV)
2017-2021: Dottorando, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale dell’Università di Bologna, Bologna
Progetto di dottorato: “In vivo evaluation of renal function using intravital multiphoton microscopy on rats and mice with induced or spontaneous renal injury”
2018-2019: Dottorando “invitato”, “Department of Biomedicine, Aarhus University”, Aarhus (Danimarca)
Progetto svolto: “Characterization of ASP+ as a probe for estimation of organic cation transport in the proximal tubule by in vivo 2-photon microscopy
2015-2016: Tirocinante di tesi magistrale, Biogem scarl, Ariano Irpino (AV)
Progetto di tesi: “Characterization of novel mutations in Arginine Vasopressin Receptor 2 gene (AVPR2) causing Nephrogenic Diabetes Insipidus”
2014: Tirocinante di tesi triennale, CNR-Istituto di Biostrutture e Bioimmagini (IBB), Napoli.
Progetto di tesi: “Synthesis of oligolysines and binding studies towards nucleic acids of biomedical interest”
PUBBLICAZIONI
1. Francesco Trepiccione et al. “The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI”. Sci. Transl. Med.15, eabn4214(2023).
2. Damizia, M.; Altieri, L.; Costanzo, V.; Lavia, P. “Distinct Mitotic Functions of Nucleolar and Spindle-Associated Protein 1 (NuSAP1) Are Controlled by Two Consensus SUMOylation Sites”. Cells 2023, 12, 2545. https://doi.org/10.3390/cells12212545
3. Brogna C, Costanzo V, Brogna B, Bisaccia DR, Brogna G, Giuliano M, Montano L, Viduto V, Cristoni S, Fabrowski M, Piscopo M. “Analysis of Bacteriophage Behavior of a Human RNA Virus, SARS-CoV-2, through the Integrated Approach of Immunofluorescence Microscopy, Proteomics and D-Amino Acid Quantification”. Int J Mol Sci. 2023 Feb 15;24(4):3929.
4. Costanzo, V.; Roviello, G.N. “The Potential Role of Vaccines in Preventing Antimicrobial Resistance (AMR): An Update and Future Perspectives”. Vaccines 2023, 11, 333. https://doi.org/10.3390/vaccines11020333
5. Costanzo, V.; Costanzo, M. Correction: Costanzo, V.; Costanzo, M. “Intravital Imaging with Two-Photon Microscopy: A Look into the Kidney”. Photonics 2022, 9, 294. Photonics 2022, 9, 759. https://doi.org/10.3390/photonics9100759
6. D'Acierno M, Resaz R, Iervolino A, Nielsen R, Sardella D, Siccardi S, Costanzo V, D'Apolito L, Suzumoto Y, Segalerba D, Astigiano S, Perna AF, Capasso G, Eva A, Trepiccione F. “Dapagliflozin Prevents Kidney Glycogen Accumulation and Improves Renal Proximal Tubule Cell Functions in a Mouse Model of Glycogen Storage Disease Type 1b”. J Am Soc Nephrol. 2022 Oct;33(10):1864-1875. Epub 2022 Jul 12. PMID: 35820785; PMCID: PMC9528317.
7. Vincenzo Costanzo, Melinda Gilhen-Baker, Diana Beresford-Kroeger & Giovanni N Roviello* “Tree-inhabiting polypore fungi as sources of a cornucopia of bioactive compounds” Future Microbiol 2022 Aug:17:899-902.
8. Costanzo, V., D’Apolito, L., Sardella, D. et al. “Single nephron glomerular filtration rate measured by linescan multiphoton microscopy compared to conventional micropuncture”. Pflugers Arch - Eur J Physiol (2022). 10.1007/s00424-022-02686-8
9. Jacob Schade Engbjerg, Vincenzo Costanzo, Donato Sardella, Luca Bordoni, Steen Jakobsen, Luciano D'Apolito, Jørgen Frøkiær, Francesco Trepiccione, Giovambattista Capasso, and Sebastian Frische “The Probe for Renal Organic Cation Secretion (4-Dimethylaminostyryl)-N-Methylpyridinium (ASP+)) Shows Amplified Fluorescence by Binding to Albumin and Is Accumulated In Vivo”. Mol Imaging (2022). 10.1155/2022/7908357
10. Tianyi Shao, Henu Kumar Verma, Babita Pande, Vincenzo Costanzo, Weibing Ye, Yuyan Cai* and L. V. K. S. Bhaskar* “Physical Activity and Nutritional Influence on Immune Function: An Important Strategy to Improve Immunity and Health Status”. Front. Physiol. (2021);12:751374 10.3389/fphys.2021.751374
11. Federica Petrillo, Anna Iervolino, Tiziana Angrisano, Sabina Jelen, Vincenzo Costanzo, Mariavittoria D’Acierno, Lei Cheng, Qi Wu, Ilaria Guerriero, Maria Cristina Mazzarella, Alfonso De Falco, Fulvio D’Angelo, Michele Ceccarelli, Michele Caraglia, Giovambattista Capasso, Robert A. Fenton and Francesco Trepiccione “Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus”. J Am Soc Nephrol (2021), 32 (6) 1339-1354; 10.1681/ASN.2020010031
12. Federica Prosperi, Yoko Suzumoto, Pierluigi Marzuillo, Vincenzo Costanzo, Sabina Jelen, Anna Iervolino, Stefano Guarino, Angela La Manna, Emanuele Miraglia Del Giudice, Alessandra F. Perna, Miriam Zacchia, Emmanuelle Cordat, Giovambattista Capasso & Francesco Trepiccione* “Characterization of five novel vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus reveals a role of tolvaptan for M272R-V2R mutation”. Sci Rep. 10, 16383 (2020) 10.1038/s41598-020-73089-x
13. Roviello GN, Vicidomini C, Costanzo V, Roviello V “Nucleic acid binding and other biomedical properties of artificial oligolysines”. Int J Nanomedicine. (2016); 11: 5897–5904 10.2147/IJN.S121247
2021: Dottorato di ricerca in Scienze Cardio Nefro Toraciche, Università di Bologna “Alma Mater Studiorum” (33°ciclo)
2016: Laurea Magistrale in Scienze e Tecnologie Genetiche, Università del Sannio
2014: Laurea Triennale in Scienze Biologiche, Università degli Studi di Napoli Federico II
ESPERIENZA DI RICERCA
2022-to date: Assegnista di ricerca, CNR-Istituto di Biologia e Patologia Molecolari (IBPM), Roma.
Progetto: “IMPARA - IMAGING DALLE MOLECOLE ALLA PRECLINICA - PROGRAMMA MUR “PNIR - PROGRAMMA NAZIONALE INFRASTRUTTURE DI RICERCA”
2021-2022: Ricercatore aziendale livello IV S, Carebios srl -Biogem scarl, Ariano Irpino (AV)
2017-2021: Dottorando, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale dell’Università di Bologna, Bologna
Progetto di dottorato: “In vivo evaluation of renal function using intravital multiphoton microscopy on rats and mice with induced or spontaneous renal injury”
2018-2019: Dottorando “invitato”, “Department of Biomedicine, Aarhus University”, Aarhus (Danimarca)
Progetto svolto: “Characterization of ASP+ as a probe for estimation of organic cation transport in the proximal tubule by in vivo 2-photon microscopy
2015-2016: Tirocinante di tesi magistrale, Biogem scarl, Ariano Irpino (AV)
Progetto di tesi: “Characterization of novel mutations in Arginine Vasopressin Receptor 2 gene (AVPR2) causing Nephrogenic Diabetes Insipidus”
2014: Tirocinante di tesi triennale, CNR-Istituto di Biostrutture e Bioimmagini (IBB), Napoli.
Progetto di tesi: “Synthesis of oligolysines and binding studies towards nucleic acids of biomedical interest”
PUBBLICAZIONI
1. Francesco Trepiccione et al. “The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI”. Sci. Transl. Med.15, eabn4214(2023).
2. Damizia, M.; Altieri, L.; Costanzo, V.; Lavia, P. “Distinct Mitotic Functions of Nucleolar and Spindle-Associated Protein 1 (NuSAP1) Are Controlled by Two Consensus SUMOylation Sites”. Cells 2023, 12, 2545. https://doi.org/10.3390/cells12212545
3. Brogna C, Costanzo V, Brogna B, Bisaccia DR, Brogna G, Giuliano M, Montano L, Viduto V, Cristoni S, Fabrowski M, Piscopo M. “Analysis of Bacteriophage Behavior of a Human RNA Virus, SARS-CoV-2, through the Integrated Approach of Immunofluorescence Microscopy, Proteomics and D-Amino Acid Quantification”. Int J Mol Sci. 2023 Feb 15;24(4):3929.
4. Costanzo, V.; Roviello, G.N. “The Potential Role of Vaccines in Preventing Antimicrobial Resistance (AMR): An Update and Future Perspectives”. Vaccines 2023, 11, 333. https://doi.org/10.3390/vaccines11020333
5. Costanzo, V.; Costanzo, M. Correction: Costanzo, V.; Costanzo, M. “Intravital Imaging with Two-Photon Microscopy: A Look into the Kidney”. Photonics 2022, 9, 294. Photonics 2022, 9, 759. https://doi.org/10.3390/photonics9100759
6. D'Acierno M, Resaz R, Iervolino A, Nielsen R, Sardella D, Siccardi S, Costanzo V, D'Apolito L, Suzumoto Y, Segalerba D, Astigiano S, Perna AF, Capasso G, Eva A, Trepiccione F. “Dapagliflozin Prevents Kidney Glycogen Accumulation and Improves Renal Proximal Tubule Cell Functions in a Mouse Model of Glycogen Storage Disease Type 1b”. J Am Soc Nephrol. 2022 Oct;33(10):1864-1875. Epub 2022 Jul 12. PMID: 35820785; PMCID: PMC9528317.
7. Vincenzo Costanzo, Melinda Gilhen-Baker, Diana Beresford-Kroeger & Giovanni N Roviello* “Tree-inhabiting polypore fungi as sources of a cornucopia of bioactive compounds” Future Microbiol 2022 Aug:17:899-902.
8. Costanzo, V., D’Apolito, L., Sardella, D. et al. “Single nephron glomerular filtration rate measured by linescan multiphoton microscopy compared to conventional micropuncture”. Pflugers Arch - Eur J Physiol (2022). 10.1007/s00424-022-02686-8
9. Jacob Schade Engbjerg, Vincenzo Costanzo, Donato Sardella, Luca Bordoni, Steen Jakobsen, Luciano D'Apolito, Jørgen Frøkiær, Francesco Trepiccione, Giovambattista Capasso, and Sebastian Frische “The Probe for Renal Organic Cation Secretion (4-Dimethylaminostyryl)-N-Methylpyridinium (ASP+)) Shows Amplified Fluorescence by Binding to Albumin and Is Accumulated In Vivo”. Mol Imaging (2022). 10.1155/2022/7908357
10. Tianyi Shao, Henu Kumar Verma, Babita Pande, Vincenzo Costanzo, Weibing Ye, Yuyan Cai* and L. V. K. S. Bhaskar* “Physical Activity and Nutritional Influence on Immune Function: An Important Strategy to Improve Immunity and Health Status”. Front. Physiol. (2021);12:751374 10.3389/fphys.2021.751374
11. Federica Petrillo, Anna Iervolino, Tiziana Angrisano, Sabina Jelen, Vincenzo Costanzo, Mariavittoria D’Acierno, Lei Cheng, Qi Wu, Ilaria Guerriero, Maria Cristina Mazzarella, Alfonso De Falco, Fulvio D’Angelo, Michele Ceccarelli, Michele Caraglia, Giovambattista Capasso, Robert A. Fenton and Francesco Trepiccione “Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus”. J Am Soc Nephrol (2021), 32 (6) 1339-1354; 10.1681/ASN.2020010031
12. Federica Prosperi, Yoko Suzumoto, Pierluigi Marzuillo, Vincenzo Costanzo, Sabina Jelen, Anna Iervolino, Stefano Guarino, Angela La Manna, Emanuele Miraglia Del Giudice, Alessandra F. Perna, Miriam Zacchia, Emmanuelle Cordat, Giovambattista Capasso & Francesco Trepiccione* “Characterization of five novel vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus reveals a role of tolvaptan for M272R-V2R mutation”. Sci Rep. 10, 16383 (2020) 10.1038/s41598-020-73089-x
13. Roviello GN, Vicidomini C, Costanzo V, Roviello V “Nucleic acid binding and other biomedical properties of artificial oligolysines”. Int J Nanomedicine. (2016); 11: 5897–5904 10.2147/IJN.S121247