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The Institute of Molecular Biology and Pathology (IBPM) was born from the merging of three CNR Research Centres within the "Sapienza" University of Rome, the Centre for Molecular Biology Studies (CSBM), founded by Prof. Alessandro Rossi Fanelli in 1965, The Centre for Evolutionary Genetics Studies (CSGE) that began its activities in 1969 under the direction of Prof. Giuseppe Montalenti and the Centre for Studies on Nucleic Acids (CSAN), founded in 1970 by Prof. Giorgio Tecce who has been its ispirational Director for over twenty years.  Research groups active in translational research also  joined the IBPM-CNR from the Institute of Biomedical Technology (ITBM) to form the laboratory of Molecular Pathology.  More recently, researchers in Biomolecular Chemistry, also located at Sapienza University, joined IBPM and formed the laboratory of chemistry. 
The Institute's main task is to address issues in biology with a multidisciplinary approach based on theoretical and experimental biochemistry, molecular biology, genetics and molecular pathology. The initiative, launched in 2003, has been ahead of the development of modern biology, characterized by a growing interdisciplinary, thematic and methodological flexibility.
Presently, the scientific network of the IBPM-CNR includes four research laboratories, five CNR Main Research Projects, and an Administrative Section.
The main research topics of the Institute can be summarized as follows:
a) Study of the mechanisms of control of gene expression in animals and plants.
b) Multidisciplinary study of molecular and cellular basis of cancer: development of diagnostic and prognostic biomarkers, nanoparticles and new strategies for targeted therapy of human tumors.
c) Identification of the tissue-specific role of non-coding RNAs in development and cell differentiation and identification of methods for tissue-specific targeting.
d) Structural biology: structure and function, dynamics and recognition in proteins.
In recent years, new scenarios have opened for "Modern Biology" allowing it to  face major challenges in knowledge with a broad and deep impact not only within Human Health, but also in the areas of Food, Environment, Energy and Nanotechnology.
Our Institute pursues the study of biological phenomena with multidisciplinary approaches and translational objectives. Researchers working in the Institute are aware that knowledge of the basic mechanisms of life is not only a value in itself, but that it is also endowed with several applications in biotechnology and biomedicine. We are guided by the principle that, in order to progress and be competitive, it is essential to implement and enhance basic research, which is the foundation for applied research and technological innovation.

The mission of the IBPM Institute is to investigate the molecular mechanisms underlying fundamental biological processes (including cell division, proliferation, differentiation and death; development and senescence; stress response; immune response), using multidisciplinary approaches that integrate biochemistry, molecular and cellular biology, genetics, bioinformatics and chemistry. Gaining molecular understanding of these processes enables translational applications in biotechnology and biomedicine.