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Prof.ssa Clara Balsano
 Clara Balsano

Via Palestro 32 - 00185 Roma

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Telefono: +39 06 49933094/3874


 

RESEARCH INTERESTS

Prof. Balsano’s group focused its experimental/research’s interests in the following research areas:
a) fatty liver disease and cardiovascular risk; b) hepatic manifestation of the metabolic syndrome with or without of hepatitis C virus infection; c) study of the role of microbiota in the etiopathogenesis of metabolic syndrome and obesity; d) etiopathogenesis of hepatocarcinoma and its molecular characterization; e) molecular mechanisms of HCV infection; f) immune response to hepatic viruses infection g) diagnostic and clinical aspects of chronic hepatitis B and C; h) interaction between Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV-1); i) prognostic factors of chronic HCV infection response to interferon treatment; l) signal transduction induced by IFN-alpha and metabolism  arachidonic acid (aa) metabolism; m) aetiopathogenetic mechanisms and therapy of chronic autoimmune hepatitis.

CURRICULUM VITAE

In 1987 graduated as a medical doctor at the University of Rome “La Sapienza”. From 1989 to 1992 get a research fellowship to work at the laboratory of "Biochimie Genetique" at the Hopital Cochin-Paris, direct by Dr. Pascale Briand.
Associate Professor of Internal Medicine at the University of L’Aquila (Italy), since 1992.
Head of Clinical and Biomolecular Hepatology Unit at the University of L’Aquila, Department of Internal Medicine, since 1993. Head of the laboratory of “Viral and Molecular Oncology” at the Andrea Cesalpino Foundation, since 2003. Head of the laboratory “Pathology of Development”, IRCCS SR-La Pisana, since 2005. Full Professor of Internal Medicine and Chair of Clinical Hepatology Unit at the University of L’Aquila, since 2007. From 2008 Director of Urgency and Emergency Medicine Specialty. Detached to the Ministry of Research, in 2009, to collaborate for the laboratories reconstruction, after the earthquake of the 6 April of the same year. In the same period participated in writing the National Research Program. From 2010 Scientific expert for Italian Ministry of Research for the evaluation of projects of National Operative Program – PON.

SCIENTIFIC PRODUCTION: 

Author of more than 100 scientific papers. Citations > 3500 (WOS); IF > 560; H-index: 30 (WOS); G-index: 60 (WOS)

REVIEWERS FOR THE FOLLOWING JOURNALS: 

Hepatology; J. of Hepatology; Digestive and Liver Disease; Oncogene. PNAS; PLOSone; Italian Journal of Internal Medicine; Virology; J. of Virology; Nutrition; 

EDITOR IN CHIEF OF:

- WORLD JOURNAL OF HEPATOLOGY (WJH) 
- INTERNATIONAL JOURNAL OF VIROLOGY AND AIDS 


ASSOCIATE EDITOR: 

- TUMOR BIOLOGY

 GRANTS

MIUR ex 60% grants years: 1994 - 1995 - 1996 - 1997 - 1998 - 1999 - 2000 - 2001 - 2002 - 2003 - 2004 - 2005 - 2006 - 2007 - 2008 - 2009 - 2010 - 2011 - 2012.
CNR grant (n. 97.03997.CT04) for a project entitled: “ Molecular characterization of potential transformation of core and NS3 proteins of Hepatitis C virus.
MIUR ex 40% grant (DM 23/3/1997) for a project entitled: “Viral and genetic factors in the molecular pathogenesis of the hepatocarcinoma”, year 1998.
CEE grant reference n. QLK2-CT-200200954, year 2002.
FIRB grant n.RBNE013PMJ_007 (D.R. n. 3 del 27-11-2002).
PRIN grant (D.M. 51/2010/Ric) for the project entitled “Intestinal microflora, steatosis and chronic liver damage”, year 2009.
AIRC n. 12936 for the project entitled: “Role of focal adhesion kinase as master regulator of fibrogenesis and metastasis in hepatocellular carcinoma”, in the 2003.
Gilead Awards - 2014 - "The nuclear receptor" small heterodimer partner ": a new potential marker for a targeted therapy in the course of hepatitis C virus infection"
Umberto Veronesi Foundation - 2014 - A normocaloric low cholesterol diet  regulates  Th17 / Treg  balance in hepatitis C chronically infected patients.

MEMBERSHIPS IN PROFESSIONAL AND SCIENTIFIC SOCIETIES:

European Medicines Agency (EMA) 
Italian Society of Gastroenterology (SIGE) 
European Association for the Study of the Liver (EASL) 
American Association for the Study of the Liver Diseases (AASLD) 
Italian Society of Internal Medicine (SIMI) 
Medical Accademy of Rome 
Italian Society of Biophysics and Molecular Biology (SIBBM) 
Science’s Accademy 
American Society for Biochemistry and Molecular Biology (ASBMB) 
Italian Association Study on Liver (AISF) 

TEACHING ACTIVITIES

From 1993/1994 to the 2011/2012 academic years taught at the following Degree Courses:
- Medicine and Surgery;
- Dentistry and Dental Implants;
- Nursing;
- Biotecnologies.
and in the following Postgraduate Schools:
- Internal Medicine;
- Gastroenterology;
- Cardiology;
- Clinical Allergology and Immunology;
- Clinical Pathology.
Teaching at 2nd level Master Degree, named “Nutrition and Health”. 
In the academic years 2008-2010 Prof. Balsano directed and taught at the Urgency and Emergency Specialty.



SELECTED PUBLICATIONS

- Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.
Gnani D, Romito I, Artuso S, Chierici M, De Stefanis C, Panera N, Crudele A, Ceccarelli S, Carcarino E, D'Oria V, Porru M, Giorda E, Ferrari K, Miele L, Villa E, Balsano C, Pasini D, Furlanello C, Locatelli F, Nobili V, Rota R, Leonetti C, Alisi A.
Cell Death Differ. 2017 Mar 24. doi: 10.1038/cdd.2017.34. [Epub ahead of print] - PMID: 28338656

- Small heterodimer partner 1 directly interacts with NS5A viral protein and has a key role in HCV related liver cell transformation.

Conti B, Porcu C, Viscomi C, Minutolo A, Costantini S, Corazzari M, Iannucci G, Barbaro B, Balsano C.
Oncotarget. 2016 Sep 20. doi: 10.18632/oncotarget.12144. 

- AISF position paper on liver transplantation and pregnancy: Women in Hepatology Group, Italian Association for the Study of the Liver (AISF).
Women in Hepatology Group; Italian Association for the Study of the Liver (AISF).
Dig Liver Dis. 2016 Aug;48(8):860-8. doi: 10.1016/j.dld.2016.04.009. Epub 2016 May 20

- Core domain mutant Y220C of p53 protein has a key role in copper homeostasis in case of free fatty acids overload.
Arciello M, Longo A, Viscomi C, Capo C, Angeloni A, Rossi L, Balsano C.
Biometals. 2015 Dec;28(6):1017-29. doi: 10.1007/s10534-015-9886-0. Epub 2015 Oct 5.

- Protective Effect of the Y220C Mutant p53 Against Steatosis: Good News?
Gori M, Barbaro B, Arciello M, Maggio R, Viscomi C, Longo A, Balsano C.
J Cell Physiol. 2015 Jun;230(6):1400. doi: 10.1002/jcp.24874. 

- Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infection.
Maggio R, Viscomi C, Andreozzi P, D'Ettorre G, Viscogliosi G, Barbaro B, Gori M, Vullo V, Balsano C.
PLoS One. 2014 Dec 22;9(12):e112346. doi: 10.1371/journal.pone.0112346. eCollection 2014.

- Effects of the olive-derived polyphenol oleuropein on human health.
Barbaro B, Toietta G, Maggio R, Arciello M, Tarocchi M, Galli A, Balsano C.
Int J Mol Sci. 2014 Oct 14;15(10):18508-24. doi: 10.3390/ijms151018508. 

- Could monitoring normotensives delay progression to hypertension?
Iannucci G, Scarpellini E, Balsano C, Paroli M, Leone G, Giannoni MF.
Eur Rev Med Pharmacol Sci. 2014 Jun;18(11):1680-1. 

- Plasma high mobility group box 1 protein reflects fibrosis in pediatric nonalcoholic fatty liver disease.
Alisi A, Nobili V, Ceccarelli S, Panera N, De Stefanis C, De Vito R, Vitali R, Bedogni G, Balsano C, Cucchiara S, Stronati L.
Expert Rev Mol Diagn. 2014 Jul;14(6):763-71. doi: 10.1586/14737159.2014.928205. Epub 2014 Jun 13.

- MicroRNAs in nonalcoholic fatty liver disease: novel biomarkers and prognostic tools during the transition from steatosis to hepatocarcinoma.
Gori M, Arciello M, Balsano C.
Biomed Res Int. 2014;2014:741465. doi: 10.1155/2014/741465. Epub 2014 Mar 13. 

- Lymphocytes as liver damage mirror of HCV related adipogenesis deregulation.
Minutolo A, Conti B, Grelli S, Viscomi C, Labbadia G, Balsano C.
PLoS One. 2014 Mar 21;9(3):e92343. doi: 10.1371/journal.pone.0092343. eCollection 2014.

- Breath tests for the assessment of the orocecal transit time.
Scarpellini E, Abenavoli L, Balsano C, Gabrielli M, Luzza F, Tack J.
Eur Rev Med Pharmacol Sci. 2013;17 Suppl 2:39-44. 

- Protective effect of the Y220C mutant p53 against steatosis: good news?
Gori M, Barbaro B, Arciello M, Maggio R, Viscomi C, Longo A, Balsano C.
J Cell Physiol. 2014 Sep;229(9):1182-92. doi: 10.1002/jcp.24550. Erratum in: J Cell Physiol. 2015 Jun;230(6):1400. J Cell Physiol. 2015 Jun;230(6):1400

- Mitochondrial dysfunctions and altered metals homeostasis: new weapons to counteract HCV-related oxidative stress.
Arciello M, Gori M, Balsano C.
Oxid Med Cell Longev. 2013;2013:971024. doi: 10.1155/2013/971024. Epub 2013 Nov 24. 

- Office normotensives with a minimal augmentation of intima-media thickness of common carotid arteries: really normotensives?
Iannucci G, Balsano C, Paroli M, Scarpellini E, Leone G, Giannoni MF.
Eur Rev Med Pharmacol Sci. 2013 Dec;17(23):3164-8.

- Environmental pollution: a tangible risk for NAFLD pathogenesis.
Arciello M, Gori M, Maggio R, Barbaro B, Tarocchi M, Galli A, Balsano C.
Int J Mol Sci. 2013 Nov 7;14(11):22052-66. doi: 10.3390/ijms141122052.

- Probiotics in non-alcoholic fatty liver disease: which and when. L. Abenavoli, E. Scarpellini, S. Rouabhia, C. Balsano, F. Luzza. Ann Hepatol, 12(3): 357-363, 2013.

- Pathogenesis of hepatocellular carcinoma: new ideas for a targeted therapy. M. Arciello, C. Balsano. Hot Topics in Viral Hepatitis. Sex, liver disease, and response to antiviral therapy - Women in hepatology – 2nd ed., 27: 2013.

- Are Hedgehog and Wnt/ß-catenin pathways involved in hepatitis C virus-mediated EMT? B. Conti, A. Minutolo, M. Arciello, C. Balsano. J Hepatol, 58(3): 636-637, 2013. 

- Focal adhesion kinase mediates a pro-invasive and pro fibrogenic phenotype in hepatitis C virus infected liver cells. A. Alisi, M. Arciello, S. Petrini, B. Conti, G. Missale, C. Balsano. PLoS One, 7(8): e44147, 2012.

- Hepatitis C in the elderly: a multicentre cross-sectional study by the Italian Association for the Study of the Liver. A. Gramenzi, F. Conti, C. Cammà, A. Grieco, A. Picciotto, C. Furlan, D. Romagno, P. Costa, M. Rendina, F. Ancarani, M. Chiaramonte, G. Verucchi, A. Craxì, M. Bernardi, P. Andreone; AISF HepaElder Study Group. Digest Liver Dis, 44(8): 674-680, 2012.

- Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. M. Arciello, S. Petta, V. Leoni, G. Iannucci, G. Labbadia, S. Sofia, C. Camma, A. Craxi, C. Balsano. Digest Liver Dis, 44(3): 245-250, 2012.

- Hepatitis C virus and alcohol: same mitotic targets but different signaling pathways. A. Alisi, M. Ghidinelli, A. Zerbini, G. Missale, C. Balsano. J Hepatol, 54(5): 956-963, 2011.

- Functions and therapeutic value of Focal Adhesion Kinase signaling during hepatocellular carcinoma development and progression. A. Alisi, C. Balsano. Hepatology, 51(3): 1092-1093, 2011.

- 7-ketocholesterol and 5,6-secosterol modulate differently the stress-activated mitogen-activated protein kinases (MAPKs) in liver cells. S. Anticoli, M. Arciello, A. Mancinetti, M. De Martinis, L. Ginaldi, L. Iuliano, C. Balsano. J Cell Physiol, 222(3): 586-595, 2010.

- Involvement of PI3K in HCV-related lymphoproliferative disorders. A. Alisi C. Giannini, A. Spaziani, P. Caini, A.L. Zignego, C. Balsano. J Cell Physiol, 214(2): 396-404, 2008.

- PKR is a novel functional direct player that coordinates skeletal muscle differentiation via p38MAPK/AKT pathways. A. Alisi, A. Spaziani, S. Anticoli, M. Ghidinelli, C. Balsano. Cell Signal, 20(3): 534-542, 2008.

- Role of p38MAPK and PKR in HCV core-dependent nuclear delocalization of cyclin B1. A. Spaziani, A. Alisi, D. Sanna, C. Balsano. J Biol Chem, 281(16): 10983-10989, 2006.

- Thr 446 phosphorylation of PKR by HCV core protein deregulates G2/M phase in HCC cells. A. Alisi, R. Mele, A. Spaziani, S. Tavolaro, E. Palescandolo, C. Balsano. J Cell Physiol, 205(1):25-31, 2005.

- Physical and functional interaction between HCV core protein and the different p73 isoforms. A. Alisi, S. Giambartolomei, F. Cupelli, P. Merlo, G. Fontemaggi, A. Spaziani, C. Balsano. Oncogene, 22(17): 2573-2580, 2003.

- DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. A. Costanzo, P. Merlo, N. Pediconi, M. Fulco, V. Sartorelli, P.A. Cole, G. Fontemaggi, M. Fanciulli, L. Schiltz, G. Blandino, C. Balsano, M. Levrero. Mol Cell, 9(1):175-186, 2002.