• Istituto di Biologia e Patologia Molecolari

MARTA MARZULLO

EDUCATION
01/11/2013-31/10/2016 PhD student Department of Biology and Biotechnologies “C. Darwin”,
Sapienza, University of Rome. Italy
Advisor: Laura Ciapponi and Maurizio Gatti
Thesis title: “pendolino (peo), a Drosophila gene preferentially required for heterochromatic telomeres protection”

1/10/2011-25/07/2013 Master’s degree in Genetics and Molecular Biology
Department of Biology and Biotechnologies “C. Darwin”,
Sapienza, University of Rome. Italy 
Supervisor: Laura Ciapponi
Thesis title: Role of pendolino gene in the heterochromatic telomeres stability in Drosophila melanogaster 
Vote: 110/110 summa cum laude

1/10/2008-28/10/2011 University degree in Biology
Department of Biology and Biotechnologies “C. Darwin”,
Sapienza, University of Rome. Italy
Supervisor: Laura Ciapponi
Thesis title: Identification of mutations in mitotic and telomere genes associated to Drosophila melanogaster chromosome II 
Vote: 110/110 summa cum laude

POST-LAUREAM EXPERIENCE

CURRENT POSITION
01/07/2019-to date Postdoctoral Researcher 
Department of Biology and Biotechnologies “C. Darwin”,
Sapienza, University of Rome. Italy
Institute of Molecular Biology and Pathology (IBPM-CNR)
Advisor: Laura Ciapponi and Maurizio Gatti
Project : “The role of pendolino gene in epigenetics telomere maintenance and its interaction with PEV (Position Effect Veriegation) modifiers”

PAST POSITION
01/01/2018-30/06/2019 Postdoctoral Researcher 
Telomere and Genome stability group,
Insituto Gulbenkian de Ciência (IGC), Oeiras, Portugal
Advisor: Miguel Godinho Ferreira
Project : “Age as a Carcinogen – are Telomeres the culprit?”
I worked on the characterization of the systemic effect of telomere shortening, using the model system Danio Rerio (Zebrafish). We use the telomerase mutant (tert-/-) to dissect the consequences of telomere attrition at cell and tissue level. Ultimately, aiming to define the pathways involved in aging in human and to contribute to find therapy for aging-associated diseases.

15/11/2016- 30/11/2017 Postdoctoral Researcher 
Department of Biology and Biotechnologies “C. Darwin”,
Sapienza, University of Rome. Italy
Advisor: Laura Ciapponi and Maurizio Gatti
Project : “Exploiting the Drosophila model system to investigate the function of human proteins involved in telomere maintenance”

PUBLICATIONS
1. Lex K.*, Gil M.*, Figueira M., Marzullo M., Lopes-Bastos B., Giannetti K., Carvalho T, Ferreira M.G. Telomere shortening produces an inflammatory environment that promotes tumor invasiveness in zebrafish. Manuscript under revision in PNAS. bioRxiv 844084;doi:https://doi.org/10.1101/844084.

2. El Maï M.*, Marzullo M.*, Pimenta de Castro I*. and Ferreira M.G. "Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish" . Manuscript accepted in eLife. Online from June 2020

3. Strah N., Romano G., Introna C., Klima R., Marzullo M., Ciapponi L., Megighian A., Nizzardo M., Feiguin F. TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles. BMC Biol. 2020 Mar 26;18(1):34. doi: 10.1186/s12915-020-00767-7.

4. Razzoli M., Dufe K., Gurney A., Erickson C., McCallum J., Spielman N., Marzullo M., Patricelli J., Kurata M., Touma C., Palme R., Largaespada D., Allison D.B., Bartolomucci A. Social Stress Regulates Lifespan in Mice. Aging Cell. 2018 May 28:e12778. doi: 10.1111/acel.12778. 

5. Blum J.A.*, Bonaccorsi S.*, Marzullo M., Palumbo V., Barbash D.A. and Gatti M. The Lhr-Hmr complex is required for sister chromatid separation during anaphase but not for centromere/kinetochore function. Genetics. 2017;207: 1457–1472. doi:10.1534/genetics.117.300390. 

6. Marzullo M., Gatti M. Telomere fusion in Drosophila: The role of subtelomeric chromatin. Fly (Austin). 2015 Jul 3;9(3):121-5. doi:10.1080/19336934.2015.1131882. 

7. Cenci G.*, Ciapponi L.*, Marzullo M., Raffa G.D., Morciano P., Raimondo D., Burla R., Saggio I., Gatti M. The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres. PLoS Genet. 2015 Jun 25;11(6):e1005260. doi: 10.1371/journal.pgen.1005260. eCollection 2015 Jun.