• Istituto di Biologia e Patologia Molecolari

ANNA FRAPPAOLO

EDUCATION
• February 6, 2017 PhD Degree in Life Science (XXIX cycle), Classification: Excellent; “Sapienza” Università di Roma,
• October 3, 2013 Second Level degree cum laude in Genetics and Molecular Biology, “Sapienza” Università di Roma, under the supervision of Dr. Maria Grazia Giansanti.
• December 13, 2011 First Level degree cum laude in Biological Sciences, “Sapienza” Università di Roma.

POST-LAUREAM EXPERIENCE
• April 2023 Postdoctoral fellow at IBPM-CNR; Project title: “SNAP29/COG interplay in physiology and disease”; project funded by MUR/PRIN_2020 (PI, Dr. Giansanti).
• April 2020-April 2023 Postdoctoral fellow at IBPM-CNR; Project title: “Golgi phosphoprotein 3 and membrane trafficking in cytokinesis and cell proliferation”; project funded by AIRC (PI, Dr. Giansanti).
• March 2017- February 2020 CNR-IBPM Researcher, III level (Dr. Giansanti Lab); TD supported by FIRC/AIRC fellowship; research project “The oncoprotein GOLPH3 and membrane trafficking during cytokinesis”
• November 2013- February 2017 PhD student in Dr. Maria Grazia Giansanti lab; research activity focused on the oncoprotein GOLPH3 and membrane trafficking during Drosophila cytokinesis.
• January 2012-October 2013 Internship (laurea magistralis/Second level degree in Genetics and Molecular Biology) under the supervision of Dr. Maria Grazia Giansanti. Cytological and molecular characterization of sauron and doublefault, two mutants affecting male meiosis in Drosophila.
• June 2011-December 2011 Internship (First level degree in Biological Science) under the supervision of Dr. Maria Grazia Giansanti. Cytological characterization of doublefault, a mutant affecting male meiosis in Drosophila.

Awards
Certificate of merit “Donne,genere: Sapienza”, this award was assigned to the best female students, who obtained the degree at Sapienza University in 2013, Roma ITA, September 11, 2014.

PUBLICATIONS
1. Frappaolo A., Karimpour-Ghahnavieh A., Cesare G., Sechi S., Fraschini R., Vaccari T., Giansanti M.G. GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila. Cell Death Dis. 2022. 13:1003.
2. Frappaolo A., Piergentili R., Giansanti M.G. Microtubule and Actin Cytoskeletal Dynamics in Male Meiotic Cells of Drosophila melanogaster. Cells. 2022. 11: 695.
3. Sechi S., Karimpour-Ghahnavieh A., Frappaolo A.*, Di Francesco L., Piergentili R., Schininà E., D'Avino P.P., Giansanti M.G. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Cells. 2021. 10: 2336.
* primo autore in condivisione
4. Frappaolo A. *, Karimpour-Ghahnavieh A., Sechi S., Giansanti M.G. The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation. Cells. 2020. 9: 2652.
* co-corrisponding
5. Sechi S., Frappaolo A. *, Karimpour-Ghahnavieh A., Fraschini R., Giansanti M.G. A novel coordinated function of Myosin II with GOLPH3 controls centralspindlin localization during cytokinesis in Drosophila. Journal of Cell Science. 2020. 133: jcs252965.
* primo autore in condivisione
6. Sechi S., Frappaolo A. *, Karimpour-Ghahnavieh A., Piergentili R., Giansanti M.G. Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer. Int J Mol Sci. 2020. 21. pii: E933.
* primo autore in condivisione
7. Sechi S., Frappaolo A. *, Karimpour-Ghahnavieh A., Gottardo M., Burla R., Di Francesco L., Szafer-Glusman E., Schininà E., Fuller M.T., Saggio I., Riparbelli M.G., Callaini G., Giansanti M.G. Drosophila Doublefault protein coordinates multiple events during male meiosis by controlling mRNA translation. Development. 2019.146. pii: dev183053.
* primo autore in condivisione
8. Frappaolo A., Sechi S., Kumagai T., Karimpour-Ghahnavieh A., Tiemeyer M., Giansanti M.G. Modeling Congenital Disorders of N-Linked Glycoprotein Glycosylation in Drosophila melanogaster. Frontiers in Genetics. 2018. 9:436.
9. Frappaolo A., Sechi S., Kumagai T., Robinson S., Fraschini R., Karimpour-Ghahnavieh A., Belloni G., Piergentili R., Tiemeyer K.H., Tiemeyer M., Giansanti M.G. COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes. Journal of Cell Science. 2017. 130: 3637-3649.
10. Sechi S., Frappaolo A.*, Fraschini R., Capalbo L., Gottardo M., Belloni G, Glover D.M., Wainman A., Giansanti M.G. Rab1 interacts with GOLPH3 and controls Golgi structure and contractile ring constriction during cytokinesis in Drosophila melanogaster. Open Biology. 2017. 7. pii: 160257.
* primo autore in condivisione
11. Frappaolo A., Sechi S., Belloni G., Piergentili R., Giansanti M.G. Visualization of cleavage furrow proteins in fixed dividing spermatocytes. Methods in Cell Biology. 2017; 137:85-103.
12. Giansanti M.G., Vanderleest T.E., Jewett C.E., Sechi S., Frappaolo A., Fabian L., Robinett C.C., Brill J.A., Loerke D., Fuller M.T., Blankenship J.T. Exocyst-Dependent Membrane Addition Is Required for Anaphase Cell Elongation and Cytokinesis in Drosophila. PLoS Genetics. 2015. 11: e1005632.
13. Sechi S., Frappaolo A.*, Belloni G., Colotti G., Giansanti M.G. The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3. Oncotarget. 2015. 6:3493-3506.
* primo autore in condivisione
14. Sechi S., Frappaolo A., Belloni G., Giansanti M.G. The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis. Biochemical Society Transactions. 2015. 43:117-121.
15. Sechi S., Colotti G., Belloni G., Mattei V., Frappaolo A., Raffa G.D., Fuller M.T., Giansanti M.G. GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster. PLoS Genetics. 2014.10: e1004305.
16. Giansanti M.G., Sechi S., Frappaolo A., Belloni G. and Piergentili R. Cytokinesis in Drosophila male meiosis. Spermatogenesis. 2012. 2:185–196.