Tel :+390649912213
Fax :+390649912500
julie.martone@uniroma1.it
Fax :+390649912500
julie.martone@uniroma1.it
JULIE MARTONE
Researcher
Istitute of Molecular Biology and Pathology - National Research Council
Department of Biology and Biotecnology - Charles Darwin
Sapienza University of Rome - General Physiology Building - basement Room 30 - P.le A.Moro 5, 00185 Rome
Researcher
Istitute of Molecular Biology and Pathology - National Research Council
Department of Biology and Biotecnology - Charles Darwin
Sapienza University of Rome - General Physiology Building - basement Room 30 - P.le A.Moro 5, 00185 Rome
| 1. Epigenetic, transcriptional and post-transcriptional gene regulation mediated by non-coding RNAs (long non-coding RNAs, microRNAs, circular RNAs) 2. Role of non-coding RNAs in muscle differentiation and pathology (Duchenne Muscular Dystrophy) 3. Role of miRNAs as serum biomarkers (Duchenne Muscular Dystrophy, Amyotrophic lateral sclerosis, individual’s response to microgravity exposure) 4. Duchenne Muscular Dystrophy therapeutic approaches |
| 1. Martone J., Lisi M., Castagnetti F., Rosa A., Di Carlo V., Blanco E., Setti A., Mariani D., Colantoni A., Santini T., Perone L., Di Croce L. and Bozzoni I. (2020). Transgenerational epigenetic regulation drives the amelioration of a Duchenne Muscular Dystrophy phenotype. EMBO Mol Med (2020) e12063 (I.F. 10,2). 2. Martone J., Mariani D., Shamloo S., Santini T., Colantoni A., Setti A., Capparelli F., A Paiardini A., Dimartino D., Morlando M., Bozzoni I. (2020). SMaRT lncRNA controls translation of a G-quadruplex containing mRNA antagonizing the DHX36 helicase. EMBO Reports (2020) e49942 (I.F. 7,8) 3. Martone J., Mariani D., Desideri F. and Ballarino M. (2020). Non-coding RNAs Shaping Muscle. Front. Cell Dev. Biol. https://doi.org/10.3389/fcell.2019.00394 (I.F. 5,2) 4. Dimartino D., Colantoni A., Ballarino M., Martone J., Mariani D., Danner J., Bruckmann A., Meister G., Morlando M., Bozzoni I. (2018). The Long Non-coding RNA lnc-31 Interacts with Rock1 mRNA and Mediates Its YB-1-Dependent Translation. Cell Rep. 23(3):733-740. (I.F. 8,2) 5. Martone J., Briganti F., Legnini I., Morlando M., Picillo E., Sthandier O., Politano L., Bozzoni I. (2016) The lack of the Celf2a splicing factor converts a Duchenne genotype into a Becker phenotype. Nat Commun. 7:10488. (I.F. 11,470) 6. Spallotta F., Tardivo S., Nanni S., Rosati J.D., Straino S., Mai A., Vecellio M., Valente S., Capogrossi M.C., Farsetti A., Martone J., Bozzoni I., Pontecorvi A., Gaetano C., Colussi C. (2013) Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia. J Biol Chem. 288(32):22915-29. (I.F. 4,570) 7. Martone J., Cazzella V., Pinnarò C., Santini T., Twayana S.S., Sthandier O., D'Amico A., Ricotti V., Bertini E., Muntoni F., Bozzoni I. (2012) Exon 45 skipping through U1-snRNA antisense molecules recovers the Dys-nNOS pathway and muscle differentiation in human DMD myoblasts. Mol Ther. 20(11):2134-42. (I.F. 6,825) 8. Cacchiarelli D., Legnini I., Martone J., Cazzella V., D'Amico A., Bertini E. and Bozzoni I. (2011) miRNAs as serum biomarkers for Duchenne Muscular Dystrophy. EMBO Mol. Med. 3(5):258-65. (I.F. 8,665) 9. Cacchiarelli D., Incitti T., Martone J., Cesana M., Cazzella V., Santini T., Sthandier O., Bozzoni I. (2011) miR-31 modulates dystrophin expression: new implications for Duchenne muscular dystrophy therapy. EMBO Rep. 12(2):136-41. (I.F. 9,055) 10. Martone J., Cacchiarelli D., Girardi E., Cesana M., Incitti T., Morlando M., Nicoletti C., Santini T., Sthandier O., Barberi L., Auricchio A., Musarò A., Bozzoni I. (2010) miRNAs involved in molecular circuitries relevant for the DMD pathogenesis are controlled by the dystrophin/nNOS pathway. Cell Metab. 12(4):341-51. (I.F. 17,565 |
| Irene Bozzoni, Dept. of Biology and Biotechnology C.Darwin, Sapienza University of Rome Antonio Musarò, Medical and Biotechnology School, Sapienza University of Rome Monica Ballarino, Dept. of Biology and Biotechnology C.Darwin, Sapienza University of Rome Mariangela Morlando, Dept of Pharmaceutical Sciences, University of Perugia, Perugia, Italy |
| Education and Professional Experience - 2020 to date: CNR permanent researcher, III level. - 2016-2020: RTD-A Researcher, University of Rome “Sapienza”. - 2007-2016: Post-doctoral Fellow, University of Rome “Sapienza”. - 2006: PhD in Genetics and Molecular Biology, University of Rome “Sapienza”. - 2003: Degree (110/110 cum laude) in Biological Sciences, University of Rome “Sapienza”. Academic Activities - 2020-present: Assistant ("cultore della materia") in "Molecular biology of stem cells" for the Laurea Magistrale (Master Degree) course in "Genetics and Molecular Biology in Basic and Biomedical Research", SAPIENZA University of Rome, Faculty of Science - 2017-2020: Course in "Molecular biology of stem cells" for the Laurea Magistrale (Master Degree) course in "Genetics and Molecular Biology in Basic and Biomedical Research", SAPIENZA University of Rome, Faculty of Science - 2007-2020: Supervisor of students in their undergraduate and PhD projects in Molecular Biology, SAPIENZA University of Rome, Faculty of Science - 2006 -2007: Assistant ("cultore della materia") in Genetic Engineering, University of Rome "La Sapienza", Faculty of Science - Lecturer as invited speaker in high formation courses (PhD courses) Honours and awards - 2018: Conseguimento dell’Abilitazione Scientifica Nazionale, II Fascia. Settore concorsuale:05/E2 - Biologia molecolare. - Holder of 3 patents (US 20120129920 A1, WO 2011154427 A1, US20120115150 A1). Projects as Principal Investigator ATENEO "Progetti medi" (2019- 2020):"New therapeutic approach for Duchenne Muscular Dystrophy" Participation to National and International (EU) Research Projects AGENZIA SPAZIALE ITALIANA Project (2019-present):“MARS-PRE: MARcatori biologici e funzionali per la biomedicina aStronautica di PREcisione”. ATENEO "Progetti Medi" (2017- present): "Dissecting the role of the long non-coding RNA Charme in cardiomyogenesis". EUROPEAN ERC AdG Project MUNCODD (2014-2020): "Role of long non-coding RNA in muscle differentiation and disease". TELETHON 2016 (2017-2020): "RNA-based studies of Duchenne Muscular Dystrophy: post-transcriptional control and role of non-coding RNAs in normal and dystrophic muscle development" Regione Lazio Progetti di R&S in collaborazione da parte delle PMI del Lazio (2014- 2015): "micro RNA biomarkers for the diagnosis and the follow-up of degenerative diseases". TELETHON 2011 (2011-1015) EPIGEN (2013) - Progetto Bandiera Epigenomica del CNR: "Role of long non-coding RNAs in cell differentiation and disease". FIRB (2010) - Project: "Micro-RNA: dai meccanismi alle applicazioni diagnostiche e terapeutiche". Fondazione Pasteur Cenci Bolognetti (2009-2012): "RNA-RNA and RNA-protein interactions: role of small non-coding RNAs in gene expression control". EUROPEAN Integrated Project SIROCCO - LSHG-CT (2006-037900): "Silencing RNAs: organisers and coordinators of complexity in eukaryotic organisms". |