• Istituto di Biologia e Patologia Molecolari


Tel :+390649912472
Fax :+390649912343
romina.burla@uniroma1.it
ROMINA BURLA
Researcher

Istitute of Molecular Biology and Pathology - National Research Council
Department of Biology and Biotecnology - Charles Darwin
Sapienza University of Rome - Istituto Genetica III, floor room 310 - P.Le A.Moro 5 00185 Roma

My main research interests are focused on the following subjects: 

- TELOMERES: my research in this field is focused on telomere maintenance mechanisms and their impact in relevant physiological and pathological processes. I am also interested in understanding how telomeres and chromatin are organized inside the nucleus.

- NUCLEAR ENVELOPE: I am interested in studying the cellular processes needed to ensure nuclear envelope integrity and in understanding how this relates with genome organization and stability, in physiological and pathological processes (mainly aging and cancer).

- AGING: my research in this field is aimed at the elucidation of molecular and cellular processes involved in physiological aging and premature aging syndromes.

- VIRAL VECTORS: These are powerful tools to be used and characterized for gene therapy purposes and for reverse genetics studies.

- ADVANCED MICROSCOPY TECHNIQUES: I am interest in the technology and in its innovation for its use in studying cellular complexes and their involvement in essential biological processes.
  1. Burla R, La Torre M, Maccaroni K, Vernì F, Giunta S, Saggio I. Interplay of the nuclear envelope with chromatin in physiology and pathology. Nucleus 2020
  2. Merigliano C, Burla R, La Torre M, Del Giudice S, Teo Hsiang L, Chong Wai L, Goh WI, Chojnowski A, Chiolo I, Carlton J, Raimondo D, Verni F, Rhodes D, Wright G, Burke B and Saggio I. Human AKTIP interacts with ESCRT proteins and functions at the midbody in cytokinesis. BioRXiv 2020
  3. Raimondo D, Remoli C, Astrologo L, Burla R, La Torre M, Vernì F, Tagliafico E, Corsi A, Del Giudice S, Persichetti A, Giannicola G, Robey PG, Riminucci R and Saggio I. Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone. Plos One 2020
  4. Sechi S, Frappaolo A, Karimpour-Ghahnavieh A, Gottardo M, Burla R, Di Francesco L, Szafer-Glusman E, Schininà E, Fuller M T, Saggio I, Riparbelli M G, Callaini G, and Giansanti M G. Drosophila Doublefault protein coordinates multiple events during male meiosis by controlling mRNA translation. Development 2019
  5. Burla R, La Torre M, Zanetti G, Bastianelli A D, Merigliano C, Del Giudice S, Vercelli A, Di Cunto F, Boido M, Vernì F and Saggio I. p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice. Frontiers in genetics 2018.
  6. Burla R, la Torre M, Merigliano C, Vernì F and Saggio I Genomic instability and DNA replication defects in progeroid syndromes. Nucleus 2018.
  7. La Torre M, Merigliano C, Burla R, Mottini C, Zanetti G, Del Giudice S, Carcuro M, Virdia I, Bucciarelli E, Manni I, Rampioni Vinciguerra G, Piaggio G, Riminucci M, Cumano A, Bartolazzi A, Vernì F, Soddu S, Gatti M, Saggio I Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits Aging cell, 2018
  8. Burla R, Carcuro M, La Torre M, Fratini F, Crescenzi M, D’Apice MR, Spitalieri P, Raffa GD, Astrologo L, Lattanzi G, Cundari E, Raimondo D, Biroccio A, Gatti M and Saggio I The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence Open Biol, 2016
  9. Burla R, La Torre M, Saggio I Mammalian telomeres and their partnership with lamins Nucleus 2016
  10. Burla R, Carcuro M, Raffa G, Galati A, Raimondo D, Rizzo A, La Torre M, Micheli E, Ciapponi L, Cenci G, Cundari E, Musio A, Biroccio A, Cacchione S, Gatti M, Saggio I AKTIP/Ft1, a new shelterin-interacting factor required for telomere maintenance Plos Genetics 2015
Isabella Saggio, Dip. Biologia e Biotecnologie C. Darwin, Sapienza, Università di Roma
Marinella Pirozzi, IBBC-CNR, Napoli

February 2012: PhD in Genetics and Molecular Biology, Dept of Biology and Biotechnology “C Darwin”, Sapienza, University of Rome. PhD thesis title “Characterization of AKTIP, a new protein involved in human DNA replication and telomere metabolism”. Group Leader: Prof. Isabella Saggio

April 2008: Master Degree in Genetics and Molecular Biology (110/110 cum laude) Dept of Genetics and Molecular Biology, University “La Sapienza”, Rome

December 2006: University Degree in Biological Sciences (110/110 cum laude) Dept of Genetics and Molecular Biology, University “La Sapienza”, Rome

 

Professional Experience

 

July 2020-Present: IBPM-CNR Researcher, III professional level, permanent position

March 2018-June 2020: Postdoctoral research activity in the field of telomere metabolism and replication and aging related processes in mammalian cells Dept of Biology and Biotechnology “C Darwin”, Sapienza, University of Rome Group leader: Prof. Isabella Saggio

January 2016- February 2018: Postdoctoral research activity in the field of telomere metabolism and replication in mammalian cells. IBPM CNR/ Dept of Biology and Biotechnology “C Darwin”, Sapienza.

May 2014 – December 2015: Postdoctoral research activity in the field of telomere metabolism and replication and aging related processes in mammalian cells Dept of Biology and Biotechnology “C Darwin”, Sapienza, University of Rome Group leader: Prof. Isabella Saggio                

May 2013-April 2014: Postdoctoral research activity in the field of telomeres metabolism Dept of Biology and Biotechnology “C Darwin”, Sapienza, University of Rome Group leader: Prof. Isabella Saggio I

May 2012-April 2013: Research scolarship of Pasteur Institute-Fondazione Cenci Bolognetti (Teresa Ariaudo) in the field of telomere in mammalian cells Dept of Biology and Biotechnology “C Darwin”, Sapienza, University of Rome Group leader: Prof. Isabella Saggio

November 2011-May 2012: Postdoctoral research activity in the field of telomere metabolism and replication and aging related processes in mammalian cells Dept of Biology and Biotechnology “C Darwin”, Sapienza, University of Rome Group leader: Prof. Isabella Saggio

 

2009-2012: Collaborations in European research project: “Braincav”. Project and Grants

2021- ongoing: Collaboration in AIRC founded project: “Nuclear envelope and telomere instability in lymphomagenesis”.

2016-2019: Collaboration in Progeria Research Foundation founded project: “The lamin-interacting telomeric protein AKTIP in HGPS”.

2015-2016: Collaboration in Telethon founded Exploratory project: “Investigating the role of the telomeric gene AKTIP in progeroid syndromes”.

2010-2016: Collaborations in AIRC founded project: “Identification and characterization of Drosophila telomere capping proteins”.

 

Grants

2018:   MIUR Ateneo Avvio alla ricerca. Project title “Analysis of the biochemical and functional role of the telomeric protein AKTIP/Ft1 in telomere replication”. PI

2015:   MIUR Ateneo Avvio alla ricerca. Project title “Study of the genetic interaction between the telomeric protein AKTIP/Ft1 and the genome surveyor p53”. PI