• Istituto di Biologia e Patologia Molecolari


Tel :0649913401 (studio); 0649913617 (lab.)
Fax :0649913628
paolo.bovicelli@uniroma1.it
PAOLO BOVICELLI
Research Director

Istitute of Molecular Biology and Pathology - National Research Council
Department of Chemistry
Sapienza University of Rome - Edificio di Chimica, edificio Cannizzaro (VEC) Piano terzo, stanza 320 (lab: 319) P.le A. Moro 5 - 00185 Roma
Development of new methodologies for the synthesis of natural compounds and biomolecules utilising organometallic, reductive and oxidising reagents with high chemo-, regio- and diastereoselectivity.
Chemo- and regioselective oxidation of natural compounds by dimethyldioxirane.
Studies on the preparation and reactivity of new chiral dioxiranes.
Synthesis of flavonoids and isocoumarines for the preparation of biologically interesting derivatives.
Synthesis of lipid long chain compounds with a polar head (poliols, aminoalchols) to use as lipase inhibitors.
Synthesis and bioactivity investigation of polyphenols via oxyfunctionalization of natural targets.
Polyphenols are molecules with antioxidant properties contained in every kind of plant. The specific properties of these molecules are due to the presence of aromatic moieties and of many hydroxyl groups. Natural antioxidants endowed with such structural characteristics (such as flavonoids, gallic acid, resveratrol, ubiquinones and hydroxytyrosol) are considered of paramount importance for their potential employment in foods and drugs. 
Synthesis of obatoclax analogs with long aliphatic chains in order to obtain compounds with an enhanced activity. Obatoclax is an effective inhibitor of Bcl-2, is the basis of drugs that are still being studied for their alleged effectiveness to reactivate the mechanism of apoptosis in cases of resistant cells to chemotherapy.
1.Banerjee, P.; Sahoo, A.; Anand, S.; Ganguly, A.; Righi, G.; Bovicelli, P.; Saso, L.; Chakrabarti, S. "Multiple Mechanisms of Iron-Induced Amyloid Beta-Peptide Accumulation in SHSY5Y Cells: Protective Action of Negletein" Neuromolecular medicine 2014, 16(4), 787-98. DOI:10.1007/s12017-014-8328-4.

2.Riha, M.; Karlickova, J.; Filipsky, T.; Macakova, K.; Rocha, L.; Bovicelli, P.; Proietti Silvestri, I.; Saso, L.; Jahodar, L.; Hrdina, R.; Mladenka, P. “In vitro evaluation of copper-chelating properties of flavonoids” RSC Advances 2014, 4(62), 32628-32638.

3.Righi, G.; Bovicelli, P.; Tirotta, I. “New one-pot procedure for the synthesis of diprotected amino alcohols from unprotected vinyl aziridines”   Tetrahedron Letters 2013, 54(48), 6439-6442. DOI: 10.1016/j.tetlet.2013.09.047.

4.Barontini, M.; Proietti Silvestri, I.; Nardi, V.; Bovicelli, P.; Pari, L.; Gallucci, F.; Spezia, R.; Righi, G. “Easy eco-friendly phenonium ion production from phenethyl alcohols in dimethyl carbonate” Tetrahedron Letters 2013, 54(37), 5004-5006. DOI: 10.1016/j.tetlet.2013.06.122.

5.Lombardo, E.; Sabellico, C.; Hajek, J.; Stankova, V.; Filipsky, T.; Balducci, V.; De Vito, P. ; Leone, S.; Bavavea, E. I.; Proietti Silvestri, I.; Righi, G.; Luly, P.; Saso, L.; Bovicelli, P.; Pedersen, J. Z.; Incerpi, S. “Protection of Cells against Oxidative Stress by Nanomolar Levels of Hydroxyflavones Indicates a New Type of Intracellular Antioxidant Mechanism” Plos One 2013, 8(4), e60796. DOI: 10.1371/journal.pone.0060796.

6.Barontini, M.; Proietti Silvestri, I.; Nardi, V.; Crisante, F.; Pepe, G.; Pari, L.; Gallucci, F.; Bovicelli, P.; Righi, G. “Synthesis and biological evaluation of gallic acid analogs” Medicinal Chemistry Research 2013, 22(2), 674-680. DOI: 10.1007/s00044-012-0052-8.

7.Macakova, K.; Mladenka, P.; Filipsky, T.; Riha, M.; Jahodar, L.; Trejtnar, F.; Bovicelli, P.; Proietti Silvestri, I.; Hrdina, R.; Saso, L.  “Iron reduction potentiates hydroxyl radical formation only in flavonols”  Food Chemistry 2012, 135(4), 2584-2592. DOI: 10.1016/j.foodchem.2012.06.107.

8.Righi, G.; Bovicelli, P.; Marucci, C.; Tirotta, I. “BF3 center dot OEt2/TMSN3 Mediated Regioselective Azidolysis of Vinylaziridines”  Synthesis-Stuttgart 2012, 44(20), 3202-3208. DOI: 10.1055/s-0032-1316768.

9.Righi, G.; Mandic', E.; Naponiello, G. C. M.; Bovicelli, P.; Tirotta, I. “Study on the stereochemical control of dihydroxylation of vinyl epoxides and their derivatives” Tetrahedron 2012, 68(14), 2984-2992. DOI: 10.1016/j.tet.2012.02.029.

10.Righi, G.; Bovicelli, P.; Barontini, M.; Tirotta, I. “Dimethyl carbonate in the regio- and stereocontrolled opening of three-membered heterocyclic rings” Green Chemistry 2012, 14(2), 495-502. DOI: 10.1039/c2gc16241e.
Dr. Paolo Bovicelli
Dr.ssa Giuliana Righi
Dr.ssa Alessandra Ricelli
Dr. Roberto Antonioletti
Work experience
 
CNR Matric. N.  02460
Qual.   Senior Researcher, Level I 
 
Education
1980: Degree in Chemistry, Sapienza University of Rome
 
Research experience

2014
IBPM-CNR (Institute of Biology e Molecular Patologies) Performs and coordinates laboratory activities. Writes publications on national and international journals, is supervisor of Master of Science thesis and PhD thesis. Is involved in the preparation of research projects with national and international settings. Is in the organizing committee of national and international conferences and meetings. 
2005-2013
Delegated from ICB-CNR (Institute of Biomolecular Chemistry) Director to the management of the resources and the predisposition of related documents to budget and balance for the unity of Rome
2000-2004
Head of ICB-CNR Section of Rome
1994-2001
Director of Center for the Study of the Chemistry of Natural Organic Substances (cscson) of CNR
1988-1989
Fellowship at Fachbereich Chemie Marburg University 
Organic synthesis: conversion of aldehydes into 1,1-dibromoalkanes