• Istituto di Biologia e Patologia Molecolari

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National Research Council
Istitute of Molecular Biology and Pathology CNR
Department of Biology and Biotecnology - Charles Darwin - Sapienza University of Rome
General research interest is the role of epigenetic and post-transcriptional mechanisms in gene expression control.

Current Research activities:
  • analysis of miRNA mediated post-transcriptional regulation in the nervous system, in stress related behavior and related pathologies
  • study of miRNA and RBP crosstalk mechanisms
  • identification and characterization of circRNAs deregulated in autism spectrum disorders, 
  • chemical and post-transcriptional control of JARID1 HDMs in human breast cancer cell lines
Publications 2015-2020
  • Capitano, F, J Camon, V Ferretti, V Licursi, F De Vito, A Rinaldi, S Vincenti, et al. “microRNAs Modulate Spatial Memory in the Hippocampus and in the Ventral Striatum in a Region-Specific Manner”. Molecular Neurobiology, August 26, (2015). doi:10.1007/s12035-015-9398-5. IF 5.397
  • Danovska, Svetlana, Enrico Cundari, Cecilia Mannironi, Valerio Licursi, Teresa Rinaldi, Simone Fabozzi, Valentina Cerini, et al. “In Vivo Selection of JARID Histone Demethylases Inhibitors and their Use to Enlighten the Biological Role of These Enzymes” in Yeast and Mammalian Cells with Focus on Transcriptional Regulation,” no.32 (2015):S176–76,.
  • de Angelis MH, Nicholson G, Selloum M, et al Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. Nat Genet 47, 2015: 969–978. doi: 10.1038/ng.3360
  • Del Vecchio, G., De Vito, F., Saunders, S. J., Risi, A., Mannironi, C., Bozzoni, I., Presutti, C. (2016). RNA-binding protein HuR and the members of the miR-200 family play an unconventional role in the regulation of c-Jun mRNA. RNA, 22(10), 1510-1521.
  • Capitano F., Camon J., Licursi V., Ferretti V., Maggi L., Scianni M., Del Vecchio G., Mannironi C., Limatola C., Presutti C., Mele A. (2017) MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity. Neurobiology of Learning and Memory 139:63–68. doi: 10.1016/j.nlm.2016.12.019
  • Mannironi C, Biundo A, Rajendran S, et al (2017) miR-135a Regulates Synaptic Transmission and Anxiety-Like Behavior in Amygdala. 1–15. doi: 10.1007/s12035-017-0564-9
  • Valerio Licursi, Mariangela Cestelli Guidi, Giorgia Del Vecchio, Cecilia Mannironi, Carlo Presutti, Roberto Amendola & Rodolfo Negri(2017) Leptin induction following irradiation is a conserved feature in mammalian epithelial cells and tissues, International Journal of Radiation Biology, 93:9, 947-957, DOI: 1080/09553002.2017.1339918
  • Mocavini, I., Pippa, S., Licursi, V., Paci, P., Trisciuoglio, D., Mannironi, C., ... & Negri, R. (2019). JARID 1B expression and its function in DNA damage repair are tightly regulated by mi RNA s in breast cancer. Cancer science110(4), 1232-1243.
  • Pippa, S., Mannironi, C., Licursi, V., Bombardi, L., Colotti, G., Cundari, E., ... & Silvestri, R. (2019). Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing JARID1B. Molecules24(9), 1739.
  • Gasparini, S., Licursi V., Presutti C., Mannironi C. (2020). Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. Molecular Neurobiology : 1-13.
  • Gasparini S., Del Vecchio G., Gioiosa S., Flati T., Castrignano' T., Legnini I., Licursi V., Ricceri L., Scattoni A.M., Rinaldi A., Presutti C. and Mannironi C., (2020). Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. Molecular Neurobiology, 1-13.
  • Gasparini S., Licursi V., Presutti C. and Mannironi C. (2020). The secret garden of neuronal circRNAs. Cells2020, 9(8), 1815; https://doi.org/10.3390/cells9081815


Prof. Carlo Presutti, Prof. Rodolfo Negri, IBPM associates, Sapienza University, Rome
Dr. Valerio Licursi, Sapienza University, Rome
Prof. Arianna Rinaldi, Dept of Biology and Biotechnology, Sapienza       University, Rome
Dr. Maria Luisa Scattoni, Dr. Laura Ricceri, Istituto Superiore di Sanità, Rome
Prof. Pascale Legault, University of Montreal, Canada
Dr. Tiziana Castrignanò, University of Tuscia, Department of Ecological and Biological          Sciences, Viterbo, Italy
Dr. Silvia Gioiosa, SCAI-Super Computing Applications and Innovation Department, CINECA, Rome, Italy
Cecilia Mannironi, Ph.D.
Via degli Apuli, 4 
Roma, 00185
Tel: +39-06-4457526/49917912
Indirizzo e-mail: cecilia.mannironi@uniroma1.it
1987 Ph.D. in Pharmacological Research, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy
1983 Biological Science Degree, Università degli Studi di Pisa, Pisa, Italy. Graduation Score: 110/110 cum laude 
2013- present: Staff Scientist IBPM, CNR, Rome, Italy
2008-2013: Visiting scientist IBPM, CNR, Rome, Italy
1991-2008: Staff Scientist IBCN, CNR, Monterotondo, Rome, Italy
1988 –1990: Post-doctoral Fellow, National Institutes of Health, NCI, Laboratory of Molecular Pharmacology, Chromatin Structure and Function Group (Dr. W.M. Bonner), Bethesda, MD, USA
1984 -1988: Research Fellow at Istituto di Ricerche Farmacologiche "Mario Negri", (Dr. Maurizio D’incalci), Milano, Italy 
1983-1984: Visiting Student at Istituto di Genetica, Universita’ degli Studi di Pisa (Prof. Roberto Barale) and Istituto di Mutagenesi e Differenziamento (Dr. Lorenzo Citti), CNR, Pisa, Italy
1981-1984: Undergraduate Student, Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy
2009-2017.  Lecturer of Molecular Neurobiology at the Master Degree in Neurobiology, Dept. of Biology and Biotechnology, Sapienza University of Rome, Italy (3 CFU).
2017- 2019. Lecturer of Molecular Neurobiology I, at the Master Degree in Neurobiology, Dept. of Biology and Biotechnology, Sapienza University of Rome, Italy (3 CFU).

Supervisor of undergraduate /master students, University of Rome
Seminars and laboratory teaching for High School students 

Peer Reviewer for the international journals Cell Communication and Signaling (Jan 2020), Scientific Reports (Nov 2017), Scientific Reports (Aug 2017), Life Scince (June 2017), Chemical Biology (March 2015). Peer Reviewer for the The Italian Ministry of Education, Universities and Research, Grants “Futuro in Ricerca” 2013. Member of REPRISE (Register of Expert Peer Reviewers for Italian Scientific Evaluation).
Cineca, grant Elixir-IIB HPC@CINECA: Analysis of alternatively spliced variantsranscriptome profiling of brain and biofluids in Autism Spectrum Disorder mouse models, 2020
Cineca, grant Elixir-IIB HPC@CINECA: Transcriptome profiling of brain and biofluids in Autism Spectrum Disorder mouse models, 2018
Short Term Mobility Program from CNR. Title: "Assessment of miR-135a activity as an RNA decoy to modulate CPEB1 regulation of mRNA translation: in vitro structural and functional studies of miR-135a-CPEB1 interactions", University of Montreal, Canada 13.04.2018-05.05.2018.
Partecipant to European Grants: LIFE2020-Regione Lazio - REG LAZIO; EUMODIC (The European MOuse DIsease Clinic), 2007; EURASNET (European alternative splicing network of excellence),
2006; EUCOMM (The European Mouse Genome Mutagenesis Program), 2006; MUGEN (Integrated functional genomics in mutant mouse models as tools to
investigate the complexity of human immunological disease), 2005.
Participant to Italian Grants: MIUR-FIRB 2005; Sapienza Universita' di Roma
“Basi molecolari neuroanatomiche della memoria” 2009; PRIN “Ruolo dei Fattori Regolativi Generali (GRF) di S.cerevisiae nell'organizzazione strutturale e dinamica della cromatina” 2009.

C.M. is a member of the EUMODIC Consortium (http://www.eumodic.org), for mouse functional genomics and phenotyping, built on the work in the EUMORPHIA project funded by the European Commission under the Framework 6 (Programme contract number LSHG-CT-2006-037188).

Member of the European Molecular and Cellular Cognition Society (EEMCCS)
Member of Società' Italiana di Biofisica e Biologia Molecolare (SIBBM)
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ASD-related circRNAs