• Istituto di Biologia e Patologia Molecolari

Tel :+39064991224127
Fax :+390649912500
Senior Associate

Sapienza University of Rome
Istitute of Molecular Biology and Pathology CNR
Department of Biology and Biotecnology - Charles Darwin - Sapienza University of Rome P.le A.Moro 5 - 00185 Roma

Myc in cancer and its inhibition as therapy

•Neurotrophins in neural differentiation, survival and plasticity

•Epigenetic mechanisms in differentiation and cancer

•Gene regulatory networks


•Annibali D, Gioia U, Savino M, Laneve P, Caffarelli E, Nasi S. A new module in neural differentiation control:  two microRNAs upregulated by retinoic acid, miR-9 and -103, target the differentiation inhibitor ID2. 2012. PLoS One, 7(7):e40269

•Savino M, Annibali D, Carucci N, Favuzzi E, Cole MD, Evan GI, Soucek L, Nasi S. The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy. 2011. PLoS One, 6: e22284

•Ciarapica R, Annibali D, Raimondi L, Savino M, Nasi S, Rota R. Targeting Id protein interactions by an engineered HLH domain induces human neuroblastoma cell differentiation. 2009. Oncogene, 28: 1881-1889

•Soucek L, Whitfield J, Martins C, Finch A, Murphy D, Sodir N, Kamezis A, Brown Swigart L, Nasi S & Evan G. 2008. Modelling Myc inhibition as a cancer therapy. Nature 455: 679-683

•Presutti C, Rosati J, Vincenti S, Nasi S. 2006. Non coding RNA and brain. BMC Neuroscience 7, Suppl 1: S5

•Soucek L, Nasi S & Evan G. 2004. Omomyc expression in skin prevents Myc-induced papillomatosis.  Cell Death Differ. 11: 1038-1045

•Ciarapica R, Rosati J, Cesareni G & Nasi S. 2003. Molecular recognition in HLH and HLHZip domains: design of repertoires and selection of high affinity ligands for natural HLH proteins.  J. Biol. Chem. 278, 12182-12190

•Mandolesi G, Gargano S, Pennuto M, Illi B, Molfetta R, Soucek L, Mosca L, Levi A, Jucker R & Nasi S. NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction. FEBS Lett. 510: 50-56 (2002)

•Soucek L, Jucker R, Panacchia L, Ricordy R, Tatò F & Nasi S. 2002. Omomyc, a potential Myc dominant negative, enhances Myc-induced apoptosis. Cancer Res. 62: 3507-3510

•Soucek L, Helmer-Citterich M, Sacco A, Jucker R, Cesareni G & Nasi S. 1998. Design and properties of a Myc derivative that efficiently homodimerizes. Oncogene 17: 2463-2472

Sergio Nasi (first researcher)

Barbara Illi (researcher)

Mauro Savino (post-doc)

Chiara Lasco (master degree student)

Fiorella Scagnoli (master degree student)

Nicola Mattugini (master degree student)

Sara Beji (master degree student)

Nicola Rizzo (CNR technician)

Sergio Nasi CNR first researcher)

Barbara Illi (CNR researcher)

Mauro Savino (post-doc)

Nicola Mattugini (fellow)

Sara Beji (fellow)

Chiara Lasco (student)

Silvia Martinelli (student)

Laura Bartoli (student)

Fiorella Scagnoli (student)

Clara Apicella (student)

Nicola Rizzo (CNR technician)


- Group leader, IBPM CNR

- Aggregate professor of Molecular Neurobiology, Università Sapienza

- Guido Berlucchi prize for Cancer Research (2009)

- CNR delegate at the ERA-Instruments project, European Commission (2008-11)

- Member of the High-level expert group for the European Science Foundation Forward Look on Systems Biology: a Grand Challenge for Europe (2003-2005)

- Professor of Oncology, Università Tor Vergata (2003-06)

- Visiting scientist, Dept. Molecular Biology, Princeton University, USA (2001)

- Visiting scientist, on various occasions, at Fred Hutchinson Cancer Center - Seattle, USA (1991-93)

- EMBO long-term fellow, Dept. de Biologie Moléculaire, Institut Pasteur, Paris, France (1977-8)

- CNR Researcher, Centro Acidi Nucleici (1975)

- Maître-assistant, Jeffrey Miller group, Dept. de Biologie Moléculaire, Université de Genève, CH

- Laurea in Physics, cum laude, Università degli Studi di Roma (1972)

- Summer fellow at CERN, Geneva, CH (1971)