• Istituto di Biologia e Patologia Molecolari


Tel :+39 0649912225
Fax :+390649912500
marcella.marchioni@cnr.it
MARCELLA MARCHIONI
Research Technician

National Research Council
Istitute of Molecular Biology and Pathology CNR
Department of Biology and Biotecnology - Charles Darwin - Sapienza University of Rome - p.le Aldo Moro, 5 - 00185 Roma
Sorci, M., et al METTL3 regulates WTAP protein homeostasis (2018) Cell Death and Disease, 9 (8).

Hughes, J.M., et al C/EBPa-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia(2015) Oncotarget, 6 (21), pp. 18534-18544.

Gioia, U., et. Al Mir-23a and mir-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1 (2014) RNA Biology, 11 (9), pp. 1105-1112.

Ballarino, M., et al Coupled RNA processing and transcription of intergenic primary microRNAs(2009) Molecular and Cellular Biology, 29 (20), pp. 5632-5638.

Rosa, A., et al The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (50), pp. 19849-19854.

Ballarino, M., et al Identification of positive and negative regulatory regions controlling expression of the Xenopus laevis βTrCP gen (2004) Gene, 336 (2), pp. 275-285.

Ballarino, M., et al The Xenopus laevis βTrCP gene: Genomic organization, alternative splicing, 5′ and 3′ region characterization and comparison of its structure with that of human βTrCP genes(2002) Biochimica et Biophysica Acta - Gene Structure and Expression, 1577 (1), pp. 81-92.

Lagna, G., et al Negative regulation of axis formation and Wnt signaling in Xenopus embryos by the F-box/WD40 protein βTrCP (1999) Mechanisms of Development, 80 (1), pp. 101-106.

Acknowledgments on Peer reviewed journals:

Pellegrini F, et al. A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment.
iScience. 2022 Dec 28;26(1):105891.

Carvelli A., et al. A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs.
EMBO J. 2022 Jul 4;41(13):e108918.

Rossi F., et al Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity. Mol Cell. 2022 Jan 6;82(1):75-89.e9.

Scalzitti S., et al Lnc-SMaRT Translational Regulation of Spire1, A New Player in Muscle Differentiation. J Mol Biol. 2022 Jan 30;434(2):167384.

Cipriano A., et al Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding RNA Lnc-Rewind in muscle stem cells. Elife. 2021 Jan 12;10:e54782.

D'Ambra E., et al Circ-Hdgfrp3 shuttles along neurites and is trapped in aggregates formed by ALS-associated mutant FUS. iScience. 2021 Nov 25;24(12):103504.

Rea J., et al Identification and Functional Characterization of Novel MYC-Regulated Long Noncoding RNAs in Group 3 Medulloblastoma. Cancers (Basel). 2021 Jul 30;13(15):3853.

Rossi F., et al CircVAMP3: A circRNA with a Role in Alveolar Rhabdomyosarcoma Cell Cycle Progression. Genes (Basel). 2021 Jun 28;12(7):985.

Desideri F., et al Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1.
Cell Rep. 2020 Dec 22;33(12):108548.

Rea J., et al HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade. Cell Death Dis. 2020 Jul 13;11(7):527.

Martone J., et al Trans-generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy. EMBO Mol Med. 2020 Aug 7;12(8):e12063.

Di Timoteo G., et al Modulation of circRNA Metabolism by m6A Modification.
Cell Rep. 2020 May 12;31(6):107641.

Martone J., et al SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA antagonizing the DHX36 helicase. EMBO Rep. 2020 Jun 4;21(6):e49942.

Rossi F., et al Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma.
Oncogene. 2019 May;38(20):3843-3854. doi: 10.1038/s41388-019-0699-4.

Ballarino M., et al Deficiency in the nuclear long noncoding RNA Charme causes myogenic defects and heart remodeling in mice. EMBO J. 2018 Sep 14;37(18):e99697.

Dimartino D., et al Cell Rep. 2018 Apr 17;23(3):733-740.
The Long Non-coding RNA lnc-31 Interacts with Rock1 mRNA and Mediates Its YB-1-Dependent Translation.

Biscarini S., et al Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALS.
Stem Cell Res. 2018 Mar;27:172-179.

Capauto D., et al A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons. Mol Neurobiol. 2018 Oct;55(10):7635-7651.

Laneve P., et al The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity. Oncotarget. 2017 May 9;8(19):31003-31015.

Errichelli L., et al FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Nat Commun. 2017 Mar 30;8:14741.

Legnini I., et al Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Mol Cell. 2017 Apr 6;66(1):22-37.e9.

Laneve P., et al Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration. Sci Rep. 2017 Jan 31;7:41559.

Gorgoni, B., et al Cloning, expression and functional role of XRPFI α and β subunits in xenopus laevis oocyte (1995) Biochemical and Biophysical Research Communications, 215 (3), pp. 1088-1095.

Marchioni, M., et al XrpFI, an amphibian transcription factor composed of multiple polypeptides immunologically related to the GA-binding protein α and β subunits, is differentially expressed during Xenopus laevis development
(1993) Molecular and Cellular Biology, 13 (10), pp. 6479-6489.
Partecipo alla linea di ricerca “Espressione Genica, Biologia dell'RNA, Epigenetica” dell’IBPM (www.ibpm.cnr), collaborando in particolare con la Dott.ssa Elisa Caffarelli e il Dott. Pietro Laneve  (IBPM), con la Prof.ssa Irene Bozzoni  (Prof. Ordinario di Biologia Molecolare, associato IBPM) e con il Prof. Alessandro Fatica (Professore ordinario di Biologia Molecolare c/o Dip di Biologia e Biotecnologie “C. Darwin”, Sapienza – Università di Roma) Le ricerche, riguardano lo sviluppo di modelli cellulari per lo studio di tumori del sistema nervoso centrale e per lo studio delle malattie degenerative

Marchioni Marcella (CTER IV livello),

Titolo di studio: Diploma superiore di Perito Chimico Industriale (60/60esimi)

Titoli professionali


Corso formazione per preposti, erogato dal Servizio Prevenzione e Protezione del CNR

Seminario di formazione in materia di radiazioni ionizzanti, presso Dip. di Biologia e Biotecnologie “C.Darwin” SAPIENZA Università di Roma - ISTITUTO DI BIOLOGIA E PATOLOGIA MOLECOLARI (IBPM.).

Operator training on BD FACSCanto II, presso BD Biosciences  - Buccinasco (MI) Italia

Steam Cell DifferentiationTraining Course Istituto di Genetica e Biofisica “Buzzati Traverso” CNR Napoli.

Formazione presso laboratori stanieri: Stage presso Rockefeller University –New York

La professionalità acquisita dalla sottoscritta, si è sviluppata prevalentemente nell’area della Biologia Cellulare. La partecipazione al lavoro di ricerca svolto presso il laboratorio “Acidi Nucleci” dell’Istituto di Biologia e Patologia Molecolari (IBPM) del CNR ha comportato l’apprendimento, la messa a punto e ottimizzazione di tecnologie di base, per evolversi successivamente con l’approfondimento di tecnologie più sofisticate. Tali competenze, oltre che essere sviluppate presso l’IBPM, sono state anche richieste, sotto forma di collaborazione, dal Dipartimento di Biologia e Biotecnologie “Charles Darwin” dell’Università La Sapienza di Roma.