• Istituto di Biologia e Patologia Molecolari

Tel :+390649910856
Fax :+39064440062

Istitute of Molecular Biology and Pathology - National Research Council
Department of Biochemical Sciences -A. Rossi Fanelli.
Sapienza University of Rome - Edificio di Chimica Biologica Terzo piano, stanza 301 P.le A. Moro 5 - 00185 Roma

Studies of oxidative stress-induced molecular changes in viral carcinogenesis and neurodegenerative diseases. Identification of protein expression profile alteration and oxidative post-translational modifications. Detection of selectively altered pathways, potential targets  for therapeutic approaches.


In details:

-Role of oxidative stress in neoplastic progression of cells infected with human papillomavirus (HPV): identification of oxidative damage targets and evaluation of cell stress response. Analysis on cells transformed with genome of high risk HPV and on cervical displastic and neoplastic  human tissues. Antioxidant compounds activity for cervical cancer prevention and therapy.

-Involvement of oxidative stress in Down Syndrome: identification of early molecular changes and correlation between specific protein oxidation and clinical outcomes.

- Implication of oxidative modifications of serum proteins in the occurrence of relapses in Multiple Sclerosis.

- Molecular mechanisms implied in development of Alzheimer Disease-like pathology in Down Syndrome: role of mTOR.


mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA. Free Radic Biol Med. 2018 ; 114:94-101

Redox control of viral carcinogenesis: The human papillomavirus paradigm. Foppoli C, De Marco F, Cini C, Perluigi M. Biochim Biophys Acta. 2015;1850:1622-32.

Role of oxidative stress in human papillomavirus-driven cervical carcinogenesis.
Foppoli C, Coccia R, Perluigi M. In: Victor R. Preedy (Ed), Cancer: Oxidative Stress and Dietary Antioxidants, Academic Press, 2014, Chapter 6, pp. 51-61.

Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis. Fiorini A, Koudriavtseva T, Bucaj E, Coccia R, Foppoli C, Giorgi A, Schininà ME, Di Domenico F, De Marco F, Perluigi M. PLoS One. 2013;8:e65184.

Oxidative stress in HPV-driven viral carcinogenesis: redox proteomics analysis of HPV-16 dysplastic and neoplastic tissues. De Marco F, Bucaj E, Foppoli C, Fiorini A, Blarzino C, Filipi K, Giorgi A, Schininà ME, Di Domenico F, Coccia R, Butterfield DA, Perluigi M. PLoS One. 2012;7:e34366.

Antioxidants in cervical cancer: chemopreventive and chemotherapeutic effects of polyphenols. Di Domenico F, Foppoli C, Coccia R, Perluigi M. Biochim Biophys Acta. Molecular Basis of Disease 2012; 1822:737-47.

Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid. Perluigi M, di Domenico F, Fiorini A, Cocciolo A, Giorgi A, Foppoli C, Butterfield DA, Giorlandino M, Giorlandino C, Schininà ME, Coccia R. Proteomics Clin Appl. 2011; 5:167-78.

Effects of UVB-induced oxidative stress on protein expression and specific protein oxidation in normal human epithelial keratinocytes: a proteomic approach. Perluigi M, Di Domenico F, Blarzino C, Foppoli C, Cini C, Giorgi A, Grillo C, De Marco F, Butterfield DA, Schininà ME, Coccia R. Proteome Sci. 2010;  18:8:13. 

Protective effect of ferulic acid ethyl ester against oxidative stress mediated by UVB irradiation in human epidermal melanocytes. Di Domenico F, Perluigi M, Foppoli C, Blarzino C, Coccia R, De Marco F, Butterfield DA, Cini C. Free Radic Res. 2009; 43:365-75.

Proteomics analysis of protein expression and specific protein oxidation in human papillomavirus transformed keratinocytes upon UVB irradiation. Perluigi M, Giorgi A, Blarzino C, De Marco F, Foppoli C, Di Domenico F, Butterfield DA, Schininà ME, Cini C, Coccia R. J Cell Mol Med. 2009; 13:1809-22.

UVB irradiation down-regulates HPV-16 RNA expression: implications for malignant progression of transformed cells. De Marco F, Perluigi M, Foppoli C, Blarzino C, Cini C, Coccia R, Venuti A. Virus Res. 2007; 130:249-59.

Biological response of human diploid keratinocytes to quinone-producing compounds: role of NAD(P)H:quinone oxidoreductase 1. Foppoli C, De Marco F, Blarzino C, Perluigi M, Cini C, Coccia R. Int J Biochem Cell Biol. 2005; 37:852-63.

Post doc

Antonella Tramutola and Andrea Arena, Sapienza University of Rome

With other Institutions:

Marzia Perluigi and Fabio Di Domenico, Department of Biochemical Sciences, Sapienza University of Rome

Federico De Marco, Regina Elena Institute for Cancer Research, Rome 

D Allan Butterfield, Lexington University, Kentucky (USA)


Place and date of birth: Marino (Rome), 15 July 1953

1976: Degree in Biological Sciences, University of Rome "La Sapienza", 110/100 magna cum laude

1978: Temporary Assistant in Molecular Biology, Faculty of Medicine, University of Rome "La Sapienza"

1979/80: Research award, II Biochemistry Chair, Faculty of Medicine, University of Rome "La Sapienza"

1985 to date: Researcher, Institute of Molecular Biology and Pathology, CNR, Rome


Main research lines:

- Studies on the metabolism of sulfur and selenium analogues of natural amino acids. Development of techniques for the synthesis of new compounds and evaluation of differences and analogies in their use for protein synthesis by bacterial and mammalian cells.

- Detection of new pathways of melanin synthesis. Identification of melanogenetic enzymatic systems and substrates. Physical-chemical characterization of synthetic melanins.

- Studies on the effects of oxidative stress induced by tetrahydroisoquinolines and detoxifying mechanism in normal and neoplastic epithelial cells (melanoma cells and human melanocytes and keratinocytes primary cultures). Evaluation of melanogenesis as protective mechanism.

- Studies on molecular mechanisms of preventive and protective effect of natural antioxidant compounds against oxidative damage of ultraviolet irradiation on skin.

- Investigation on the role of oxidative stress in neoplastic progression of HPV transformed cells. Proteomics and redox proteomics studies for identification of protein modifications. Evaluation of the involvement of specific proteins oxidation in cervical cancer development.

-Studies on Alzheimer-like neuropathology development in Down Syndrome: role of mTOR signalling alteration.